Hugues Lortat-Jacob

Sulfated polysaccharides increase plasma levels of SDF-1 in monkeys and mice: involvement in mobilization of stem/progenitor cells.

Structural diversity of heparan sulfate binding domains in chemokines.

Heparan sulfate-mediated binding of infectious dengue virus type 2 and yellow fever virus.

Cell membrane GM1 ganglioside is a functional coreceptor for fibroblast growth factor 2.

Cellular glycosaminoglycans and low density lipoprotein receptor are involved in hepatitis C virus adsorption.

Heparin-aggregated RANTES can be crystallised.

Human cytomegalovirus binding to DC-SIGN is required for dendritic cell infection and target cell trans-infection.

Adenovirus protein involved in virus internalization recruits ubiquitin-protein ligases.

A kinetics and modeling study of RANTES(9-68) binding to heparin reveals a mechanism of cooperative oligomerization.

DC-SIGN and L-SIGN are high affinity binding receptors for hepatitis C virus glycoprotein E2.

Normal human keratinocytes bind to the alpha3LG4/5 domain of unprocessed laminin-5 through the receptor syndecan-1.

Characterization of endostatin binding to heparin and heparan sulfate by surface plasmon resonance and molecular modeling: role of divalent cations.

Heparan sulfate proteoglycan mediates the selective attachment and internalization of serotype 3 human adenovirus dodecahedron.

NMR characterization of the interaction between the C-terminal domain of interferon-gamma and heparin-derived oligosaccharides.

Heparan sulfate/heparin oligosaccharides protect stromal cell-derived factor-1 (SDF-1)/CXCL12 against proteolysis induced by CD26/dipeptidyl peptidase IV.

Synthesis of tailor-made glycoconjugate mimetics of heparan sulfate that bind IFN-gamma in the nanomolar range.

A novel strategy for defining critical amino acid residues involved in protein/glycosaminoglycan interactions.

Glycosaminoglycans and protein disulfide isomerase-mediated reduction of HIV Env.

Heparan sulfate targets the HIV-1 envelope glycoprotein gp120 coreceptor binding site.

The fucose-binding lectin from Ralstonia solanacearum. A new type of beta-propeller architecture formed by oligomerization and interacting with fucoside, fucosyllactose, and plant xyloglucan.

Heparan sulfate mimicry: a synthetic glycoconjugate that recognizes the heparin binding domain of interferon-gamma inhibits the cytokine activity.

Heparan sulphate proteoglycans and viral vectors : ally or foe?

Mannose hyperbranched dendritic polymers interact with clustered organization of DC-SIGN and inhibit gp120 binding.

Structural and mutational analysis of human Ad37 and canine adenovirus 2 fiber heads in complex with the D1 domain of coxsackie and adenovirus receptor.

Organization of human interferon gamma-heparin complexes from solution properties and hydrodynamics.

Structural view of glycosaminoglycan-protein interactions.

Adenovirus dodecahedron cell attachment and entry are mediated by heparan sulfate and integrins and vary along the cell cycle.

The novel CXCL12gamma isoform encodes an unstructured cationic domain which regulates bioactivity and interaction with both glycosaminoglycans and CXCR4.

Efficient long-term and high-yielded production of a recombinant proteoglycan in eukaryotic HEK293 cells using a membrane-based bioreactor.

Relationships between glycosaminoglycan and receptor binding sites in chemokines-the CXCL12 example.

Polypyrrole oligosaccharide array and surface plasmon resonance imaging for the measurement of glycosaminoglycan binding interactions.

The HIV-1 envelope glycoprotein gp120 features four heparan sulfate binding domains, including the co-receptor binding site.

Direct peptide interaction with surface glycosaminoglycans contributes to the cell penetration of maurocalcine.

The CXCL12gamma chemokine displays unprecedented structural and functional properties that make it a paradigm of chemoattractant proteins.

The cell adhesion molecule "CAR" and sialic acid on human erythrocytes influence adenovirus in vivo biodistribution.

Tyrosine dephosphorylation of the syndecan-1 PDZ binding domain regulates syntenin-1 recruitment.

The signal peptide of Staphylococcus aureus panton valentine leukocidin LukS component mediates increased adhesion to heparan sulfates.

Heparan sulfate proteoglycans are receptors for the cell-surface trafficking and biological activity of transglutaminase-2.

Structure and functional relevance of the Slit2 homodimerization domain.

A synthetic CD4-heparan sulfate glycoconjugate inhibits CCR5 and CXCR4 HIV-1 attachment and entry.

The molecular basis and functional implications of chemokine interactions with heparan sulphate.

HABA-based ionic liquid matrices for UV-MALDI-MS analysis of heparin and heparan sulfate oligosaccharides.

A cell-penetrating peptide derived from human lactoferrin with conformation-dependent uptake efficiency.

Dynamics of heparan sulfate explored by neutron scattering.

Cutting edge: C1q binds deoxyribose and heparan sulfate through neighboring sites of its recognition domain.

Characterization and binding activity of the chondroitin/dermatan sulfate chain from Endocan, a soluble endothelial proteoglycan.

Identification of tubular heparan sulfate as a docking platform for the alternative complement component properdin in proteinuric renal disease.

Hijacking of the pleiotropic cytokine interferon-γ by the type III secretion system of Yersinia pestis.

13C-labeled heparan sulfate analogue as a tool to study protein/heparan sulfate interactions by NMR spectroscopy: application to the CXCL12α chemokine.

Cxcl12 evolution--subfunctionalization of a ligand through altered interaction with the chemokine receptor.

Semen clusterin is a novel DC-SIGN ligand.

A synthetic heparan sulfate-mimetic peptide conjugated to a mini CD4 displays very high anti- HIV-1 activity independently of coreceptor usage.

Cell surface proteoglycans syndecan-1 and -4 bind overlapping but distinct sites in laminin α3 LG45 protein domain.

Transglutaminase-2 interaction with heparin: identification of a heparin binding site that regulates cell adhesion to fibronectin-transglutaminase-2 matrix.

Factor h and properdin recognize different epitopes on renal tubular epithelial heparan sulfate.

Continuous evolution profiles for electronic-tongue-based analysis.

Homeostatic and tissue reparation defaults in mice carrying selective genetic invalidation of CXCL12/proteoglycan interactions.

A New C-Xyloside induces modifications of GAG expression, structure and functional properties.

Toward libraries of biotinylated chondroitin sulfate analogues: from synthesis to in vivo studies.

Inflammatory chemokines direct and restrict leukocyte migration within live tissues as glycan-bound gradients.

HSulf sulfatases catalyze processive and oriented 6-O-desulfation of heparan sulfate that differentially regulates fibroblast growth factor activity.

Insights into the mechanism by which interferon-γ basic amino acid clusters mediate protein binding to heparan sulfate.

The disulfide bond between cysteine 10 and cysteine 34 is required for CCL18 activity.

Human immunodeficiency virus and heparan sulfate: from attachment to entry inhibition.

Post-Synthetic Regulation of HS Structure: The Yin and Yang of the Sulfs in Cancer.

The effect of delivering the chemokine SDF-1α in a matrix-bound manner on myogenesis.

Importance of the polarity of the glycosaminoglycan chain on the interaction with FGF-1.

Well-defined biomimetic surfaces to characterize glycosaminoglycan-mediated interactions on the molecular, supramolecular and cellular levels.