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Chapter 40

A Hierarchical Stem-Cell System: Blood Cell Formation

Overview of the Vascular System
Overview of the Vascular System
The vascular system comprises an extensive network of arteries, capillaries, and veins. The vascular system can be broadly divided into the blood and ...
Mechanism of Angiogenesis
Mechanism of Angiogenesis
Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called ...
Regulation of Angiogenesis and Blood Supply
Regulation of Angiogenesis and Blood Supply
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or ...
Hematopoiesis
Hematopoiesis
The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This ...
Multipotency of Hematopoietic Stem Cells
Multipotency of Hematopoietic Stem Cells
The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in ...
Lineage Commitment
Lineage Commitment
Commitment is the  process whereby stem cells:  lose their ability to form all cell types and irreversibly change into a specific type. The ...
Erythropoiesis
Erythropoiesis
Red blood cells  (RBCs) transport oxygen to all body tissues. These cells survive only for 120 days and then need to be replenished. Erythropoiesis ...
Differentiation of Common Myeloid Progenitor Cells
Differentiation of Common Myeloid Progenitor Cells
Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are ...
Regulation of Hematopoietic Stem Cells
Regulation of Hematopoietic Stem Cells
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a ...
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