Rahul Srinivasan
Division of Biology and Biological Engineering
California Institute of Technology (Caltech)
Rahul Srinivasan is an Assistant Professor in the Department of Neuroscience and Experimental Therapeutics, Texas A&M University, College of Medicine. He received his medical degree from the University of Bombay, India, and a Ph.D. from the University of Pittsburgh, USA.
During Dr. Srinivasan's postdoctoral training in Henry Lester's lab at the California Institute of Technology from 2007 to 2013, he showed that low doses of nicotine can chaperone neuronal nicotinic acetylcholine receptors out of the endoplasmic reticulum of dopaminergic neurons, thereby reducing the endoplasmic reticulum stress response. This mechanism of action begins to explain the neuroprotective effect of nicotine in Parkinson's disease. After his postdoctoral training, Dr. Srinivasan moved to Dr. Baljit Khakh's lab at the University of California, Los Angeles where he studied calcium signaling in astrocytes from adult brain slices and in vivo.
As an Assistant Professor at Texas A&M University, Dr. Srinivasan uses mouse models of Parkinson's disease to understand sex differences in the neuroprotective effect of the smoking cessation drug, cytisine. This work is funded by an NIH R01 and by the American Parkinson Disease Association. He also focuses on understanding the role of astrocytes in the pathogenesis of Parkinson's disease.
Engineering an endomorphin-2 gene for use in neuropathic pain therapy.
Pain Dec, 2007 | Pubmed ID: 17395375
An HSV vector system for selection of ligand-gated ion channel modulators.
Nature methods Sep, 2007 | Pubmed ID: 17676048
HSV vectors for gene therapy of chronic pain.
Current opinion in molecular therapeutics Oct, 2008 | Pubmed ID: 18830920
Protein kinase C epsilon contributes to basal and sensitizing responses of TRPV1 to capsaicin in rat dorsal root ganglion neurons.
The European journal of neuroscience Oct, 2008 | Pubmed ID: 18973552
Nicotine is a selective pharmacological chaperone of acetylcholine receptor number and stoichiometry. Implications for drug discovery.
The AAPS journal Mar, 2009 | Pubmed ID: 19280351
Nicotine up-regulates alpha4beta2 nicotinic receptors and ER exit sites via stoichiometry-dependent chaperoning.
The Journal of general physiology Jan, 2011 | Pubmed ID: 21187334
Characterizing functional α6β2 nicotinic acetylcholine receptors in vitro: mutant β2 subunits improve membrane expression, and fluorescent proteins reveal responsive cells.
Biochemical pharmacology Oct, 2011 | Pubmed ID: 21609715
Trafficking of alpha4* nicotinic receptors revealed by superecliptic phluorin: effects of a beta4 amyotrophic lateral sclerosis-associated mutation and chronic exposure to nicotine.
The Journal of biological chemistry Sep, 2011 | Pubmed ID: 21768117
α7β2 nicotinic acetylcholine receptors assemble, function, and are activated primarily via their α7-α7 interfaces.
Molecular pharmacology Feb, 2012 | Pubmed ID: 22039094
Pharmacological chaperoning of nicotinic acetylcholine receptors reduces the endoplasmic reticulum stress response.
Molecular pharmacology Jun, 2012 | Pubmed ID: 22379121
Live-cell imaging of single receptor composition using zero-mode waveguide nanostructures.
Nano letters Jul, 2012 | Pubmed ID: 22668081
Psychiatric drugs bind to classical targets within early exocytotic pathways: therapeutic effects.
Biological psychiatry Dec, 2012 | Pubmed ID: 22771239
Förster resonance energy transfer (FRET) correlates of altered subunit stoichiometry in cys-loop receptors, exemplified by nicotinic α4β2.
International journal of molecular sciences , 2012 | Pubmed ID: 22949846
Transcriptional regulation by nicotine in dopaminergic neurons.
Biochemical pharmacology Oct, 2013 | Pubmed ID: 23939186
Nicotine exploits a COPI-mediated process for chaperone-mediated up-regulation of its receptors.
The Journal of general physiology Jan, 2014 | Pubmed ID: 24378908
Pharmacological chaperoning of nAChRs: a therapeutic target for Parkinson's disease.
Pharmacological research May, 2014 | Pubmed ID: 24593907
Imaging P2X4 receptor subcellular distribution, trafficking, and regulation using P2X4-pHluorin.
The Journal of general physiology Jul, 2014 | Pubmed ID: 24935743
Ca(2+) signaling in astrocytes from Ip3r2(-/-) mice in brain slices and during startle responses in vivo.
Nature neuroscience May, 2015 | Pubmed ID: 25894291
Smoking-Relevant Nicotine Concentration Attenuates the Unfolded Protein Response in Dopaminergic Neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience Jan, 2016 | Pubmed ID: 26740650
New Transgenic Mouse Lines for Selectively Targeting Astrocytes and Studying Calcium Signals in Astrocyte Processes In Situ and In Vivo.
Neuron Dec, 2016 | Pubmed ID: 27939582
Macrophage Migration Inhibitory Factor Alters Functional Properties of CA1 Hippocampal Neurons in Mouse Brain Slices.
International journal of molecular sciences Dec, 2019 | Pubmed ID: 31906137
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