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Summary

Ole Isacson gives a concise overview of Parkinsons's disease, its causes, therapeutic strategies, and advances in Parkinson's research.

Abstract

References

  1. Chung, C. Y., Seo, H., Sonntag, K. C., Brooks, A., Lin, L., Iasacson, O. Cell type specific gene expression of midbrain dopaminergic neurons reveals molecules involved in their vulnerability. Hum. Mol. Genet. 14, 1709-1725 (2005).
  2. Mendez, I., Sanchez-Pernaute, R., Cooper, O., Vinuela, A., Ferrari, D., Bjoerklund, L., Dagher, A., Isacson, O. Cell type analysis of fetal dopamine cell suspension transplants in the striatum and substantia nigra of patients with Parkinson's disease. Brain. 128 (7), 1498-1510 (2005).
  3. Cooper, O., Isacson, O. Intrastiatal Transforming Growth Factor Delivery to a Model of Parkinson's Disease Induces Proliferation and Migration of Endogenous Adult Neural Progenitor Cells without Differentiation into Dopaminergic Neurons. J. Neurosci. 24 (41), 8924-8931 (2004).
  4. Sanchez-Pernaute, R., Ferree, A., Cooper, O., Yu, M., Brownell, A. L., Isacson, O. Selective COX-2 inhibition prevents progressive dopamine neuron degeneration in a rat mod of Parkinson's disease. Journal of Neuroinflammation. , (2004).
  5. Isacson, O. The production and use of cells as therapeutic agents in neurodegenerative diseases. Lancet Neurology. 2 (7), 417-424 (2003).

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Ole IsacsonA Renowned ScientistIs Dedicated To The Development Of New Therapies For Parkinson s Disease His Groundbreaking Research Focuses On Finding Innovative Treatments That Can Slow Down Or Even Halt The Progression Of This Debilitating Neurodegenerative Disorder Isacson s Work Involves Understanding The Underlying Mechanisms Of Parkinson s Disease And Identifying Potential Targets For Therapeutic Interventions By Studying The Pathology Of The Disease And Its Impact On Brain CellsHe Aims To Discover Novel Approaches To Prevent The Loss Of Dopamine producing NeuronsWhich Is A Hallmark Of Parkinson s One Of Isacson s Notable Contributions Is In The Field Of Stem Cell Therapy He Has Been At The Forefront Of Utilizing Induced Pluripotent Stem Cells iPSCs To Generate Dopamine producing Neurons In The Laboratory This Breakthrough Technique Holds Immense Promise For Developing Patient specific Cell Replacement TherapiesProviding A Potential Cure For Parkinson s In A

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