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Department of Structural Biology,
Department of Chemical Biology and Therapeutics
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The X-ray structure of a BAK homodimer reveals an inhibitory zinc binding site.
Molecular cell Dec, 2006 | Pubmed ID: 17157251
Concerted multi-pronged attack by calpastatin to occlude the catalytic cleft of heterodimeric calpains.
Nature Nov, 2008 | Pubmed ID: 19020622
The BCL-2 family reunion.
Molecular cell Feb, 2010 | Pubmed ID: 20159550
Diversifying selection and functional analysis of interleukin-4 suggests antagonism-driven evolution at receptor-binding interfaces.
BMC evolutionary biology Jul, 2010 | Pubmed ID: 20649995
BH3 domains other than Bim and Bid can directly activate Bax/Bak.
The Journal of biological chemistry Jan, 2011 | Pubmed ID: 21041309
A unified model of mammalian BCL-2 protein family interactions at the mitochondria.
Molecular cell Nov, 2011 | Pubmed ID: 22036586
BID-induced structural changes in BAK promote apoptosis.
Nature structural & molecular biology May, 2013 | Pubmed ID: 23604079
Metabolic activation of CaMKII by coenzyme A.
Molecular cell Nov, 2013 | Pubmed ID: 24095281
Many players in BCL-2 family affairs.
Trends in biochemical sciences Mar, 2014 | Pubmed ID: 24503222
Discoveries and controversies in BCL-2 protein-mediated apoptosis.
The FEBS journal 07, 2016 | Pubmed ID: 26411300
Sequential Engagement of Distinct MLKL Phosphatidylinositol-Binding Sites Executes Necroptosis.
Molecular cell Feb, 2016 | Pubmed ID: 26853145
BOK Is a Non-canonical BCL-2 Family Effector of Apoptosis Regulated by ER-Associated Degradation.
Cell Apr, 2016 | Pubmed ID: 26949185
Intrinsic Instability of BOK Enables Membrane Permeabilization in Apoptosis.
Cell reports May, 2018 | Pubmed ID: 29768206
MLKL Requires the Inositol Phosphate Code to Execute Necroptosis.
Molecular cell Jun, 2018 | Pubmed ID: 29883610
St. Jude Children's Research Hospital
Dan E. McNamara*,1,2,
Giovanni Quarato*,3,
Cliff S. Guy3,
Douglas R. Green3,
Tudor Moldoveanu1,2
1Department of Structural Biology, St. Jude Children's Research Hospital,
2Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital,
3Department of Immunology, St. Jude Children's Research Hospital
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