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CNRS,
UMR-5203,
CNRS, UMR-5203
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Closure of the Venus flytrap module of mGlu8 receptor and the activation process: Insights from mutations converting antagonists into agonists.
Proceedings of the National Academy of Sciences of the United States of America Aug, 2002 | Pubmed ID: 12151600
Confinement but not microgravity alters NMDA NR1 receptor expression in rat inner ear ganglia.
Neuroreport May, 2003 | Pubmed ID: 12858054
Heptahelical domain of metabotropic glutamate receptor 5 behaves like rhodopsin-like receptors.
Proceedings of the National Academy of Sciences of the United States of America Jan, 2004 | Pubmed ID: 14691258
Palmitoylation of the 5-hydroxytryptamine4a receptor regulates receptor phosphorylation, desensitization, and beta-arrestin-mediated endocytosis.
Molecular pharmacology May, 2005 | Pubmed ID: 15689570
Uncoupling and endocytosis of 5-hydroxytryptamine 4 receptors. Distinct molecular events with different GRK2 requirements.
The Journal of biological chemistry Jul, 2005 | Pubmed ID: 15919661
5-hydroxytryptamine 4 receptor activation of the extracellular signal-regulated kinase pathway depends on Src activation but not on G protein or beta-arrestin signaling.
Molecular biology of the cell Jun, 2007 | Pubmed ID: 17377064
Synthesis and biological evaluation of 1-amino-2-phosphonomethylcyclopropanecarboxylic acids, new group III metabotropic glutamate receptor agonists.
Journal of medicinal chemistry Jul, 2007 | Pubmed ID: 17602546
Conformational toggle switches implicated in basal constitutive and agonist-induced activated states of 5-hydroxytryptamine-4 receptors.
Molecular pharmacology Apr, 2009 | Pubmed ID: 19168624
Beta-arrestin1 phosphorylation by GRK5 regulates G protein-independent 5-HT4 receptor signalling.
The EMBO journal Sep, 2009 | Pubmed ID: 19661922
G protein activation by serotonin type 4 receptor dimers: evidence that turning on two protomers is more efficient.
The Journal of biological chemistry Mar, 2011 | Pubmed ID: 21247891
Gα(olf) mutation allows parsing the role of cAMP-dependent and extracellular signal-regulated kinase-dependent signaling in L-3,4-dihydroxyphenylalanine-induced dyskinesia.
The Journal of neuroscience : the official journal of the Society for Neuroscience Apr, 2012 | Pubmed ID: 22539851
5-HT(6) receptor recruitment of mTOR as a mechanism for perturbed cognition in schizophrenia.
EMBO molecular medicine Oct, 2012 | Pubmed ID: 23027611
Pharmacological profile of engineered 5-HT₄ receptors and identification of 5-HT₄ receptor-biased ligands.
Brain research May, 2013 | Pubmed ID: 23148949
5-HT4 receptors constitutively promote the non-amyloidogenic pathway of APP cleavage and interact with ADAM10.
ACS chemical neuroscience Jan, 2013 | Pubmed ID: 23336052
Serotonin type 4 receptor dimers.
Methods in cell biology , 2013 | Pubmed ID: 24143975
Early administration of RS 67333, a specific 5-HT4 receptor agonist, prevents amyloidogenesis and behavioral deficits in the 5XFAD mouse model of Alzheimer's disease.
Frontiers in aging neuroscience , 2013 | Pubmed ID: 24399967
Design of donecopride, a dual serotonin subtype 4 receptor agonist/acetylcholinesterase inhibitor with potential interest for Alzheimer's disease treatment.
Proceedings of the National Academy of Sciences of the United States of America Aug, 2014 | Pubmed ID: 25157130
Institut de Génomique Fonctionnelle, Montpellier
U661, Montpellier
Universités de Montpellier
Florence Gaven1,2,3,
Philippe Marin1,2,3,
Sylvie Claeysen1,2,3
1CNRS, UMR-5203, Institut de Génomique Fonctionnelle, Montpellier,
2Inserm, U661, Montpellier,
3, Universités de Montpellier
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