Matthias Ernst

LIF receptor signaling limits immune-mediated demyelination by enhancing oligodendrocyte survival.

Analysis of the regulation of the A33 antigen gene reveals intestine-specific mechanisms of gene expression.

Constitutive activation of the SRC family kinase Hck results in spontaneous pulmonary inflammation and an enhanced innate immune response.

Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant mice.

Response of Apc(min) and A33 (delta N beta-cat) mutant mice to treatment with tea, sulindac, and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP).

Hematopoietic abnormalities in mice deficient in gp130-mediated STAT signaling.

AACR special meeting in cancer research: colon cancer--genetics to prevention.

Determination of internuclear distances in uniformly labeled molecules by rotational-resonance solid-state NMR.

The role of the interleukin-6 family of cytokines in inflammatory arthritis and bone turnover.

Heteronuclear spin decoupling in solid-state NMR under magic-angle sample spinning.

Low-power XiX decoupling in MAS NMR experiments.

The role of gp130/IL-6 cytokines in the development of pulmonary fibrosis: critical determinants of disease susceptibility and progression?

NMR spectra of a microcrystalline protein at 30 kHz MAS.

Acquiring signalling specificity from the cytokine receptor gp130.

Gastric cancer development in mice lacking the SHP2 binding site on the IL-6 family co-receptor gp130.

Imbalanced gp130-dependent signaling in macrophages alters macrophage colony-stimulating factor responsiveness via regulation of c-fms expression.

Glycoprotein 130 regulates bone turnover and bone size by distinct downstream signaling pathways.

Low-power high-resolution solid-state NMR of peptides and proteins.

Rotational-resonance distance measurements in multi-spin systems.

Mammary gland remodeling depends on gp130 signaling through Stat3 and MAPK.

Constitutive activation of gp130 leads to neuroendocrine differentiation in vitro and in vivo.

The threshold of gp130-dependent STAT3 signaling is critical for normal regulation of hematopoiesis.

High-resolution solid-state NMR spectroscopy of the prion protein HET-s in its amyloid conformation.

Interleukin-11 receptor signaling is required for normal bone remodeling.

Correlation of structural elements and infectivity of the HET-s prion.

IL-6 trans-signaling via STAT3 directs T cell infiltration in acute inflammation.

Hyperactivation of Stat3 in gp130 mutant mice promotes gastric hyperproliferation and desensitizes TGF-beta signaling.

Decoupling and recoupling using continuous-wave irradiation in magic-angle-spinning solid-state NMR: a unified description using bimodal Floquet theory.

Differential regulation of gastric tumor growth by cytokines that signal exclusively through the coreceptor gp130.

Amplitude-modulated decoupling in rotating solids: a bimodal Floquet approach.

13C, 15N resonance assignment of parts of the HET-s prion protein in its amyloid form.

CNTF reverses obesity-induced insulin resistance by activating skeletal muscle AMPK.

Forced dimerization of gp130 leads to constitutive STAT3 activation, cytokine-independent growth, and blockade of differentiation of embryonic stem cells.

DNA-methylation-dependent alterations of claudin-4 expression in human bladder carcinoma.

Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system.

Observation of highly flexible residues in amyloid fibrils of the HET-s prion.

STAT3 activation regulates growth, inflammation, and vascularization in a mouse model of gastric tumorigenesis.

Pathologic consequences of STAT3 hyperactivation by IL-6 and IL-11 during hematopoiesis and lymphopoiesis.

General nature of the STAT3-activated anti-inflammatory response.

STAT3 is required for IL-6-gp130-dependent activation of hepcidin in vivo.

Opposing roles of gp130-mediated STAT-3 and ERK-1/ 2 signaling in liver progenitor cell migration and proliferation.

c-Myb is required for progenitor cell homeostasis in colonic crypts.

TGF-betaRII rescues development of small intestinal epithelial cells in Elf3-deficient mice.

Suppressor of cytokine signaling 3 regulates CD8 T-cell proliferation by inhibition of interleukins 6 and 27.

Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10.

Operator-based triple-mode Floquet theory in solid-state NMR.

IL6/sIL6R complex contributes to emergency granulopoietic responses in G-CSF- and GM-CSF-deficient mice.

Molecular dissection of gp130-dependent pathways in hepatocytes during liver regeneration.

Mechanism of crosstalk inhibition of IL-6 signaling in response to LPS and TNFalpha.

Insights into homonuclear decoupling from efficient numerical simulation: techniques and examples.

Identification of putative targets of DNA (cytosine-5) methylation-mediated transcriptional silencing using a novel conditionally active form of DNA methyltransferase 3a.

STAT3 and STAT1 mediate IL-11-dependent and inflammation-associated gastric tumorigenesis in gp130 receptor mutant mice.

IL-6 regulates neutrophil trafficking during acute inflammation via STAT3.

Therapeutic targeting of IL-6 trans signaling counteracts STAT3 control of experimental inflammatory arthritis.

The interleukin-6 family cytokine interleukin-11 regulates homeostatic epithelial cell turnover and promotes gastric tumor development.

Ciliary neurotrophic factor stimulates muscle glucose uptake by a PI3-kinase-dependent pathway that is impaired with obesity.

gp130-mediated Stat3 activation in enterocytes regulates cell survival and cell-cycle progression during colitis-associated tumorigenesis.

Dipolar truncation in magic-angle spinning NMR recoupling experiments.

Understanding two-pulse phase-modulated decoupling in solid-state NMR.

Elevated Dnmt3a activity promotes polyposis in Apc(Min) mice by relaxing extracellular restraints on Wnt signaling.

Development and assessment of a short-range meta-GGA functional.

Optimal preparation methods for automated matrix-assisted laser desorption/ionization time-of-flight mass spectrometry profiling of low molecular weight proteins and peptides.

A33 antigen-deficient mice have defective colonic mucosal repair.

Complex hydrides with (BH(4))(-) and (NH(2))(-) anions as new lithium fast-ion conductors.

Direct detection of (3h)J(NC') hydrogen-bond scalar couplings in proteins by solid-state NMR spectroscopy.

Genetic dissection of differential signaling threshold requirements for the Wnt/beta-catenin pathway in vivo.

Involvement of gp130-associated cytokine signaling in Müller cell activation following optic nerve lesion.

Stat3: linking inflammation to epithelial cancer - more than a "gut" feeling?

Operator-based Floquet theory in solid-state NMR.

Continuous glycoprotein-130-mediated signal transducer and activator of transcription-3 activation promotes inflammation, left ventricular rupture, and adverse outcome in subacute myocardial infarction.

More than a sidekick: the IL-6 family cytokine IL-11 links inflammation to cancer.

Characteristics of zero-quantum correlation spectroscopy in MAS NMR experiments.

Quantitative analysis of protein backbone dynamics in microcrystalline ubiquitin by solid-state NMR spectroscopy.

IL-6 trans-signaling modulates TLR4-dependent inflammatory responses via STAT3.

Interleukin-6 promotes pulmonary emphysema associated with apoptosis in mice.

Smad3 dosage determines androgen responsiveness and sets the pace of postnatal testis development.

A proton-detected 4D solid-state NMR experiment for protein structure determination.

Accurate measurement of one-bond H-X heteronuclear dipolar couplings in MAS solid-state NMR.

Gp130-dependent astrocytic survival is critical for the control of autoimmune central nervous system inflammation.

Rotational motion in LiBH4/LiI solid solutions.

PHLDA1 expression marks the putative epithelial stem cells and contributes to intestinal tumorigenesis.

The amyloid-Congo red interface at atomic resolution.

IL-6 mediates the susceptibility of glycoprotein 130 hypermorphs to Toxoplasma gondii.

LPS hypersensitivity of gp130 mutant mice is independent of elevated haemopoietic TLR4 signaling.

Solid-state NMR measurements of asymmetric dipolar couplings provide insight into protein side-chain motion.

Cancer research: past, present and future.

Second-order dipolar order in magic-angle spinning nuclear magnetic resonance.

A supplementary coil for ²H decoupling with commercial HCN MAS probes.

IL-10-induced gp130 expression in mouse mast cells permits IL-6 trans-signaling.

A multi-sample 94 GHz dissolution dynamic-nuclear-polarization system.

Colorectal cancer mouse models: integrating inflammation and the stroma.

Stat3: linking inflammation to (gastrointestinal) tumourigenesis.

Interleukin-11 links oxidative stress and compensatory proliferation.

Comparative 2D DIGE analysis of the depleted serum proteome for biomarker discovery.

Simultaneous acquisition of PAR and PAIN spectra.

Properties of the DREAM scheme and its optimization for application to proteins.

Genetic partitioning of interleukin-6 signalling in mice dissociates Stat3 from Smad3-mediated lung fibrosis.

2D-DIGE analysis of sera from transgenic mouse models reveals novel candidate protein biomarkers for human gastric cancer.

Site-resolved measurement of microsecond-to-millisecond conformational-exchange processes in proteins by solid-state NMR spectroscopy.

Research in magnetic resonance.

Enhanced lithium-induced brain recovery following cranial irradiation is not impeded by inflammation.

mTORC1 inhibition restricts inflammation-associated gastrointestinal tumorigenesis in mice.

Accelerating hyperpolarized metabolic imaging of the heart by exploiting spatiotemporal correlations.

PAIN with and without PAR: variants for third-spin assisted heteronuclear polarization transfer.

Interleukin-6 trans-signaling exacerbates inflammation and renal pathology in lupus-prone mice.

Critical and independent role for SOCS3 in either myeloid or T cells in resistance to Mycobacterium tuberculosis.

Interleukin-11 Is the Dominant IL-6 Family Cytokine during Gastrointestinal Tumorigenesis and Can Be Targeted Therapeutically.

Targeting IL-11 signaling in colon cancer.

Adiabatic Rotor-Echo-Short-Pulse-Irradiation mediated cross-polarization.

Physiological expression of the PI3K-activating mutation Pik3ca(H1047R) combines with Apc loss to promote development of invasive intestinal adenocarcinomas in mice.

Improved decoupling during symmetry-based C9-TOBSY sequences.

Therapeutic inhibition of Jak activity inhibits progression of gastrointestinal tumors in mice.

Low-power polarization transfer between deuterons and spin-1/2 nuclei using adiabatic (RESPIRATION)CP in solid-state NMR.

Epithelial gp130/Stat3 functions: an intestinal signaling node in health and disease.

Identification and validation of novel candidate protein biomarkers for the detection of human gastric cancer.

RIPK1 regulates RIPK3-MLKL-driven systemic inflammation and emergency hematopoiesis.

Hybrid multiband excitation multiecho acquisition for hyperpolarized (13) C spectroscopic imaging.

Quantitative intratumoural microdistribution and kinetics of (131)I-huA33 antibody in patients with colorectal carcinoma.

Spectral editing through laser-flash excitation in two-dimensional photo-CIDNP MAS NMR experiments.

Molecular pathways: IL11 as a tumor-promoting cytokine-translational implications for cancers.

The tyrosine kinase Lyn limits the cytokine responsiveness of plasma cells to restrict their accumulation in mice.

Cross-polarization for dissolution dynamic nuclear polarization.

De novo 3D structure determination from sub-milligram protein samples by solid-state 100 kHz MAS NMR spectroscopy.

Partial inhibition of gp130-Jak-Stat3 signaling prevents Wnt-β-catenin-mediated intestinal tumor growth and regeneration.

IL-17 cuts to the chase in colon cancer.

Asynchronous symmetry-based sequences for homonuclear dipolar recoupling in solid-state nuclear magnetic resonance.