Department of Anatomy and Embryology
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SOST expression is restricted to the great arteries during embryonic and neonatal cardiovascular development.
Developmental dynamics : an official publication of the American Association of Anatomists Feb, 2007 | Pubmed ID: 17195180
Prospects for pluripotent stem cell-derived cardiomyocytes in cardiac cell therapy and as disease models.
Journal of cellular biochemistry Jul, 2009 | Pubmed ID: 19449339
Extracellular matrix formation after transplantation of human embryonic stem cell-derived cardiomyocytes.
Cellular and molecular life sciences : CMLS Jan, 2010 | Pubmed ID: 19844658
Challenges in using stem cells for cardiac repair.
Science translational medicine Apr, 2010 | Pubmed ID: 20393186
Cardiomyocyte differentiation of pluripotent stem cells and their use as cardiac disease models.
The Biochemical journal Feb, 2011 | Pubmed ID: 21269276
Pluripotent stem cell models of cardiac disease and their implication for drug discovery and development.
Trends in molecular medicine Sep, 2011 | Pubmed ID: 21703926
Shedding new light on the mechanism underlying stem cell therapy for the heart.
Molecular therapy : the journal of the American Society of Gene Therapy Jul, 2011 | Pubmed ID: 21720378
Human embryonic and fetal mesenchymal stem cells differentiate toward three different cardiac lineages in contrast to their adult counterparts.
PloS one , 2011 | Pubmed ID: 21931658
New perspectives on regeneration of the heart.
Circulation research Sep, 2011 | Pubmed ID: 21960722
Smooth muscle diversity from human pluripotent cells.
Nature biotechnology Feb, 2012 | Pubmed ID: 22318032
Cardiomyocytes derived from pluripotent stem cells recapitulate electrophysiological characteristics of an overlap syndrome of cardiac sodium channel disease.
Circulation Jun, 2012 | Pubmed ID: 22647976
Induced pluripotent stem cells: the new patient?
Nature reviews. Molecular cell biology Nov, 2012 | Pubmed ID: 23034453
Model systems for cardiovascular regenerative biology.
Cold Spring Harbor perspectives in medicine Apr, 2013 | Pubmed ID: 23545574
Is heart regeneration on the right track?
Nature medicine Apr, 2013 | Pubmed ID: 23558629
Conversion of mature human β-cells into glucagon-producing α-cells.
Diabetes Jul, 2013 | Pubmed ID: 23569174
Generation of induced pluripotent stem cells from human foetal fibroblasts using the Sleeping Beauty transposon gene delivery system.
Differentiation; research in biological diversity Jul-Sep, 2013 | Pubmed ID: 23933400
Direct cardiomyocyte reprogramming: a new direction for cardiovascular regenerative medicine.
Cold Spring Harbor perspectives in medicine Sep, 2013 | Pubmed ID: 24003244
Functionality of endothelial cells and pericytes from human pluripotent stem cells demonstrated in cultured vascular plexus and zebrafish xenografts.
Arteriosclerosis, thrombosis, and vascular biology Jan, 2014 | Pubmed ID: 24158517
Isogenic human pluripotent stem cell pairs reveal the role of a KCNH2 mutation in long-QT syndrome.
The EMBO journal Dec, 2013 | Pubmed ID: 24213244
PGC-1α and reactive oxygen species regulate human embryonic stem cell-derived cardiomyocyte function.
Stem cell reports , 2013 | Pubmed ID: 24371810
Strategies for rapidly mapping proviral integration sites and assessing cardiogenic potential of nascent human induced pluripotent stem cell clones.
Experimental cell research Oct, 2014 | Pubmed ID: 24836851
Generation, expansion and functional analysis of endothelial cells and pericytes derived from human pluripotent stem cells.
Nature protocols , 2014 | Pubmed ID: 24874816
SIRPA, VCAM1 and CD34 identify discrete lineages during early human cardiovascular development.
Stem cell research Jul, 2014 | Pubmed ID: 24968096
Serum supplemented culture medium masks hypertrophic phenotypes in human pluripotent stem cell derived cardiomyocytes.
Journal of cellular and molecular medicine Aug, 2014 | Pubmed ID: 24981391
Cell replacement therapies: is it time to reprogram?
Human gene therapy Oct, 2014 | Pubmed ID: 25141889
Assessment of functional competence of endothelial cells from human pluripotent stem cells in zebrafish embryos.
Methods in molecular biology (Clifton, N.J.) , 2014 | Pubmed ID: 25173378
A case for crowd sourcing in stem cell research.
Stem cells translational medicine Nov, 2014 | Pubmed ID: 25232185
Recessive cardiac phenotypes in induced pluripotent stem cell models of Jervell and Lange-Nielsen syndrome: disease mechanisms and pharmacological rescue.
Proceedings of the National Academy of Sciences of the United States of America Dec, 2014 | Pubmed ID: 25453094
Pluripotent stem cell derived cardiovascular progenitors--a developmental perspective.
Developmental biology Apr, 2015 | Pubmed ID: 25624264
Differentiation of Human Pluripotent Stem Cells to Cardiomyocytes Under Defined Conditions.
Methods in molecular biology (Clifton, N.J.) , 2016 | Pubmed ID: 25626427
Atrial-like cardiomyocytes from human pluripotent stem cells are a robust preclinical model for assessing atrial-selective pharmacology.
EMBO molecular medicine Apr, 2015 | Pubmed ID: 25700171
Functional maturation of human pluripotent stem cell derived cardiomyocytes in vitro--correlation between contraction force and electrophysiology.
Biomaterials May, 2015 | Pubmed ID: 25771005
Lymphangiogenesis and angiogenesis during human fetal pancreas development.
Vascular cell , 2014 | Pubmed ID: 25785186
Reply to Christ et al.: LQT1 and JLNS phenotypes in hiPSC-derived cardiomyocytes are due to KCNQ1 mutations.
Proceedings of the National Academy of Sciences of the United States of America Apr, 2015 | Pubmed ID: 25795241
What Endothelial Cells from Patient iPSCs Can Tell Us about Aortic Valve Disease.
Cell stem cell May, 2015 | Pubmed ID: 25957898
The composition and differentiation potential of the duodenal intraepithelial innate lymphocyte compartment is altered in coeliac disease.
Gut Aug, 2016 | Pubmed ID: 25966995
KeyGenes, a Tool to Probe Tissue Differentiation Using a Human Fetal Transcriptional Atlas.
Stem cell reports Jun, 2015 | Pubmed ID: 26028532
Expansion and patterning of cardiovascular progenitors derived from human pluripotent stem cells.
Nature biotechnology Sep, 2015 | Pubmed ID: 26192318
Transcriptome of human foetal heart compared with cardiomyocytes from pluripotent stem cells.
Development (Cambridge, England) Sep, 2015 | Pubmed ID: 26209647
Altered calcium handling and increased contraction force in human embryonic stem cell derived cardiomyocytes following short term dexamethasone exposure.
Biochemical and biophysical research communications Nov, 2015 | Pubmed ID: 26456652
Contractile Defect Caused by Mutation in MYBPC3 Revealed under Conditions Optimized for Human PSC-Cardiomyocyte Function.
Cell reports Oct, 2015 | Pubmed ID: 26489474
Induced Pluripotent Stem Cells to Model Human Fibrodysplasia Ossificans Progressiva.
Stem cell reports Dec, 2015 | Pubmed ID: 26626181
Advantages of the avian model for human ovarian cancer.
Molecular and clinical oncology Nov, 2015 | Pubmed ID: 26807219
Interaction Between ALK1 Signaling and Connexin40 in the Development of Arteriovenous Malformations.
Arteriosclerosis, thrombosis, and vascular biology Apr, 2016 | Pubmed ID: 26821948
The avian embryo to study development of the cardiac conduction system.
Differentiation; research in biological diversity Apr-Jun, 2016 | Pubmed ID: 26856662
Complex Tissue and Disease Modeling using hiPSCs.
Cell stem cell Mar, 2016 | Pubmed ID: 26942851
Position Paper of the European Society of Cardiology Working Group Cellular Biology of the Heart: cell-based therapies for myocardial repair and regeneration in ischemic heart disease and heart failure.
European heart journal Apr, 2016 | Pubmed ID: 27055812
Stem cells: The cancer's gone, but did chemotherapy damage your heart?
Nature reviews. Cardiology Jul, 2016 | Pubmed ID: 27226155
Concise Review: Measuring Physiological Responses of Human Pluripotent Stem Cell Derived Cardiomyocytes to Drugs and Disease.
Stem cells (Dayton, Ohio) Aug, 2016 | Pubmed ID: 27250776
Inherited heart disease - what can we expect from the second decade of human iPS cell research?
FEBS letters Aug, 2016 | Pubmed ID: 27391414
A new hERG allosteric modulator rescues genetic and drug-induced long-QT syndrome phenotypes in cardiomyocytes from isogenic pairs of patient induced pluripotent stem cells.
EMBO molecular medicine 09, 2016 | Pubmed ID: 27470144
Integrating cardiomyocytes from human pluripotent stem cells in safety pharmacology: has the time come?
British journal of pharmacology Sep, 2016 | Pubmed ID: 27641943
Readthrough-Promoting Drugs Gentamicin and PTC124 Fail to Rescue Nav1.5 Function of Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes Carrying Nonsense Mutations in the Sodium Channel Gene SCN5A.
Circulation. Arrhythmia and electrophysiology Nov, 2016 | Pubmed ID: 27784737
Small molecule absorption by PDMS in the context of drug response bioassays.
Biochemical and biophysical research communications Jan, 2017 | Pubmed ID: 27856254
TECRL, a new life-threatening inherited arrhythmia gene associated with overlapping clinical features of both LQTS and CPVT.
EMBO molecular medicine 12, 2016 | Pubmed ID: 27861123
Interpretation of field potentials measured on a multi electrode array in pharmacological toxicity screening on primary and human pluripotent stem cell-derived cardiomyocytes.
Biochemical and biophysical research communications 03, 2018 | Pubmed ID: 28153730
Subtype-specific promoter-driven action potential imaging for precise disease modelling and drug testing in hiPSC-derived cardiomyocytes.
European heart journal Jan, 2017 | Pubmed ID: 28182242
Three-dimensional cardiac microtissues composed of cardiomyocytes and endothelial cells co-differentiated from human pluripotent stem cells.
Development (Cambridge, England) Mar, 2017 | Pubmed ID: 28279973
Differentiation-Defective Human Induced Pluripotent Stem Cells Reveal Strengths and Limitations of the Teratoma Assay and In Vitro Pluripotency Assays.
Stem cell reports 05, 2017 | Pubmed ID: 28494940
FANTOM5 CAGE profiles of human and mouse samples.
Scientific data 08, 2017 | Pubmed ID: 28850106
Human pluripotent stem cell models of cardiac disease: from mechanisms to therapies.
Disease models & mechanisms 09, 2017 | Pubmed ID: 28883014
DNA methylation and transcriptional trajectories during human development and reprogramming of isogenic pluripotent stem cells.
Nature communications 10, 2017 | Pubmed ID: 29030611
Co-Differentiation of Human Pluripotent Stem Cells-Derived Cardiomyocytes and Endothelial Cells from Cardiac Mesoderm Provides a Three-Dimensional Model of Cardiac Microtissue.
Current protocols in human genetics 10, 2017 | Pubmed ID: 29044469
Executive summary of the 12th HHT international scientific conference.
Angiogenesis Feb, 2018 | Pubmed ID: 29147802
A COUP-TFII Human Embryonic Stem Cell Reporter Line to Identify and Select Atrial Cardiomyocytes.
Stem cell reports 12, 2017 | Pubmed ID: 29173897
Human Pluripotent Stem Cell Differentiation into Functional Epicardial Progenitor Cells.
Stem cell reports 12, 2017 | Pubmed ID: 29173898
MUSCLEMOTION: A Versatile Open Software Tool to Quantify Cardiomyocyte and Cardiac Muscle Contraction In Vitro and In Vivo.
Circulation research Feb, 2018 | Pubmed ID: 29282212
Squaramide-Based Supramolecular Materials for Three-Dimensional Cell Culture of Human Induced Pluripotent Stem Cells and Their Derivatives.
Biomacromolecules Apr, 2018 | Pubmed ID: 29528623
NKX2-5 regulates human cardiomyogenesis via a HEY2 dependent transcriptional network.
Nature communications 04, 2018 | Pubmed ID: 29636455
Inflammatory Responses and Barrier Function of Endothelial Cells Derived from Human Induced Pluripotent Stem Cells.
Stem cell reports May, 2018 | Pubmed ID: 29657098
Advanced in vitro models of vascular biology: Human induced pluripotent stem cells and organ-on-chip technology.
Advanced drug delivery reviews Jun, 2018 | Pubmed ID: 29944904
Quantification of Muscle Contraction In Vitro and In Vivo Using MUSCLEMOTION Software: From Stem Cell-Derived Cardiomyocytes to Zebrafish and Human Hearts.
Current protocols in human genetics Oct, 2018 | Pubmed ID: 30253059
Cytostretch, an Organ-on-Chip Platform.
Micromachines Jul, 2016 | Pubmed ID: 30404293
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