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Abstract

Bioengineering

孕妇子宫收缩的肌电图成像

Published: May 26th, 2023

DOI:

10.3791/65214

1Department of Physics, Washington University, 2Center for Reproductive Health Sciences, Washington University School of Medicine, 3Department of Obstetrics and Gynecology, Washington University School of Medicine, 4Department of Biomedical Engineering, Washington University, 5Mallinckrodt Institute of Radiology, Washington University School of Medicine, 6Department of Pediatrics, Washington University School of Medicine, 7Department of Cardiology, Washington University School of Medicine, 8Department of Women's Health, University of Texas at Austin, Dell Medical School

* These authors contributed equally

Abstract

在正常怀孕期间,子宫平滑肌(子宫肌层)在妊娠晚期开始出现微弱、不协调的收缩,以帮助子宫颈重塑。在分娩时,子宫肌层具有强烈、协调的收缩来分娩胎儿。已经开发了各种方法来监测子宫收缩模式以预测分娩开始。然而,目前的技术具有有限的空间覆盖范围和特异性。我们开发了肌电成像 (EMMI),以在宫缩期间无创地将子宫电活动映射到三维子宫表面。EMMI 的第一步是使用 T1 加权磁共振成像来获取受试者特定的身体-子宫几何形状。接下来,使用放置在体表上的多达 192 个针型电极来收集子宫肌层的电记录。最后,执行EMMI数据处理流水线,将体-子宫几何形状与体表电数据相结合,对子宫表面的子宫电活动进行重建和成像。EMMI可以安全、无创地对整个子宫的早期激活区域和传播模式进行三维成像、识别和测量。

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