James Koropatnick

Reduction of copper and metallothionein in toxic milk mice by tetrathiomolybdate, but not deferiprone.

The means to an end of tumor cell resistance to chemotherapeutic drugs targeting thymidylate synthase: shoot the messenger.

A sensitive time-resolved fluorescent immunoassay for metallothionein protein.

A "combination oligonucleotide" antisense strategy to downregulate thymidylate synthase and decrease tumor cell growth and drug resistance.

Signaling events for metallothionein induction.

Metallothionein mediates the level and activity of nuclear factor kappa B in murine fibroblasts.

Use of the humanized anti-epidermal growth factor receptor monoclonal antibody h-R3 in combination with radiotherapy in the treatment of locally advanced head and neck cancer patients.

A flavonoid fraction from cranberry extract inhibits proliferation of human tumor cell lines.

Toxicology of antisense therapeutics.

Therapeutic potential of antisense oligodeoxynucleotides to down-regulate thymidylate synthase in mesothelioma.

Reinstalling antitumor immunity by inhibiting tumor-derived immunosuppressive molecule IDO through RNA interference.

In vivo inhibition of growth of human tumor lines by flavonoid fractions from cranberry extract.

Tangeretin and nobiletin induce G1 cell cycle arrest but not apoptosis in human breast and colon cancer cells.

The hyaluronan receptors CD44 and Rhamm (CD168) form complexes with ERK1,2 that sustain high basal motility in breast cancer cells.

Combination silencer RNA (siRNA) targeting Bcl-2 antagonizes siRNA against thymidylate synthase in human tumor cell lines.

Mouse monocytes (RAW CELLS) and the handling of cysteine and homocysteine S-conjugates of inorganic mercury and methylmercury.

Induction of functional MT1 and MT2 isoforms by calcium in anaplastic thyroid carcinoma cells.

Antisense targeting of thymidylate synthase (TS) mRNA increases TS gene transcription and TS protein: effects on human tumor cell sensitivity to TS enzyme-inhibiting drugs.

ODN 491, a novel antisense oligodeoxynucleotide that targets thymidylate synthase, exerts cell-specific effects in human tumor cell lines.

Exosomes as a tumor immune escape mechanism: possible therapeutic implications.

Enhancement of cytotoxicity of natural product drugs against multidrug resistant variant cell lines of human head and neck squamous cell carcinoma and breast carcinoma by tesmilifene.

Expression of functional metallothionein isoforms in papillary thyroid cancer.

Intravenous ascorbic acid to prevent and treat cancer-associated sepsis?

Imaging of homeostatic, neoplastic, and injured tissues by HA-based probes.

Detection of circulating tumor cells in advanced head and neck cancer using the CellSearch system.

Reduction of tumorigenicity by placental extracts.

Ki-67 expression predicts radiotherapy failure in early glottic cancer.

Silencing IDO in dendritic cells: A novel approach to enhance cancer immunotherapy in a murine breast cancer model.

Frequent mutations in TP53 and CDKN2A found by next-generation sequencing of head and neck cancer cell lines.

A Pilot Study Comparing HPV-Positive and HPV-Negative Head and Neck Squamous Cell Carcinomas by Whole Exome Sequencing.

Inhibition of BRCA2 and Thymidylate Synthase Creates Multidrug Sensitive Tumor Cells via the Induction of Combined "Complementary Lethality".

A case report and genetic characterization of a massive acinic cell carcinoma of the parotid with delayed distant metastases.

Does HPV type affect outcome in oropharyngeal cancer?

High frequency of activating PIK3CA mutations in human papillomavirus-positive oropharyngeal cancer.

Imaging tumor growth non-invasively using expression of MagA or modified ferritin subunits to augment intracellular contrast for repetitive MRI.

Metallothionein-I- and -II-deficient mice display increased susceptibility to cadmium-induced fetal growth restriction.

Vaccinia virus outperforms a panel of other poxviruses as a potent oncolytic agent for the control of head and neck squamous cell carcinoma cell lines.

Non-covalently functionalized single-walled carbon nanotube for topical siRNA delivery into melanoma.

Targeted siRNA silencing of indoleamine 2, 3-dioxygenase in antigen-presenting cells using mannose-conjugated liposomes: a novel strategy for treatment of melanoma.

Indoleamine 2,3-dioxygenase mediates immune-independent human tumor cell resistance to olaparib, gamma radiation, and cisplatin.

Intravenous ascorbic acid as an adjuvant to interleukin-2 immunotherapy.

BRCA2 inhibition enhances cisplatin-mediated alterations in tumor cell proliferation, metabolism, and metastasis.

Single-walled carbon nanotubes noncovalently functionalized with lipid modified polyethylenimine for siRNA delivery in vitro and in vivo.