Steven Jacobson

Viral Immunology Section, National Institute of Neurological Disorders and Stroke

Affiliated withNational Institute of Neurological Disorders and Stroke

Research Area

Neuroscience

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 32	2016

Other Publications

Article	Year
Correlation of human T-cell lymphotropic virus type 1 (HTLV-1) mRNA with proviral DNA load, virus-specific CD8(+) T cells, and disease severity in HTLV-1-associated myelopathy (HAM/TSP). Blood\| PubMed ID: 11756157	2002
Human T cell leukemia virus type I and neurologic disease: events in bone marrow, peripheral blood, and central nervous system during normal immune surveillance and neuroinflammation. Journal of cellular physiology\| PubMed ID: 11807819	2002
Selected cytotoxic T lymphocytes with high specificity for HTLV-I in cerebrospinal fluid from a HAM/TSP patient. Journal of neurovirology\| PubMed ID: 11847592	2002
Increased detection of serum HHV-6 DNA sequences during multiple sclerosis (MS) exacerbations and correlation with parameters of MS disease progression. Journal of neurovirology\| PubMed ID: 12053279	2002
Vascular endothelial growth factor is expressed in multiple sclerosis plaques and can induce inflammatory lesions in experimental allergic encephalomyelitis rats. Journal of neuropathology and experimental neurology\| PubMed ID: 12387457	2002
Immunopathogenesis of human T cell lymphotropic virus type I-associated neurologic disease. The Journal of infectious diseases\| PubMed ID: 12424696	2002
Pathological and virological assessment of acute HTLV-I-associated myelopathy complicated with encephalopathy and systemic inflammation. Journal of the neurological sciences\| PubMed ID: 12614936	2003
Detection of virus-specific T cells and CD8+ T-cell epitopes by acquisition of peptide-HLA-GFP complexes: analysis of T-cell phenotype and function in chronic viral infections. Nature medicine\| PubMed ID: 12652294	2003
Direct phenotypic analysis of human MHC class I antigen presentation: visualization, quantitation, and in situ detection of human viral epitopes using peptide-specific, MHC-restricted human ... Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 12682272	2003
High frequency of human herpesvirus 6 DNA in multiple sclerosis plaques isolated by laser microdissection. The Journal of infectious diseases\| PubMed ID: 12717618	2003
A novel multivalent human CTL peptide construct elicits robust cellular immune responses in HLA-A*0201 transgenic mice: implications for HTLV-1 vaccine design. Vaccine\| PubMed ID: 12798617	2003
Prediagnostic human T lymphotropic virus type I provirus loads were highest in Jamaican children who developed seborrheic dermatitis and severe anemia. The Journal of infectious diseases\| PubMed ID: 14702151	2004
Increased expression of human T lymphocyte virus type I (HTLV-I) Tax11-19 peptide-human histocompatibility leukocyte antigen A*201 complexes on CD4+ CD25+ T Cells detected by peptide-specifi... The Journal of experimental medicine\| PubMed ID: 15136590	2004
Use of a multi-virus array for the study of human viral and retroviral pathogens: gene expression studies and ChIP-chip analysis. Retrovirology\| PubMed ID: 15169557	2004
Quiescent phenotype of tumor-specific CD8+ T cells following immunization. Blood\| PubMed ID: 15187028	2004
Immunopathogensis of HTLV-I associated neurologic disease: molecular, histopathologic, and immunologic approaches. Frontiers in bioscience : a journal and virtual library\| PubMed ID: 15353305	2004
Protective efficacy of multiepitope human leukocyte antigen-A*0201 restricted cytotoxic T-lymphocyte peptide construct against challenge with human T-cell lymphotropic virus type 1 Tax recom... Journal of acquired immune deficiency syndromes (1999)\| PubMed ID: 15483462	2004
Focused cervical exploration for primary hyperparathyroidism without intraoperative parathyroid hormone monitoring or use of the gamma probe. World journal of surgery\| PubMed ID: 15490069	2004
Helminthic infection down-regulates type 1 immune responses in human T cell lymphotropic virus type 1 (HTLV-1) carriers and is more prevalent in HTLV-1 carriers than in patients with HTLV-1-... The Journal of infectious diseases\| PubMed ID: 15655786	2005
Parkinsonism in the course of HTLV-I-associated myelopathy. Movement disorders : official journal of the Movement Disorder Society\| PubMed ID: 15726580	2005
HPRT mutations, TCR gene rearrangements, and HTLV-1 integration sites define in vivo T-cell clonal lineages. Environmental and molecular mutagenesis\| PubMed ID: 15744741	2005
Interferon-beta1a therapy in human T-lymphotropic virus type I-associated neurologic disease. Annals of neurology\| PubMed ID: 15786444	2005
International Retrovirology Association brings together scientists and clinicians to bridge discoveries about human T-lymphotropic viruses from the laboratory to clinical trials. Retrovirology\| PubMed ID: 15796774	2005
Virus-induced dysfunction of CD4+CD25+ T cells in patients with HTLV-I-associated neuroimmunological disease. The Journal of clinical investigation\| PubMed ID: 15864353	2005
CD46 on glial cells can function as a receptor for viral glycoprotein-mediated cell-cell fusion. Glia\| PubMed ID: 15920733	2005
Human herpesvirus 6 and multiple sclerosis: potential mechanisms for virus-induced disease. Herpes : the journal of the IHMF\| PubMed ID: 16026638	2005
Differential tropism of human herpesvirus 6 (HHV-6) variants and induction of latency by HHV-6A in oligodendrocytes. Journal of neurovirology\| PubMed ID: 16162481	2005
Conventional magnetic resonance imaging features in patients with tropical spastic paraparesis. Journal of neurovirology\| PubMed ID: 16338746	2005
Human T lymphotropic virus types I and II western blot seroindeterminate status and its association with exposure to prototype HTLV-I. The Journal of infectious diseases\| PubMed ID: 16388491	2006
Differential HHV-6A gene expression in T cells and primary human astrocytes based on multi-virus array analysis. Glia\| PubMed ID: 16541415	2006
Immunostimulation by induced expression of NKG2D and its MIC ligands in HTLV-1-associated neurologic disease. Immunogenetics\| PubMed ID: 16568261	2006
HTLV-1 propels untransformed CD4 lymphocytes into the cell cycle while protecting CD8 cells from death. The Journal of clinical investigation\| PubMed ID: 16585963	2006
Chimeric peptide vaccine composed of B- and T-cell epitopes of human T-cell leukemia virus type 1 induces humoral and cellular immune responses and reduces the proviral load in immunized squ... The Journal of general virology\| PubMed ID: 16603536	2006
Foxp3 represses retroviral transcription by targeting both NF-kappaB and CREB pathways. PLoS pathogens\| PubMed ID: 16652169	2006
Reduced Foxp3 protein expression is associated with inflammatory disease during human t lymphotropic virus type 1 Infection. The Journal of infectious diseases\| PubMed ID: 16652285	2006
Natural history of viral markers in children infected with human T lymphotropic virus type I in Jamaica. The Journal of infectious diseases\| PubMed ID: 16897651	2006
Human T-cell leukemia virus type 1 (HTLV-1) and HTLV-2 use different receptor complexes to enter T cells. Journal of virology\| PubMed ID: 16912281	2006
Efficacy of antiviral compounds in human herpesvirus-6-infected glial cells. Journal of neurovirology\| PubMed ID: 16966219	2006
Natalizumab and immune cells. Archives of neurology\| PubMed ID: 17030649	2006
Complete replication cycle and acquisition of tegument in nucleus of human herpesvirus 6A in astrocytes and in T-cells. Journal of medical virology\| PubMed ID: 17063514	2006
GLUT1 is not the primary binding receptor but is associated with cell-to-cell transmission of human T-cell leukemia virus type 1. Journal of virology\| PubMed ID: 17108050	2007
Highlights from 5th International Conference on HHV-6 and -7. Herpes : the journal of the IHMF\| PubMed ID: 17147913	2006
Detection of active human herpesvirus-6 infection in the brain: correlation with polymerase chain reaction detection in cerebrospinal fluid. The Journal of infectious diseases\| PubMed ID: 17205485	2007
Detection of HHV-6B in post-mortem central nervous system tissue of a post-bone marrow transplant recipient: a multi-virus array analysis. Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology\| PubMed ID: 17276371	2006
Association of human herpesvirus-6B with mesial temporal lobe epilepsy. PLoS medicine\| PubMed ID: 17535102	2007
Purification of infectious human herpesvirus 6A virions and association of host cell proteins. Virology journal\| PubMed ID: 17949490	2007
Human herpesvirus 6 (HHV-6) induces dysregulation of glutamate uptake and transporter expression in astrocytes. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology\| PubMed ID: 18247129	2008
Dysregulation of TGF-beta signaling and regulatory and effector T-cell function in virus-induced neuroinflammatory disease. Blood\| PubMed ID: 18326816	2008
Reactivation of human herpesvirus-6 in natalizumab treated multiple sclerosis patients. PloS one\| PubMed ID: 18446218	2008
Retrovirally induced CTL degranulation mediated by IL-15 expression and infection of mononuclear phagocytes in patients with HTLV-I-associated neurologic disease. Blood\| PubMed ID: 18509087	2008
Surgical anatomy of the midcheek: facial layers, spaces, and the midcheek segments. Clinics in plastic surgery\| PubMed ID: 18558234	2008
Human herpes virus 6B: a possible role in epilepsy? Epilepsia\| PubMed ID: 18627418	2008
Treatment of HTLV-I-associated myelopathy/tropical spastic paraparesis: toward rational targeted therapy. Neurologic clinics\| PubMed ID: 18657726	2008
Anti-HTLV antibody profiling reveals an antibody signature for HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Retrovirology\| PubMed ID: 18937847	2008
Creating environment for cancer care. Health facilities management\| PubMed ID: 19172785	2008
Detection of human herpesvirus-6 in cerebrospinal fluid of patients with encephalitis. Annals of neurology\| PubMed ID: 19334059	2009
Regulatory T cells are reduced during anti-CD25 antibody treatment of multiple sclerosis. Archives of neurology\| PubMed ID: 19364932	2009
Detection of human herpesvirus-6 variants in pediatric brain tumors: association of viral antigen in low grade gliomas. Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology\| PubMed ID: 19505845	2009
Effect of (r)-9-[4-hydroxy-2-(hydroxymethyl)butyl]guanine (H2G) and AZT-lipid-PFA on human herpesvirus-6B infected cells. Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology\| PubMed ID: 19524486	2009
Abnormally high levels of virus-infected IFN-gamma+ CCR4+ CD4+ CD25+ T cells in a retrovirus-associated neuroinflammatory disorder. PloS one\| PubMed ID: 19654865	2009
Summary of the 6th International Conference on HHV-6 and -7. Herpes : the journal of the IHMF\| PubMed ID: 19856547	2008
Comparison of [(11)C]-(R)-PK 11195 and [(11)C]PBR28, two radioligands for translocator protein (18 kDa) in human and monkey: Implications for positron emission tomographic imaging of this in... NeuroImage\| PubMed ID: 19948230	2010
High expression of CD244 and SAP regulated CD8 T cell responses of patients with HTLV-I associated neurologic disease. PLoS pathogens\| PubMed ID: 19997502	2009
Multistability in a model for CTL response to HTLV-I infection and its implications to HAM/TSP development and prevention. Bulletin of mathematical biology\| PubMed ID: 20041353	2010
Preexisting infection with human T-cell lymphotropic virus type 2 neither exacerbates nor attenuates simian immunodeficiency virus SIVmac251 infection in macaques. Journal of virology\| PubMed ID: 20071587	2010
Neuroimmunity of HTLV-I Infection. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology\| PubMed ID: 20437106	2010
Viral infections of the central nervous system: pathogenesis to therapeutics. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology\| PubMed ID: 20658202	2010
Mechanism of neuroinflammation: enhanced cytotoxicity and IL-17 production via CD46 binding. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology\| PubMed ID: 20661655	2010
Review part 2: Human herpesvirus-6 in central nervous system diseases. Journal of medical virology\| PubMed ID: 20827763	2010
Translocator protein PET imaging for glial activation in multiple sclerosis. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology\| PubMed ID: 20872081	2011
TGF-β signaling is altered in the peripheral blood of subjects with multiple sclerosis. Journal of neuroimmunology\| PubMed ID: 21093933	2011
CP-690,550, a therapeutic agent, inhibits cytokine-mediated Jak3 activation and proliferation of T cells from patients with ATL and HAM/TSP. Blood\| PubMed ID: 21106989	2011
The NK cell as a new player in the pathogenesis of HTLV-I associated neurologic disease. Virulence\| PubMed ID: 21178408	2010
Inhibition of immune activation by a novel nuclear factor-kappa B inhibitor in HTLV-I-associated neurologic disease. Blood\| PubMed ID: 21212284	2011
Kinetics and intracellular compartmentalization of HTLV-1 gene expression: nuclear retention of HBZ mRNAs. Blood\| PubMed ID: 21398577	2011
Human herpesvirus-6 entry into the central nervous system through the olfactory pathway. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21825120	2011
In vivo quantification of T₂ anisotropy in white matter fibers in marmoset monkeys. NeuroImage\| PubMed ID: 21906687	2012
Etiologies of rash and fever illnesses in Campinas, Brazil. The Journal of infectious diseases\| PubMed ID: 21954258	2011
The prevalence and significance of HTLV-I/II seroindeterminate Western blot patterns. Viruses\| PubMed ID: 21994781	2011
Human T-lymphotropic virus type 1 (HTLV-1) and regulatory T cells in HTLV-1-associated neuroinflammatory disease. Viruses\| PubMed ID: 21994794	2011
Mediastinal silicone lymphadenopathy secondary to a ruptured breast implant. The breast journal\| PubMed ID: 21999800	2011
HTLV-I-associated myelopathy/tropical spastic paraparesis: semiautomatic quantification of spinal cord atrophy from 3-dimensional MR images. Journal of neuroimaging : official journal of the American Society of Neuroimaging\| PubMed ID: 22303896	2014
Quantitative differences in HTLV-I antibody responses: classification and relative risk assessment for asymptomatic carriers and ATL and HAM/TSP patients from Jamaica. Blood\| PubMed ID: 22318200	2012
Minocycline modulates antigen-specific CTL activity through inactivation of mononuclear phagocytes in patients with HTLV-I associated neurologic disease. Retrovirology\| PubMed ID: 22335964	2012
Translocator protein 18 kDa (TSPO) expression in multiple sclerosis patients. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology\| PubMed ID: 22956240	2013
Novel marmoset (Callithrix jacchus) model of human Herpesvirus 6A and 6B infections: immunologic, virologic and radiologic characterization. PLoS pathogens\| PubMed ID: 23382677	2013
Humoral immune response to HTLV-1 basic leucine zipper factor (HBZ) in HTLV-1-infected individuals. Retrovirology\| PubMed ID: 23405908	2013
Microvascular salvage of a thrombosed total ear replant. Microsurgery\| PubMed ID: 23640855	2013
Perivenular brain lesions in a primate multiple sclerosis model at 7-tesla magnetic resonance imaging. Multiple sclerosis (Houndmills, Basingstoke, England)\| PubMed ID: 23773983	2014
Impact and outcome of human acellular dermal matrix size for immediate and two-stage breast reconstruction. Plastic and reconstructive surgery\| PubMed ID: 23806904	2013
Positive feedback loop via astrocytes causes chronic inflammation in virus-associated myelopathy. Brain : a journal of neurology\| PubMed ID: 23892452	2013
Microbial biofilms and breast tissue expanders. BioMed research international\| PubMed ID: 23956974	2013
A systematic review of the use of Botulinum toxin type A with subpectoral breast implants. Journal of plastic, reconstructive & aesthetic surgery : JPRAS\| PubMed ID: 24094619	2014
Utility of HTLV proviral load quantification in diagnosis of HTLV-1-associated myelopathy requires international standardization. Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology\| PubMed ID: 24095029	2013
CSF CXCL10, CXCL9, and neopterin as candidate prognostic biomarkers for HTLV-1-associated myelopathy/tropical spastic paraparesis. PLoS neglected tropical diseases\| PubMed ID: 24130912	2013
Classification of HHV-6A and HHV-6B as distinct viruses. Archives of virology\| PubMed ID: 24193951	2014
Coinfection of human herpesviruses 6A (HHV-6A) and HHV-6B as demonstrated by novel digital droplet PCR assay. PloS one\| PubMed ID: 24663487	2014
In vivo immunogenicity of Tax(11-19) epitope in HLA-A2/DTR transgenic mice: implication for dendritic cell-based anti-HTLV-1 vaccine. Vaccine\| PubMed ID: 24739247	2014
Digital droplet PCR (ddPCR) for the precise quantification of human T-lymphotropic virus 1 proviral loads in peripheral blood and cerebrospinal fluid of HAM/TSP patients and identification o... Journal of neurovirology\| PubMed ID: 24781526	2014
Epigenetic modification of the FoxP3 TSDR in HAM/TSP decreases the functional suppression of Tregs. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology\| PubMed ID: 24845974	2014
Facelift complications related to median and peak blood pressure evaluation. Aesthetic plastic surgery\| PubMed ID: 24912427	2014
HTLV-1 induces a Th1-like state in CD4+CCR4+ T cells. The Journal of clinical investigation\| PubMed ID: 24960164	2014
Imaging Features of AlloDerm(®) Used in Postmastectomy Breast Reconstructions. Journal of clinical imaging science\| PubMed ID: 24987566	2014
Intraoperative angiography provides objective assessment of skin perfusion in complex knee reconstruction. Clinical orthopaedics and related research\| PubMed ID: 25005480	2015
In vivo imaging of spinal cord atrophy in neuroinflammatory diseases. Annals of neurology\| PubMed ID: 25042583	2014
The formation of inflammatory demyelinated lesions in cerebral white matter. Annals of neurology\| PubMed ID: 25088017	2014
Randomized trial of drain antisepsis after mastectomy and immediate prosthetic breast reconstruction. Annals of surgical oncology\| PubMed ID: 25096386	2014
Impact of reconstruction and reoperation on long-term patient-reported satisfaction after contralateral prophylactic mastectomy. Annals of surgical oncology\| PubMed ID: 25192678	2015
Inflammatory manifestations of HTLV-1 and their therapeutic options. Expert review of clinical immunology\| PubMed ID: 25340428	2014
Co-dependence of HTLV-1 p12 and p8 functions in virus persistence. PLoS pathogens\| PubMed ID: 25375128	2014
Evidence linking HHV-6 with multiple sclerosis: an update. Current opinion in virology\| PubMed ID: 25462444	2014
Red breast syndrome: a review of available literature. Aesthetic plastic surgery\| PubMed ID: 25608912	2015
Introducing the SKIN score: a validated scoring system to assess severity of mastectomy skin flap necrosis. Annals of surgical oncology\| PubMed ID: 25634782	2015
The Chitranjan Ranawat Award: Running Subcuticular Closure Enables the Most Robust Perfusion After TKA: A Randomized Clinical Trial. Clinical orthopaedics and related research\| PubMed ID: 25733009	2016
Human Herpesvirus 6 as a Viral Trigger in Mesial Temporal Lobe Epilepsy. The Journal of infectious diseases\| PubMed ID: 25840442	2015
Abstract 99: reducing unplanned reoperations for mastectomy skin flap necrosis - a multidisciplinary approach. Plastic and reconstructive surgery\| PubMed ID: 25942210	2014
Current strategies with 2-staged prosthetic breast reconstruction. Gland surgery\| PubMed ID: 26161305	2015
Targeting the binding interface on a shared receptor subunit of a cytokine family enables the inhibition of multiple member cytokines with selectable target spectrum. The Journal of biological chemistry\| PubMed ID: 26183780	2015
Expanded Indications and Improved Outcomes for Nipple-Sparing Mastectomy Over Time. Annals of surgical oncology\| PubMed ID: 26202567	2015
Common γ-chain blocking peptide reduces in vitro immune activation markers in HTLV-1-associated myelopathy/tropical spastic paraparesis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 26283355	2015
Comparative Study of Liposomal Bupivacaine Versus Paravertebral Block for Pain Control Following Mastectomy with Immediate Tissue Expander Reconstruction. Annals of surgical oncology\| PubMed ID: 26307232	2016
Is the SMAS Flap Facelift Safe? A Comparison of Complications Between the Sub-SMAS Approach Versus the Subcutaneous Approach With or Without SMAS Plication in Aesthetic Rhytidectomy at an Ac... Aesthetic plastic surgery\| PubMed ID: 26311561	2015
Custom fit 3D-printed brain holders for comparison of histology with MRI in marmosets. Journal of neuroscience methods\| PubMed ID: 26365332	2016
Revisiting an Old Place: Single Surgeon Experience on Post-Mastectomy Subcutaneous Implant Based Breast Reconstruction. Plastic and reconstructive surgery\| PubMed ID: 26397592	2015
Human T Cell Leukemia Virus Type 1 Infection of the Three Monocyte Subsets Contributes to Viral Burden in Humans. Journal of virology\| PubMed ID: 26608313	2015
Use of immediate breast reconstruction and choice for contralateral prophylactic mastectomy. Surgery\| PubMed ID: 26704783	2016
Tailoring through Technology: A Retrospective Review of a Single Surgeon's Experience with Implant-Based Breast Reconstruction before and after Implementation of Laser-Assisted Indocyanine G... The breast journal\| PubMed ID: 26899399	2016
Dual-Energy CT for Evaluation of Intra- and Extracapsular Silicone Implant Rupture. Case reports in radiology\| PubMed ID: 26942031	2016
Persistent 7-tesla phase rim predicts poor outcome in new multiple sclerosis patient lesions. The Journal of clinical investigation\| PubMed ID: 27270171	2016
Exosomes in Viral Disease. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics\| PubMed ID: 27324390	2016
Vaccinations for Neuroinfectious Disease: A Global Health Priority. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics\| PubMed ID: 27365085	2016
Editorial. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics\| PubMed ID: 27388287	2016
Cytokine Therapies in Neurological Disease. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics\| PubMed ID: 27388288	2016
Human herpesvirus multiplex ddPCR detection in brain tissue from low- and high-grade astrocytoma cases and controls. Infectious agents and cancer\| PubMed ID: 27462365	2016
Development of neurologic diseases in a patient with primate T lymphotropic virus type 1 (PTLV-1). Retrovirology\| PubMed ID: 27519553	2016
Intrathecal T-cell clonal expansions in patients with multiple sclerosis. Annals of clinical and translational neurology\| PubMed ID: 27547770	2016
Analyses of HTLV-1 sequences suggest interaction between ORF-I mutations and HAM/TSP outcome. Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases\| PubMed ID: 27553711	2016
Outcomes and feasibility of nipple-sparing mastectomy for node-positive breast cancer patients. American journal of surgery\| PubMed ID: 27692794	2016
Dynamic acquisition of HTLV-1 tax protein by mononuclear phagocytes: Role in neurologic disease. Journal of neuroimmunology\| PubMed ID: 27769524	2016
Reducing the global burden of HTLV-1 infection: An agenda for research and action. Antiviral research\| PubMed ID: 27840202	2016