Mark Bradley

Supported diazonium salts--convenient reagents for the combinatorial synthesis of azo dye.

Solid-phase template-directed synthesis of a [2]rotaxane using a solid-phase stopper.

Enzyme accessibility and solid supports: which molecular weight enzymes can be used on solid supports? An investigation using confocal Raman microscopy.

Fluorescence enhancement through enzymatic cleavage of internally quenched dendritic peptides: a sensitive assay for the AspN endoproteinase.

Recoverable catalysts and reagents using recyclable polystyrene-based supports.

L-arginyl-3,4-spermidine is neuroprotective in several in vitro models of neurodegeneration and in vivo ischaemia without suppressing synaptic transmission.

The combinatorial centre of excellence - a unique industrial academic partnership.

A novel concept of reversing neuromuscular block: chemical encapsulation of rocuronium bromide by a cyclodextrin-based synthetic host.

Which sites react first? Functional site distribution and kinetics on solid supports investigated using confocal Raman and fluorescence microscopy.

Mild and highly chemoselective oxidation of thioethers mediated by Sc(OTf)3.

Ion-extraction ladder sequencing from bead-based libraries.

Synthesis and evaluation of fluorescent probes for the detection of calpain activity.

Characterisation of a novel class of polyamine-based neuroprotective compounds.

Loading amplification of radiation grafted polymers (crowns and lanterns) and their application in the solid-phase synthesis of hydantoin libraries.

Recycling solid supports--a head-to-tail linker.

Dyad beads and the combinatorial discovery of catalysts.

Cell penetrable peptoid carrier vehicles: synthesis and evaluation.

Mass drug treatment for lymphatic filariasis and onchocerciasis.

Parallel and multiplexed bead-based assays and encoding strategies.

Test strip detection of Wuchereria bancrofti amplified DNA in wild-caught Culex pipiens and estimation of infection rate by a PoolScreen algorithm.

Solid-phase synthesis of 89 polyamine-based cationic lipids for DNA delivery to mammalian cells.

Microwaves, supported-reagents and parallel synthesis: isocyanide and ester synthesis.

Self-indicating amine scavenger resins.

The impact of combinatorial methodologies on medicinal chemistry.

Full orthogonality between Dde and Fmoc: the direct synthesis of PNA--peptide conjugates.

Getting more from IR-microscopy of resin-bound libraries.

A combinatorial approach to the synthesis of cystine based organogelators.

pH indicating resins.

Polyborane reactions in ionic liquids: new efficient routes to functionalized decaborane and o-carborane clusters.

Long-lasting reduction of Brugia timori microfilariae following a single dose of diethylcarbamazine combined with albendazole.

DNA transfection screening from single beads.

PS-IIDQ: an efficient polymer-supported amide coupling reagent.

Combinatorial libraries - from solution to 2D microarrays.

Resin bead micro-UV-visible absorption spectroscopy.

Mechanism and structure-activity relationships of norspermidine-based peptidic inhibitors of trypanothione reductase.

Bead-based cellular analysis, sorting and multiplexing.

Synthesis and cellular uptake of cell delivering PNA-peptide conjugates.

High throughput physical organic chemistry: analytical constructs for monomer reactivity profiling.

Impact of two rounds of mass drug administration using diethylcarbamazine combined with albendazole on the prevalence of Brugia timori and of intestinal helminths on Alor Island, Indonesia.

Organotypic cultures as tools for functional screening in the CNS.

An analysis of the feasibility of short read sequencing.

Polymer resin library and the discovery of highly efficient polymer supported reagents and scavengers.

Captured and cross-linked palladium nanoparticles.

Polymer microarrays for cellular adhesion.

Amineborane-based chemical hydrogen storage: enhanced ammonia borane dehydrogenation in ionic liquids.

Polymer microarrays: identification of substrates for phagocytosis assays.

Developing the nurse's role in the care of older people.

High-throughput physical organic chemistry--Hammett parameter evaluation.

Microsphere-based real-time calcium sensing.

Dual colour, microarray-based, analysis of 10,000 protease substrates.

Factors influencing drug compliance in the mass drug administration programme against filariasis in the Western province of Sri Lanka.

Approaches to high throughput physical organic chemistry.

Microarray platforms for enzymatic and cell-based assays.

Multistep synthesis on SU-8: combining microfabrication and solid-phase chemistry on a single material.

Development of self-indicating resin.

Tools for efficient high-throughput synthesis.

Functional peptide arrays for high-throughput chemical biology based applications.

pH sensing in living cells using fluorescent microspheres.

Entangled palladium nanoparticles in resin plugs.

Microscopic infrared mapping of chloromethylated polystyrene resin beads.

A 10,000 member PNA-encoded peptide library for profiling tyrosine kinases.

Screening for polymorphs on polymer microarrays.

Triple co-administration of ivermectin, albendazole and praziquantel in zanzibar: a safety study.

Combining nebulization-mediated transfection and polymer microarrays for the rapid determination of optimal transfection substrates.

Depression symptoms and sexual HIV risk behavior among serodiscordant couples.

Synthesis, penetrability and intracellular targeting of fluorescein-tagged peptoids and peptide-peptoid hybrids.

Inkjet fabrication of hydrogel microarrays using in situ nanolitre-scale polymerisation.

Solid-phase synthesis of a lysine-capped bis-dendron with remarkable DNA delivery abilities.

Tripod-like cationic lipids as novel gene carriers.

Multifunctionalized biocompatible microspheres for sensing.

Dunking doughnuts into cells--selective cellular translocation and in vivo analysis of polymeric micro-doughnuts.

Deciphering cellular morphology and biocompatibility using polymer microarrays.

Double-walled boron nitride nanotubes grown by floating catalyst chemical vapor deposition.

From 10,000 to 1: Selective synthesis and enzymatic evaluation of fluorescence resonance energy transfer peptides as specific substrates for chymopapain.

Determinants of success in national programs to eliminate lymphatic filariasis: a perspective identifying essential elements and research needs.

The global programme to eliminate lymphatic filariasis: health impact after 8 years.

A microarray approach to the identification of polyurethanes for the isolation of human skeletal progenitor cells and augmentation of skeletal cell growth.

High-throughput viscosity determinations.

Very long-chain fatty tails for enhanced transfection.

Versatile biocompatible polymer hydrogels: scaffolds for cell growth.

A cooperative polymer-DNA microarray approach to biomaterial investigation.

Amide bond formation: beyond the myth of coupling reagents.

Inkjet fabrication of polymer microarrays and grids--solving the evaporation problem.

Catch and release microwave mediated synthesis of cyanine dyes.

Knocking (anti)-sense into cells: the microsphere approach to gene silencing.

A case-building Spirostomum (Ciliophora, Heterotrichida) with zoochlorellae.

Assessing transmission of lymphatic filariasis using parasitologic, serologic, and entomologic tools after mass drug administration in American Samoa.

Xenomonitoring of Wuchereria bancrofti and Dirofilaria immitis infections in mosquitoes from American Samoa: trapping considerations and a comparison of polymerase chain reaction assays with dissection.

Microsphere-mediated protein delivery into cells.

Microwave-assisted ester formation using O-alkylisoureas: a convenient method for the synthesis of esters with inversion of configuration.

Microspheres as a vehicle for biomolecule delivery to neural stem cells.

Fingerprinting polymer microarrays.

Lack of understanding of acute HIV infection among newly-infected persons-implications for prevention and public health: The NIMH Multisite Acute HIV Infection Study: II.

Microsphere-based tracing and molecular delivery in embryonic stem cells.

Microarrays of over 2000 hydrogels--identification of substrates for cellular trapping and thermally triggered release.

Albendazole and its metabolites in the breast milk of lactating women following a single oral dose of albendazole.

Laser printing mediated cell patterning.

Strategies for cell manipulation and skeletal tissue engineering using high-throughput polymer blend formulation and microarray techniques.

Investigation of microsphere-mediated cellular delivery by chemical, microscopic and gene expression analysis.

DNA analysis by dynamic chemistry.

Diffusion in a two-dimensional channel with curved midline and varying width: reduction to an effective one-dimensional description.

The economic benefits resulting from the first 8 years of the Global Programme to Eliminate Lymphatic Filariasis (2000-2007).

Novel antibacterial nanofibrous PLLA scaffolds.

Ciliates in chalk-stream habitats congregate in biodiversity hot spots.

Metal oxide nanoparticles induce unique inflammatory footprints in the lung: important implications for nanoparticle testing.

The role of translocation in recovery of woodland caribou populations.

Spontaneous pattern formation induced by ion bombardment of binary compounds.

Zeta potential mediated reaction monitoring on nano and microparticles.

Unbiased screening of polymer libraries to define novel substrates for functional hepatocytes with inducible drug metabolism.

Differential pro-inflammatory effects of metal oxide nanoparticles and their soluble ions in vitro and in vivo; zinc and copper nanoparticles, but not their ions, recruit eosinophils to the lungs.

Palladium-mediated intracellular chemistry.

Multi-modal molecular imaging approaches to detect primary cells in preclinical models.

Strategies for the preparation of synthetic transfection vectors.

Encoded peptide libraries and the discovery of new cell binding ligands.

Screening of a combinatorial homing peptide library for selective cellular delivery.

Polymers for the rapid and effective activation and aggregation of platelets.

Lineage-specific distribution of high levels of genomic 5-hydroxymethylcytosine in mammalian development.

Progressive severe lung injury by zinc oxide nanoparticles; the role of Zn2+ dissolution inside lysosomes.

Microarray generation of thousand-member oligonucleotide libraries.

Decoding a PNA encoded peptide library by PCR: the discovery of new cell surface receptor ligands.

Solid-phase synthesis of arginine-based double-tailed cationic lipopeptides: potent nucleic acid carriers.

Polymerizable fluorescein derivatives: synthesis of fluorescent particles and their cellular uptake.

Zeta potential and solubility to toxic ions as mechanisms of lung inflammation caused by metal/metal oxide nanoparticles.

Targeting Cryptosporidium parvum capture.

A multicenter evaluation of diagnostic tools to define endpoints for programs to eliminate bancroftian filariasis.

DHEA and cognition in HIV-positive patients with non-major depression.

Analysis of Giardia lamblia interactions with polymer surfaces using a microarray approach.

The use of solid supports to generate nucleic acid carriers.

Peptides for cell-selective drug delivery.

Degree of conversion and microhardness of TPO-containing resin-based composites cured by polywave and monowave LED units.

Fabrication of arrays of polymer gradients using inkjet printing.

Biocompatible polymer nanoparticles for intra-cellular applications.

Synthesis of polystyrene microspheres and functionalization with Pd(0) nanoparticles to perform bioorthogonal organometallic chemistry in living cells.

Transcending scale dependence in identifying habitat with resource selection functions.

A role for intracellular calcium downstream of G-protein signaling in undifferentiated human embryonic stem cell culture.

A highly sensitive fluorescent viscosity sensor.

Novel biochip platform for nucleic acid analysis.

Novel biopolymers to enhance endothelialisation of intra-vascular devices.

A thermoresponsive and chemically defined hydrogel for long-term culture of human embryonic stem cells.

Surface functionalization affects the zeta potential, coronal stability and membranolytic activity of polymeric nanoparticles.

Transcription forms and remodels supercoiling domains unfolding large-scale chromatin structures.

Polymers for the cell-specific immobilisation of megakaryocytic cell lines.

Maintaining hepatic stem cell gene expression on biological and synthetic substrata.

Synthesis and characterization of dual-functionalized core-shell fluorescent microspheres for bioconjugation and cellular delivery.

Methylmercury egg injections: part 2--pathology, neurochemistry, and behavior in the avian embryo and hatchling.

Influence of spacer length on the cellular uptake of polymeric nanoparticles.

Highly specific, multi-branched fluorescent reporters for analysis of human neutrophil elastase.

Knowledge and practice related to compliance with mass drug administration during the Egyptian national filariasis elimination program.

Developing high-fidelity hepatotoxicity models from pluripotent stem cells.

Linking habitat selection and predation risk to spatial variation in survival.

Predictive value of in vitro assays depends on the mechanism of toxicity of metal oxide nanoparticles.

A conserved Oct4/POUV-dependent network links adhesion and migration to progenitor maintenance.

Impact of six rounds of mass drug administration on Brugian filariasis and soil-transmitted helminth infections in eastern Indonesia.

High-density polymer microarrays: identifying synthetic polymers that control human embryonic stem cell growth.

CD133+ cancer stem-like cells in small cell lung cancer are highly tumorigenic and chemoresistant but sensitive to a novel neuropeptide antagonist.

Extracellular palladium-catalysed dealkylation of 5-fluoro-1-propargyl-uracil as a bioorthogonally activated prodrug approach.

Microsphere-based intracellular sensing of caspase-3/7 in apoptotic living cells.

Long term mesenchymal stem cell culture on a defined synthetic substrate with enzyme free passaging.

Separating the isomers--efficient synthesis of the N-hydroxysuccinimide esters of 5 and 6-carboxyfluorescein diacetate and 5 and 6-carboxyrhodamine B.

Development and bioorthogonal activation of palladium-labile prodrugs of gemcitabine.

Photoluminescent carbon dots from 1,4-addition polymers.

Palladium-mediated chemistry in living cells.

Multidimensional complexities of filariasis control in an era of large-scale mass drug administration programmes: a can of worms.

Assessing progress in reducing the at-risk population after 13 years of the global programme to eliminate lymphatic filariasis.

Theory of terraced topographies produced by oblique-incidence ion bombardment of solid surfaces.

Flow-mediated synthesis of Boc, Fmoc, and Ddiv monoprotected diamines.

Bacteria repelling poly(methylmethacrylate-co-dimethylacrylamide) coatings for biomedical devices†Electronic supplementary information (ESI) available: Polymer microarray screening, including analysis of bacterial adhesion by fluorescence microscopy and SEM, and chemical composition of bacteria repelling polymers identified in the screen; polymer synthesis and characterisation; preparation of catheter pieces and solvent studies, and details for confocal imaging/analysis. See DOI: 10.1039/c4tb01129eClick here for additional data file.

Influence of the chirality of short peptide supramolecular hydrogels in protein crystallogenesis.

Large animal in vivo evaluation of a binary blend polymer scaffold for skeletal tissue-engineering strategies; translational issues.

Surface charge determines the lung inflammogenicity: A study with polystyrene nanoparticles.

Enhancing Cryptosporidium parvum recovery rates for improved water monitoring.

Polymer Supported Directed Differentiation Reveals a Unique Gene Signature Predicting Stable Hepatocyte Performance.

Nanoscale patterns formed by ion bombardment of rotating binary materials.

Flow and Microwave-Assisted Synthesis of N-(Triethylene glycol)glycine Oligomers and Their Remarkable Cellular Transporter Activities.

In ovo exposure to organophosphorous flame retardants: survival, development, neurochemical, and behavioral changes in white leghorn chickens.

Polyurethane: Stable Cell Phenotype Requires Plasticity: Polymer Supported Directed Differentiation Reveals a Unique Gene Signature Predicting Stable Hepatocyte Performance (Adv. Healthcare Mater. 12/2015).

Thermoresponsive hydrogel maintains the mouse embryonic stem cell "naïve" pluripotency phenotype.

Methylene blue not ferrocene: Optimal reporters for electrochemical detection of protease activity.

Arrays of 3D double-network hydrogels for the high-throughput discovery of materials with enhanced physical and biological properties.

Eliminating caspase-7 and cathepsin B cross-reactivity on fluorogenic caspase-3 substrates.

Producing nanodot arrays with improved hexagonal order by patterning surfaces before ion sputtering.

A Synthetic Polymer Scaffold Reveals the Self-Maintenance Strategies of Rat Glioma Stem Cells by Organization of the Advantageous Niche.

Bioaccessibility and bioavailability of methylmercury from seafood commonly consumed in North America: In vitro and epidemiological studies.

Red-Fluorescent Activatable Probes for the Detection of Hydrogen Peroxide in Living Cells.

Fluorescent Formazans and Tetrazolium Salts - Towards Fluorescent Cytotoxicity Assays.

Highly ordered square arrays of nanoscale pyramids produced by ion bombardment of a crystalline binary material.

Two-color widefield fluorescence microendoscopy enables multiplexed molecular imaging in the alveolar space of human lung tissue.

Fluorogenic Substrates for In Situ Monitoring of Caspase-3 Activity in Live Cells.

Producing virtually defect-free nanoscale ripples by ion bombardment of rocked solid surfaces.

Optical imaging of bacterial infections.

The health and economic benefits of the global programme to eliminate lymphatic filariasis (2000-2014).

Tuning the emission properties of a fluorescent polymer using a polymer microarray approach - identification of an optothermo responsive polymer.

Dual contribution of surface charge and protein-binding affinity to the cytotoxicity of polystyrene nanoparticles in nonphagocytic A549 cells and phagocytic THP-1 cells.

Nanoparticle "switch-on" by tetrazine triggering.

Use of Granulocyte Colony-Stimulating Factor in a Neutropenic HIV-Infected Patient on Clozapine.

Searching for the optimal fluorophore to label antimicrobial peptides.

Fortified interpenetrating polymers - bacteria resistant coatings for medical devices.

Novel bead-based platform for direct detection of unlabelled nucleic acids through Single Nucleobase Labelling.

Understanding Polymer-Cell Attachment.

Copper Catalysis in Living Systems and In Situ Drug Synthesis.

Tetrazine-Responsive Self-immolative Linkers.

Palladium-mediated in situ synthesis of an anticancer agent.

Synthesis and characterization of biodegradable poly(ether-ester) urethane acrylates for controlled drug release.

Poly(ethylmethacrylate-co-diethylaminoethyl acrylate) coating improves endothelial re-population, bio-mechanical and anti-thrombogenic properties of decellularized carotid arteries for blood vessel replacement.

Highly selective and rapidly activatable fluorogenic Thrombin sensors and application in human lung tissue.

In-Cell Dual Drug Synthesis by Cancer-Targeting Palladium Catalysts.

Intracellular delivery of a catalytic organometallic complex.

Controlled core-to-core photo-polymerisation - fabrication of an optical fibre-based pH sensor.

Peptides for optical medical imaging and steps towards therapy.