W. Matthew Leevy

Synthetic hydraphile channels of appropriate length kill Escherichia coli.

Functional, synthetic organic chemical models of cellular ion channels.

Crown ethers: sensors for ions and molecular scaffolds for materials and biological models.

Synthetic ion channel activity documented by electrophysiological methods in living cells.

NMR and ion selective electrode studies of hydraphile channels correlate with biological activity in E. coli and B. subtilis.

The influence of aromatic residues in hydraphile spacer units: assay by ion selective electrode methods and in bacteria.

Correlation of bilayer membrane cation transport and biological activity in alkyl-substituted lariat ethers.

Structure-activity relationships, kinetics, selectivity, and mechanistic studies of synthetic hydraphile channels in bacterial and mammalian cells.

A synthetic, chloride-selective channel that alters chloride transport in epithelial cells.

Spectral unmixing of multicolored bioluminescence emitted from heterogeneous biological sources.

Selective recognition of bacterial membranes by zinc(II)-coordination complexes.

Optical imaging of bacterial infection in living mice using a fluorescent near-infrared molecular probe.

Squaraine rotaxanes: superior substitutes for Cy-5 in molecular probes for near-infrared fluorescence cell imaging.

Zinc(II) coordination complexes as membrane-active fluorescent probes and antibiotics.

Noninvasive optical imaging of staphylococcus aureus bacterial infection in living mice using a Bis-dipicolylamine-Zinc(II) affinity group conjugated to a near-infrared fluorophore.

Quantum dot probes for bacteria distinguish Escherichia coli mutants and permit in vivo imaging.

The Influence of Varied Amide Bond Positions on Hydraphile Ion Channel Activity.

Optical imaging of mammary and prostate tumors in living animals using a synthetic near infrared zinc(II)-dipicolylamine probe for anionic cell surfaces.

Recent Advances in Synthetic Membrane Transporters.

Optical Imaging of Bacterial Infection Models.

Optical imaging of bacterial infection in living mice using deep-red fluorescent squaraine rotaxane probes.

Storable, thermally activated, near-infrared chemiluminescent dyes and dye-stained microparticles for optical imaging.

In vivo optical imaging of acute cell death using a near-infrared fluorescent zinc-dipicolylamine probe.

In vivo cell death mediated by synthetic ion channels.

Imaging and analysis of Pseudomonas aeruginosa swarming and rhamnolipid production.

A 24-Hour Temporal Profile of In Vivo Brain and Heart PET Imaging Reveals a Nocturnal Peak in Brain F-Fluorodeoxyglucose Uptake.