Crop cultivation has a long history in human civilization, with records showing the cultivation of cereal plants beginning at around 8000 BC. This early plant breeding was developed primarily to provide a steady supply of food.

As humans' understanding of genetics advanced, improved crop varieties could be achieved more quickly. Artificial selection could be more directed, and crop varieties enhanced for favorable traits more quickly to produce better, more robust, or more palatable plants.

However, traditional techniques for breeding plants are slow and do not always produce the desired crop varieties. Later, biotechnological tools made it easier to engineer desired traits into plants that are otherwise difficult to breed using traditional methods. For example, improving nutritional deficiency in plants is difficult via artificial selection, and particularly challenging for vitamin A and iron. Rice, for example, does not contain genes for beta carotene, which is a vitamin A precursor. However, it does contain genes for the compound geranylgeranyl pyrophosphate, which can be sequentially converted to beta carotene using four enzymes. Rice was engineered using genes for two enzymes derived from daffodils, and the remaining two enzymes from the bacteria Erwinia uredovora. The resulting crop is known as golden rice. Because rice is the staple food of more than half of the world, bioengineered crops such as these could potentially play a role in preventing blindness among children caused by vitamin A deficiency, or improving the health of rice-reliant countries.

Many commonly grown crop plants now have some degree of genetic modification introduced using biotechnology. For example, maize, papaya, and many potato varieties have been modified for herbicide, disease, or pest resistance. Genetic modification can even be carried out to reduce allergen production, which is the case in soybeans.