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Chapter 1

Pharmacokinetics and Pharmacodynamics: Introduction

Biopharmaceutics and Pharmacokinetics: Overview
Biopharmaceutics and Pharmacokinetics: Overview
Drugs come in various dosage forms, including solids, liquids, semisolids, or aerosols. These formulations deliver drugs at the site of action, triggering ...
Pharmacokinetic Models: Overview
Pharmacokinetic Models: Overview
Pharmacokinetic models use mathematical analysis to express a drug's time course in the body. These models can simulate rates of a drug's ...
Drug Concentration Versus Time Correlation
Drug Concentration Versus Time Correlation
Plasma drug levels, plotted at regular intervals, help track its time course in the body. For instance, consider a plot after a single oral dose. The drug ...
Drug Concentrations: Measurements
Drug Concentrations: Measurements
Drug concentration represents the drug amount present in a biological sample. It helps assess the initial drug pharmacokinetics in the body. The samples ...
Fundamental Mathematical Principles in Pharmacokinetics: Calculus and Graphs
Fundamental Mathematical Principles in Pharmacokinetics: Calculus and Graphs
Pharmacokinetic models view drugs within the body as dynamic entities and rely on calculus as a vital tool for quantitative drug movement analysis. ...
Fundamental Mathematical Principles in Pharmacokinetics: Mathematical Expressions and Units
Fundamental Mathematical Principles in Pharmacokinetics: Mathematical Expressions and Units
Mathematical expressions help understand pharmacokinetic parameters by using equations to describe the relationships between different variables. For ...
Fundamental Mathematical Principles in Pharmacokinetics: Rate and Order of Reaction
Fundamental Mathematical Principles in Pharmacokinetics: Rate and Order of Reaction
Pharmacokinetic models incorporate reaction order and rate to comprehend processes such as drug absorption and elimination. In pharmacokinetics, the rate ...
Analysis of Population Pharmacokinetic Data
Analysis of Population Pharmacokinetic Data
Traditional pharmacokinetic methods involve taking multiple samples from a few individuals and estimating pharmacokinetic parameters. Despite their common ...
Pharmacodynamics: Overview and Principles
Pharmacodynamics: Overview and Principles
Pharmacodynamics is the scientific study that explores the biochemical, cellular, and physiological effects of drugs on the body. Most drug effects result ...
Structure-Activity Relationships and Drug Design
Structure-Activity Relationships and Drug Design
Drug design involves discovering new medications based on specific biological targets. It relies on structure-activity relationships, SAR, or quantitative ...
Agonism and Antagonism: Quantification
Agonism and Antagonism: Quantification
Administration of drugs can lead to either agonist or antagonist effect. Agonism occurs when a drug activates a receptor, triggering a biological ...
Drug Control Governance: Regulatory Bodies and Their Impact
Drug Control Governance: Regulatory Bodies and Their Impact
Drug control governance involves global regulatory bodies that standardize and control the safety and efficacy of pharmaceuticals, as well as prevent ...
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