Murine Left Anterior Descending (LAD) Coronary Artery Ligation: An Improved and Simplified Model for Myocardial InfarctionKarla Reichert *1, Bonnie Colantuono *1, Isabella McCormack 1, Fernanda Rodrigues 1, Vasile Pavlov 1, M. Ruhul Abid 1
1Cardiothoracic Surgery Division, Rhode Island Hospital, Brown University Warren Alpert Medical School
We provide a reliable method for left anterior descending artery (LAD) ligation in a mouse model. This method is comparatively less invasive than other methods, involving endotracheal intubation, a left-sided thoracotomy approach, and thoracentesis. This method can be used as a model for both acute and chronic myocardial infarction (MI).
