It is difficult to assess sarcomere function in the pluripotent stem cell-derived cardiomyocytes due to their underdeveloped and disorganized sarcomere. Using fluorescent-tagged sarcomere proteins, we can now access sarcomere shortening. We can vi
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This method can be used to examine sarcomere shortening using pluripotent stem cell-derived cardiomyocytes with fluorescent-tagged sarcomere proteins.