Department of Developmental Immunology
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Natural killer T cell ligand alpha-galactosylceramide enhances protective immunity induced by malaria vaccines.
The Journal of experimental medicine Mar, 2002 | Pubmed ID: 11877484
Colitis-related public T cells are selected in the colonic lamina propria of IL-10-deficient mice.
Clinical immunology (Orlando, Fla.) Mar, 2002 | Pubmed ID: 11890710
Precursors of functional MHC class I- or class II-restricted CD8alphaalpha(+) T cells are positively selected in the thymus by agonist self-peptides.
Immunity Mar, 2002 | Pubmed ID: 11911821
Regulation of mucosal immune responses by recombinant interleukin 10 produced by intestinal epithelial cells in mice.
Gastroenterology Jun, 2002 | Pubmed ID: 12055591
The V alpha 14 NKT cell TCR exhibits high-affinity binding to a glycolipid/CD1d complex.
Journal of immunology (Baltimore, Md. : 1950) Aug, 2002 | Pubmed ID: 12133957
Prolonged IFN-gamma-producing NKT response induced with alpha-galactosylceramide-loaded DCs.
Nature immunology Sep, 2002 | Pubmed ID: 12154358
The unconventional lifestyle of NKT cells.
Nature reviews. Immunology Aug, 2002 | Pubmed ID: 12154375
CD1 tetramers: a powerful tool for the analysis of glycolipid-reactive T cells.
Journal of immunological methods Oct, 2002 | Pubmed ID: 12213347
Homeostasis of V alpha 14i NKT cells.
Nature immunology Oct, 2002 | Pubmed ID: 12244311
Quantitation and phenotypic analysis of natural killer T cells in primary biliary cirrhosis using a human CD1d tetramer.
Gastroenterology Oct, 2002 | Pubmed ID: 12360465
Peptide-independent folding and CD8 alpha alpha binding by the nonclassical class I molecule, thymic leukemia antigen.
Journal of immunology (Baltimore, Md. : 1950) Nov, 2002 | Pubmed ID: 12421950
Disruption of T helper 2-immune responses in Epstein-Barr virus-induced gene 3-deficient mice.
Proceedings of the National Academy of Sciences of the United States of America Dec, 2002 | Pubmed ID: 12482940
Human invariant V alpha 24-J alpha Q TCR supports the development of CD1d-dependent NK1.1+ and NK1.1- T cells in transgenic mice.
Journal of immunology (Baltimore, Md. : 1950) Mar, 2003 | Pubmed ID: 12594262
The crystal structure of a TL/CD8alphaalpha complex at 2.1 A resolution: implications for modulation of T cell activation and memory.
Immunity Feb, 2003 | Pubmed ID: 12594948
Essential role of NKT cells producing IL-4 and IL-13 in the development of allergen-induced airway hyperreactivity.
Nature medicine May, 2003 | Pubmed ID: 12669034
Surprisingly minor influence of TRAV11 (Valpha14) polymorphism on NK T-receptor mCD1/alpha-galactosylceramide binding kinetics.
Immunogenetics Mar, 2003 | Pubmed ID: 12671739
CD1d-expressing dendritic cells but not thymic epithelial cells can mediate negative selection of NKT cells.
The Journal of experimental medicine Apr, 2003 | Pubmed ID: 12682110
Schistosoma mansoni antigens modulate the activity of the innate immune response and prevent onset of type 1 diabetes.
European journal of immunology May, 2003 | Pubmed ID: 12731071
NIK-dependent RelB activation defines a unique signaling pathway for the development of V alpha 14i NKT cells.
The Journal of experimental medicine Jun, 2003 | Pubmed ID: 12810685
Intrathymic NKT cell development is blocked by the presence of alpha-galactosylceramide.
European journal of immunology Jul, 2003 | Pubmed ID: 12811841
Mouse V alpha 14i natural killer T cells are resistant to cytokine polarization in vivo.
Proceedings of the National Academy of Sciences of the United States of America Jul, 2003 | Pubmed ID: 12829795
Cross-presentation of disialoganglioside GD3 to natural killer T cells.
The Journal of experimental medicine Jul, 2003 | Pubmed ID: 12847141
Cutting edge: invariant V alpha 14 NKT cells are required for allergen-induced airway inflammation and hyperreactivity in an experimental asthma model.
Journal of immunology (Baltimore, Md. : 1950) Aug, 2003 | Pubmed ID: 12902459
An anti-inflammatory role for V alpha 14 NK T cells in Mycobacterium bovis bacillus Calmette-Guérin-infected mice.
Journal of immunology (Baltimore, Md. : 1950) Aug, 2003 | Pubmed ID: 12902499
CD4+ CD25+ T cells responding to serologically defined autoantigens suppress antitumor immune responses.
Proceedings of the National Academy of Sciences of the United States of America Sep, 2003 | Pubmed ID: 12947044
Glycolipid antigen drives rapid expansion and sustained cytokine production by NK T cells.
Journal of immunology (Baltimore, Md. : 1950) Oct, 2003 | Pubmed ID: 14530322
Constitutive cytokine mRNAs mark natural killer (NK) and NK T cells poised for rapid effector function.
The Journal of experimental medicine Oct, 2003 | Pubmed ID: 14530376
The adaptor protein AP-3 is required for CD1d-mediated antigen presentation of glycosphingolipids and development of Valpha14i NKT cells.
The Journal of experimental medicine Oct, 2003 | Pubmed ID: 14557411
Activation of natural killer T cells in NZB/W mice induces Th1-type immune responses exacerbating lupus.
The Journal of clinical investigation Oct, 2003 | Pubmed ID: 14561706
Natural killer T cells: natural or unnatural regulators of autoimmunity?
Current opinion in immunology Dec, 2003 | Pubmed ID: 14630203
MHC-dependent and -independent modulation of endogenous Ly49 receptors on NK1.1+ T lymphocytes directed by T-cell receptor type.
Immunology Nov, 2003 | Pubmed ID: 14632658
Cutaneous immunization rapidly activates liver invariant Valpha14 NKT cells stimulating B-1 B cells to initiate T cell recruitment for elicitation of contact sensitivity.
The Journal of experimental medicine Dec, 2003 | Pubmed ID: 14676294
Presenting fats with SAPs.
Nature immunology Feb, 2004 | Pubmed ID: 14749781
Surface receptors identify mouse NK1.1+ T cell subsets distinguished by function and T cell receptor type.
European journal of immunology Jan, 2004 | Pubmed ID: 14971030
Expansion of human Valpha24+ NKT cells by repeated stimulation with KRN7000.
Journal of immunological methods Feb, 2004 | Pubmed ID: 14980434
NKT cells: what's in a name?
Nature reviews. Immunology Mar, 2004 | Pubmed ID: 15039760
CD1d1 displayed on cell size beads identifies and enriches an NK cell population negatively regulated by CD1d1.
Journal of immunology (Baltimore, Md. : 1950) May, 2004 | Pubmed ID: 15100269
Systemic NKT cell deficiency in NOD mice is not detected in peripheral blood: implications for human studies.
Immunology and cell biology Jun, 2004 | Pubmed ID: 15186254
The Third Way: Progress on pathways of antigen processing and presentation by CD1.
Immunology and cell biology Jun, 2004 | Pubmed ID: 15186261
The T cell antigen receptor expressed by Valpha14i NKT cells has a unique mode of glycosphingolipid antigen recognition.
Proceedings of the National Academy of Sciences of the United States of America Aug, 2004 | Pubmed ID: 15304644
Salmonella typhimurium infection halts development of type 1 diabetes in NOD mice.
European journal of immunology Nov, 2004 | Pubmed ID: 15376194
Going both ways: immune regulation via CD1d-dependent NKT cells.
The Journal of clinical investigation Nov, 2004 | Pubmed ID: 15545985
The role of innate immunity in autoimmunity.
The Journal of experimental medicine Dec, 2004 | Pubmed ID: 15611284
ICOS costimulates invariant NKT cell activation.
Biochemical and biophysical research communications Feb, 2005 | Pubmed ID: 15629449
Bacterial glycolipids and analogs as antigens for CD1d-restricted NKT cells.
Proceedings of the National Academy of Sciences of the United States of America Feb, 2005 | Pubmed ID: 15665086
Mesenteric B cells centrally inhibit CD4+ T cell colitis through interaction with regulatory T cell subsets.
Proceedings of the National Academy of Sciences of the United States of America Feb, 2005 | Pubmed ID: 15684084
IFN-gamma-mediated negative feedback regulation of NKT-cell function by CD94/NKG2.
Blood Jul, 2005 | Pubmed ID: 15746081
The mouse CD1d cytoplasmic tail mediates CD1d trafficking and antigen presentation by adaptor protein 3-dependent and -independent mechanisms.
Journal of immunology (Baltimore, Md. : 1950) Mar, 2005 | Pubmed ID: 15749847
Molecular basis for the high affinity interaction between the thymic leukemia antigen and the CD8alphaalpha molecule.
Journal of immunology (Baltimore, Md. : 1950) Mar, 2005 | Pubmed ID: 15749886
Toward an understanding of NKT cell biology: progress and paradoxes.
Annual review of immunology , 2005 | Pubmed ID: 15771592
Cutting edge: IFN-gamma signaling to macrophages is required for optimal Valpha14i NK T/NK cell cross-talk.
Journal of immunology (Baltimore, Md. : 1950) Apr, 2005 | Pubmed ID: 15778340
Recognition of bacterial glycosphingolipids by natural killer T cells.
Nature Mar, 2005 | Pubmed ID: 15791257
Intravascular immune surveillance by CXCR6+ NKT cells patrolling liver sinusoids.
PLoS biology Apr, 2005 | Pubmed ID: 15799695
CD1 and MHC II find different means to the same end.
Trends in immunology May, 2005 | Pubmed ID: 15866242
A murine model of NKT cell-mediated liver injury induced by alpha-galactosylceramide/d-galactosamine.
Virchows Archiv : an international journal of pathology Jun, 2005 | Pubmed ID: 15906084
Regulation of immunity by self-reactive T cells.
Nature Jun, 2005 | Pubmed ID: 15931212
Mucosal T lymphocytes--peacekeepers and warriors.
Springer seminars in immunopathology Sep, 2005 | Pubmed ID: 15931528
Cutting edge: CD4+CD25+ regulatory T cells impaired for intestinal homing can prevent colitis.
Journal of immunology (Baltimore, Md. : 1950) Jun, 2005 | Pubmed ID: 15944246
Lack of chemokine receptor CCR5 promotes murine fulminant liver failure by preventing the apoptosis of activated CD1d-restricted NKT cells.
Journal of immunology (Baltimore, Md. : 1950) Jun, 2005 | Pubmed ID: 15944310
Infection, autoimmunity, and glycolipids: T cells detect microbes through self-recognition.
Immunity Jun, 2005 | Pubmed ID: 15963780
Crystal structure of mouse CD1d bound to the self ligand phosphatidylcholine: a molecular basis for NKT cell activation.
Journal of immunology (Baltimore, Md. : 1950) Jul, 2005 | Pubmed ID: 16002697
Microsomal triglyceride transfer protein lipidation and control of CD1d on antigen-presenting cells.
The Journal of experimental medicine Aug, 2005 | Pubmed ID: 16087713
Phenotypical and functional alterations during the expansion phase of invariant Valpha14 natural killer T (Valpha14i NKT) cells in mice primed with alpha-galactosylceramide.
Immunology Sep, 2005 | Pubmed ID: 16108815
Activation or anergy: NKT cells are stunned by alpha-galactosylceramide.
The Journal of clinical investigation Sep, 2005 | Pubmed ID: 16138189
Carboxylated glycans mediate colitis through activation of NF-kappa B.
Journal of immunology (Baltimore, Md. : 1950) Oct, 2005 | Pubmed ID: 16210648
The proatherogenic role of T cells requires cell division and is dependent on the stage of the disease.
Arteriosclerosis, thrombosis, and vascular biology Feb, 2006 | Pubmed ID: 16322528
Synthesis and evaluation of sphinganine analogues of KRN7000 and OCH.
The Journal of organic chemistry Dec, 2005 | Pubmed ID: 16323834
V alpha14 i NKT cells are innate lymphocytes that participate in the immune response to diverse microbes.
Journal of clinical immunology Nov, 2005 | Pubmed ID: 16380816
Glycolipid activation of invariant T cell receptor+ NK T cells is sufficient to induce airway hyperreactivity independent of conventional CD4+ T cells.
Proceedings of the National Academy of Sciences of the United States of America Feb, 2006 | Pubmed ID: 16478801
Immediate antigen-specific effector functions by TCR-transgenic CD8+ NKT cells.
European journal of immunology Mar, 2006 | Pubmed ID: 16506291
Design of natural killer T cell activators: structure and function of a microbial glycosphingolipid bound to mouse CD1d.
Proceedings of the National Academy of Sciences of the United States of America Mar, 2006 | Pubmed ID: 16537470
CD4+ invariant T-cell-receptor+ natural killer T cells in bronchial asthma.
The New England journal of medicine Mar, 2006 | Pubmed ID: 16540612
Elevated serum anti-I2 and anti-OmpW antibody levels in children with IBD.
Inflammatory bowel diseases May, 2006 | Pubmed ID: 16670528
A unique lymphotoxin {alpha}beta-dependent pathway regulates thymic emigration of V{alpha}14 invariant natural killer T cells.
Proceedings of the National Academy of Sciences of the United States of America Jun, 2006 | Pubmed ID: 16751279
The complementarity determining region 2 of BV8S2 (V beta 8.2) contributes to antigen recognition by rat invariant NKT cell TCR.
Journal of immunology (Baltimore, Md. : 1950) Jun, 2006 | Pubmed ID: 16751390
Anti-mitochondrial antibodies and primary biliary cirrhosis in TGF-beta receptor II dominant-negative mice.
Journal of immunology (Baltimore, Md. : 1950) Aug, 2006 | Pubmed ID: 16849474
Natural killer T cells recognize diacylglycerol antigens from pathogenic bacteria.
Nature immunology Sep, 2006 | Pubmed ID: 16921381
Synergistic costimulation by both B7 molecules regulates colitis pathogenesis.
Annals of the New York Academy of Sciences Aug, 2006 | Pubmed ID: 17057203
Activation of natural killer T cells by glycolipids.
Methods in enzymology , 2006 | Pubmed ID: 17132506
Frontline T cells: gammadelta T cells and intraepithelial lymphocytes.
Immunological reviews Feb, 2007 | Pubmed ID: 17291274
Thymic differentiation of TCR alpha beta(+) CD8 alpha alpha(+) IELs.
Immunological reviews Feb, 2007 | Pubmed ID: 17291288
On the road: progress in finding the unique pathway of invariant NKT cell differentiation.
Current opinion in immunology Apr, 2007 | Pubmed ID: 17303398
Invariant NKT cells amplify the innate immune response to lipopolysaccharide.
Journal of immunology (Baltimore, Md. : 1950) Mar, 2007 | Pubmed ID: 17312112
Mouse TCRalphabeta+CD8alphaalpha intraepithelial lymphocytes express genes that down-regulate their antigen reactivity and suppress immune responses.
Journal of immunology (Baltimore, Md. : 1950) Apr, 2007 | Pubmed ID: 17371979
Natural killer T cells: know thyself.
Proceedings of the National Academy of Sciences of the United States of America Apr, 2007 | Pubmed ID: 17389403
Paradoxical effect of reduced costimulation in T cell-mediated colitis.
Journal of immunology (Baltimore, Md. : 1950) May, 2007 | Pubmed ID: 17442938
The unique role of natural killer T cells in the response to microorganisms.
Nature reviews. Microbiology Jun, 2007 | Pubmed ID: 17487145
Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid.
Science (New York, N.Y.) Jul, 2007 | Pubmed ID: 17569825
Invariant natural killer cells in the response to bacteria: the advent of specific antigens.
Future microbiology Oct, 2006 | Pubmed ID: 17661645
Role of NKT cells in the digestive system. IV. The role of canonical natural killer T cells in mucosal immunity and inflammation.
American journal of physiology. Gastrointestinal and liver physiology Jan, 2008 | Pubmed ID: 17947447
CD1 mediated T cell recognition of glycolipids.
Current opinion in structural biology Oct, 2007 | Pubmed ID: 17951048
Natural killer T cells exacerbate liver injury in a transforming growth factor beta receptor II dominant-negative mouse model of primary biliary cirrhosis.
Hepatology (Baltimore, Md.) Feb, 2008 | Pubmed ID: 18098320
Cutting edge: activation by innate cytokines or microbial antigens can cause arrest of natural killer T cell patrolling of liver sinusoids.
Journal of immunology (Baltimore, Md. : 1950) Feb, 2008 | Pubmed ID: 18250405
Villous B cells of the small intestine are specialized for invariant NK T cell dependence.
Journal of immunology (Baltimore, Md. : 1950) Apr, 2008 | Pubmed ID: 18354186
Abrogation of anti-retinal autoimmunity in IL-10 transgenic mice due to reduced T cell priming and inhibition of disease effector mechanisms.
Journal of immunology (Baltimore, Md. : 1950) Apr, 2008 | Pubmed ID: 18390724
A crucial role for HVEM and BTLA in preventing intestinal inflammation.
The Journal of experimental medicine Jun, 2008 | Pubmed ID: 18519647
Acid test: lipid antigens get into the groove.
Immunity Jun, 2008 | Pubmed ID: 18549793
Natural Sphingomonas glycolipids vary greatly in their ability to activate natural killer T cells.
Chemistry & biology Jul, 2008 | Pubmed ID: 18635002
RAGE, carboxylated glycans and S100A8/A9 play essential roles in colitis-associated carcinogenesis.
Carcinogenesis Oct, 2008 | Pubmed ID: 18689872
Cutting edge: the mechanism of invariant NKT cell responses to viral danger signals.
Journal of immunology (Baltimore, Md. : 1950) Oct, 2008 | Pubmed ID: 18802047
Activation of invariant NKT cells ameliorates experimental ocular autoimmunity by a mechanism involving innate IFN-gamma production and dampening of the adaptive Th1 and Th17 responses.
Journal of immunology (Baltimore, Md. : 1950) Oct, 2008 | Pubmed ID: 18802082
Spontaneous colitis occurrence in transgenic mice with altered B7-mediated costimulation.
Journal of immunology (Baltimore, Md. : 1950) Oct, 2008 | Pubmed ID: 18832683
NKT cells prevent chronic joint inflammation after infection with Borrelia burgdorferi.
Proceedings of the National Academy of Sciences of the United States of America Dec, 2008 | Pubmed ID: 19060201
NKG2A inhibits invariant NKT cell activation in hepatic injury.
Journal of immunology (Baltimore, Md. : 1950) Jan, 2009 | Pubmed ID: 19109156
Detection of microbes by natural killer T cells.
Advances in experimental medicine and biology , 2009 | Pubmed ID: 19209678
Unconventional ligand activation of herpesvirus entry mediator signals cell survival.
Proceedings of the National Academy of Sciences of the United States of America Apr, 2009 | Pubmed ID: 19332782
Retinoic acid can directly promote TGF-beta-mediated Foxp3(+) Treg cell conversion of naive T cells.
Immunity Apr, 2009 | Pubmed ID: 19371709
Regulating the mucosal immune system: the contrasting roles of LIGHT, HVEM, and their various partners.
Seminars in immunopathology Jul, 2009 | Pubmed ID: 19495760
Synthesis and evaluation of 3''- and 4''-deoxy and -fluoro analogs of the immunostimulatory glycolipid, KRN7000.
Bioorganic & medicinal chemistry letters Aug, 2009 | Pubmed ID: 19535248
NKT cells turn ten.
Nature immunology Jul, 2009 | Pubmed ID: 19536187
Carbohydrate specificity of the recognition of diverse glycolipids by natural killer T cells.
Immunological reviews Jul, 2009 | Pubmed ID: 19594637
Innate-like recognition of microbes by invariant natural killer T cells.
Current opinion in immunology Aug, 2009 | Pubmed ID: 19646850
The roles of 3' and 4' hydroxy groups in alpha-galactosylceramide stimulation of invariant natural killer T cells.
ChemMedChem Nov, 2009 | Pubmed ID: 19780098
Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis.
Nature immunology Nov, 2009 | Pubmed ID: 19783988
Mechanisms of NKT cell anergy induction involve Cbl-b-promoted monoubiquitination of CARMA1.
Proceedings of the National Academy of Sciences of the United States of America Oct, 2009 | Pubmed ID: 19815501
Transcriptional regulator Id2 controls survival of hepatic NKT cells.
Proceedings of the National Academy of Sciences of the United States of America Nov, 2009 | Pubmed ID: 19884494
T cell intrinsic heterodimeric complexes between HVEM and BTLA determine receptivity to the surrounding microenvironment.
Journal of immunology (Baltimore, Md. : 1950) Dec, 2009 | Pubmed ID: 19915044
Mechanisms for glycolipid antigen-driven cytokine polarization by Valpha14i NKT cells.
Journal of immunology (Baltimore, Md. : 1950) Jan, 2010 | Pubmed ID: 19949076
Commensal microbiota and CD8+ T cells shape the formation of invariant NKT cells.
Journal of immunology (Baltimore, Md. : 1950) Feb, 2010 | Pubmed ID: 20048124
Lipid binding orientation within CD1d affects recognition of Borrelia burgorferi antigens by NKT cells.
Proceedings of the National Academy of Sciences of the United States of America Jan, 2010 | Pubmed ID: 20080535
A CD1d-dependent antagonist inhibits the activation of invariant NKT cells and prevents development of allergen-induced airway hyperreactivity.
Journal of immunology (Baltimore, Md. : 1950) Feb, 2010 | Pubmed ID: 20083656
Loss of T cell and B cell quiescence precedes the onset of microbial flora-dependent wasting disease and intestinal inflammation in Gimap5-deficient mice.
Journal of immunology (Baltimore, Md. : 1950) Apr, 2010 | Pubmed ID: 20190135
Regulatory B cells prevent and reverse allergic airway inflammation via FoxP3-positive T regulatory cells in a murine model.
The Journal of allergy and clinical immunology May, 2010 | Pubmed ID: 20304473
Co-receptor choice by V alpha14i NKT cells is driven by Th-POK expression rather than avoidance of CD8-mediated negative selection.
The Journal of experimental medicine May, 2010 | Pubmed ID: 20404101
Antigen-specific cytotoxicity by invariant NKT cells in vivo is CD95/CD178-dependent and is correlated with antigenic potency.
Journal of immunology (Baltimore, Md. : 1950) Sep, 2010 | Pubmed ID: 20660713
The Vα14 invariant natural killer T cell TCR forces microbial glycolipids and CD1d into a conserved binding mode.
The Journal of experimental medicine Oct, 2010 | Pubmed ID: 20921281
Regulation of inflammation, autoimmunity, and infection immunity by HVEM-BTLA signaling.
Journal of leukocyte biology Apr, 2011 | Pubmed ID: 21106644
Diverse endogenous antigens for mouse NKT cells: self-antigens that are not glycosphingolipids.
Journal of immunology (Baltimore, Md. : 1950) Feb, 2011 | Pubmed ID: 21191069
Hepatic stellate cells function as regulatory bystanders.
Journal of immunology (Baltimore, Md. : 1950) May, 2011 | Pubmed ID: 21460203
Fibrocyte-like cells recruited to the spleen support innate and adaptive immune responses to acute injury or infection.
Journal of molecular medicine (Berlin, Germany) Oct, 2011 | Pubmed ID: 21499735
Invariant NKT cells are required for airway inflammation induced by environmental antigens.
The Journal of experimental medicine Jun, 2011 | Pubmed ID: 21624935
Invariant natural killer T cells recognize glycolipids from pathogenic Gram-positive bacteria.
Nature immunology Oct, 2011 | Pubmed ID: 21892173
Cooling the fires of inflammation.
Proceedings of the National Academy of Sciences of the United States of America Oct, 2011 | Pubmed ID: 21949393
Mucosal memory CD8⺠T cells are selected in the periphery by an MHC class I molecule.
Nature immunology Nov, 2011 | Pubmed ID: 21964609
Unique interplay between sugar and lipid in determining the antigenic potency of bacterial antigens for NKT cells.
PLoS biology Nov, 2011 | Pubmed ID: 22069376
Glycolipids that elicit IFN-γ-biased responses from natural killer T cells.
Chemistry & biology Dec, 2011 | Pubmed ID: 22195564
Making memory at birth: understanding the differentiation of natural killer T cells.
Current opinion in immunology Feb, 2012 | Pubmed ID: 22305304
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