Co-transplantation of Human Ovarian Tissue with Engineered Endothelial Cells: A Cell-based Strategy Combining Accelerated Perfusion with Direct Paracrine Delivery
Bilateral Oophorectomy and Co-transplantation of Human Ovarian Tissue with Engineered Endothelial Cells into NSG Mice
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Results: Co-transplantation of Human Ovarian Tissue with Endothelial Cells
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Conclusion
TRANSCRIÇÃO
The overall goal of this protocol is to xenograft cryopreserved human ovarian tissue in combination with engineered endothelial cells that accelerate re-perfusion and provide paracrine stimulus that modulates follicular activation within the graft
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For some patients, the only option for fertility preservation is cryopreservation of ovarian tissue. Unfortunately, delayed revascularization undermines follicular viability. Here, we present a protocol to co-transplant human ovarian tissue with endothelial cells for utilization as a cell-based strategy combining accelerated perfusion with a direct paracrine delivery of bioactive molecules.