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Murine Left Anterior Descending (LAD) Coronary Artery Ligation: An Improved and Simplified Model for Myocardial Infarction

DOI :

10.3791/55353-v

April 2nd, 2017

April 2nd, 2017

23,145 Views

1Cardiothoracic Surgery Division, Rhode Island Hospital, Brown University Warren Alpert Medical School

We provide a reliable method for left anterior descending artery (LAD) ligation in a mouse model. This method is comparatively less invasive than other methods, involving endotracheal intubation, a left-sided thoracotomy approach, and thoracentesis. This method can be used as a model for both acute and chronic myocardial infarction (MI).

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Keywords Murine

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