Michael Raghunath

Self-healing collodion baby: a dynamic phenotype explained by a particular transglutaminase-1 mutation.

Collagen metabolism is a novel target of the neuropeptide alpha-melanocyte-stimulating hormone.

SPINK5 and Netherton syndrome: novel mutations, demonstration of missing LEKTI, and differential expression of transglutaminases.

Generalized exfoliative erythroderma since birth. Netherton syndrome.

Serine proteinase inhibitors in the skin: role in homeostasis and disease.

Defensins HNP1 and HBD2 stimulation of wound-associated responses in human conjunctival fibroblasts.

In vitro enhancement of collagen matrix formation and crosslinking for applications in tissue engineering: a preliminary study.

Collagen matrix deposition is dramatically enhanced in vitro when crowded with charged macromolecules: the biological relevance of the excluded volume effect.

Emulating a crowded intracellular environment in vitro dramatically improves RT-PCR performance.

Electro-spinning of pure collagen nano-fibres - just an expensive way to make gelatin?

Pharmacologically induced angiogenesis in transgenic zebrafish.

Nanofiber patent landscape.

Early adhesive behavior of bone-marrow-derived mesenchymal stem cells on collagen electrospun fibers.

Understanding how the crowded interior of cells stabilizes DNA/DNA and DNA/RNA hybrids-in silico predictions and in vitro evidence.

Focus on collagen: in vitro systems to study fibrogenesis and antifibrosis state of the art.

Essential modification of the Sircol Collagen Assay for the accurate quantification of collagen content in complex protein solutions.

Characterization of amine donor and acceptor sites for tissue type transglutaminase using a sequence from the C-terminus of human fibrillin-1 and the N-terminus of osteonectin.

Applying macromolecular crowding to enhance extracellular matrix deposition and its remodeling in vitro for tissue engineering and cell-based therapies.

Matrix components and scaffolds for sustained islet function.

Effects of nanotopography on stem cell phenotypes.

Elastomeric electrospun scaffolds of poly(L-lactide-co-trimethylene carbonate) for myocardial tissue engineering.

Research highlights.

Atp8a1 deficiency is associated with phosphatidylserine externalization in hippocampus and delayed hippocampus-dependent learning.

Biomimetic surface modification of titanium surfaces for early cell capture by advanced electrospinning.

Macromolecular crowding directs extracellular matrix organization and mesenchymal stem cell behavior.

Human fibroblast matrices bio-assembled under macromolecular crowding support stable propagation of human embryonic stem cells.

Telomere length analysis of human mesenchymal stem cells by quantitative PCR.

Not all MSCs can act as pericytes: functional in vitro assays to distinguish pericytes from other mesenchymal stem cells in angiogenesis.

Cellular re- and de-programming by microenvironmental memory: why short TGF-β1 pulses can have long effects.

Macromolecular crowding amplifies adipogenesis of human bone marrow-derived mesenchymal stem cells by enhancing the pro-adipogenic microenvironment.

Complementary effects of ciclopirox olamine, a prolyl hydroxylase inhibitor and sphingosine 1-phosphate on fibroblasts and endothelial cells in driving capillary sprouting.

Macromolecular crowding meets tissue engineering by self-assembly: a paradigm shift in regenerative medicine.

Novel use for polyvinylpyrrolidone as a macromolecular crowder for enhanced extracellular matrix deposition and cell proliferation.

Mitochondrial routing of glucose and sucrose polymers after pinocytotic uptake: avenues for drug delivery.

Tuning the architecture of three-dimensional collagen hydrogels by physiological macromolecular crowding.

Making more matrix: enhancing the deposition of dermal-epidermal junction components in vitro and accelerating organotypic skin culture development, using macromolecular crowding.

Incorporation of a prolyl hydroxylase inhibitor into scaffolds: a strategy for stimulating vascularization.

Accelerated Development of Supramolecular Corneal Stromal-Like Assemblies from Corneal Fibroblasts in the Presence of Macromolecular Crowders.

Sourcing of an alternative pericyte-like cell type from peripheral blood in clinically relevant numbers for therapeutic angiogenic applications.

Differential effects of the extracellular microenvironment on human embryonic stem cell differentiation into keratinocytes and their subsequent replicative life span.

Synergistic rate boosting of collagen fibrillogenesis in heterogeneous mixtures of crowding agents.

Macromolecularly crowded in vitro microenvironments accelerate the production of extracellular matrix-rich supramolecular assemblies.

Establishing criteria for human mesenchymal stem cell potency.

Microcapsules engineered to support mesenchymal stem cell (MSC) survival and proliferation enable long-term retention of MSCs in infarcted myocardium.

Macromolecular crowding gives rise to microviscosity, anomalous diffusion and accelerated actin polymerization.

Simultaneous Delivery of Highly Diverse Bioactive Compounds from Blend Electrospun Fibers for Skin Wound Healing.

ECM microenvironment unlocks brown adipogenic potential of adult human bone marrow-derived MSCs.

Combination of ciclopirox olamine and sphingosine-1-phosphate as granulation enhancer in diabetic wounds.