Preparation and Characterization of PLGA Nanoparticles
2:38
Preparation and Characterization of PNPE
3:24
bEVs Adhere to the PNPE
5:31
CLSM Analysis of Antigen Uptake
8:14
Results: Affinity of PNPE to bEVs and Uptake of Antigens
9:41
Conclusion
Transcrição
We developed the PLGA nanoparticles stabilized Pickering emulsion. The Pickering emulsion improved the cellular affinity to antigen protein cells, inducing efficient internalization of antigens. The nanoparticle stabilized Pickering emulsions were
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To rationally design efficient adjuvants, we developed poly-lactic-co-glycolic acid nanoparticle-stabilized Pickering emulsion (PNPE). The PNPE possessed unique softness and a hydrophobic interface for potent cellular contact and offered high-content antigen loading, improving the cellular affinity of the delivery system to antigen-presenting cells and inducing efficient internalization of antigens.