Neil R. Cashman

Acidic pH and detergents enhance in vitro conversion of human brain PrPC to a PrPSc-like form.

Oxidation-induced misfolding and aggregation of superoxide dismutase and its implications for amyotrophic lateral sclerosis.

A letter from CMAJ's editorial board to the CMA.

Gabapentin therapy for amyotrophic lateral sclerosis: lack of improvement in neuronal integrity shown by MR spectroscopy.

Induced adaptive resistance to oxidative stress in the CNS: a discussion on possible mechanisms and their therapeutic potential.

A prion protein epitope selective for the pathologically misfolded conformation.

Intrathecal B-cell clonal expansion, an early sign of humoral immunity, in the cerebrospinal fluid of patients with clinically isolated syndrome suggestive of multiple sclerosis.

Monomeric Cu,Zn-superoxide dismutase is a common misfolding intermediate in the oxidation models of sporadic and familial amyotrophic lateral sclerosis.

Prion diseases--close to effective therapy?

Mitochondrial proteomic analysis of a cell line model of familial amyotrophic lateral sclerosis.

Post-poliomyelitis syndrome.

Progress in prion vaccines and immunotherapies.

Current and future molecular diagnostics for prion diseases.

Decreased cell surface prion protein in mouse models of prion disease.

An immunological epitope selective for pathological monomer-misfolded SOD1 in ALS.

Species barriers for chronic wasting disease by in vitro conversion of prion protein.

Selective association of misfolded ALS-linked mutant SOD1 with the cytoplasmic face of mitochondria.

Novel mutations in TARDBP (TDP-43) in patients with familial amyotrophic lateral sclerosis.

Immunological mimicry of PrPC-PrPSc interactions: antibody-induced PrP misfolding.

Prion protein expression and release by mast cells after activation.

Design and delivery of a cryptic PrP(C) epitope for induction of PrP(Sc)-specific antibody responses.

Electrostatics in the stability and misfolding of the prion protein: salt bridges, self energy, and solvation.

Immunotherapy for prion diseases: opportunities and obstacles.

Prion disease susceptibility is affected by beta-structure folding propensity and local side-chain interactions in PrP.

Preface. Prion research in perspective.

Toward a mechanism of prion misfolding and structural models of PrP(Sc): current knowledge and future directions.

Differential expression of c-Ret in motor neurons versus non-neuronal cells is linked to the pathogenesis of ALS.

A theory for the anisotropic and inhomogeneous dielectric properties of proteins.

Detection of prion protein in urine-derived injectable fertility products by a targeted proteomic approach.

An overlapping reading frame in the PRNP gene encodes a novel polypeptide distinct from the prion protein.

Relative and regional stabilities of the hamster, mouse, rabbit, and bovine prion proteins toward urea unfolding assessed by nuclear magnetic resonance and circular dichroism spectroscopies.

The prion protein binds thiamine.

Sterol regulatory element binding protein-1 (SREBP1) activation in motor neurons in excitotoxicity and amyotrophic lateral sclerosis (ALS): Indip, a potential therapeutic peptide.

Intermolecular transmission of superoxide dismutase 1 misfolding in living cells.

Diagnostic accuracy of cerebrospinal fluid protein markers for sporadic Creutzfeldt-Jakob disease in Canada: a 6-year prospective study.

Generalization of the prion hypothesis to other neurodegenerative diseases: an imperfect fit.

Aberrant localization of FUS and TDP43 is associated with misfolding of SOD1 in amyotrophic lateral sclerosis.

A special focus issue on the materials of Prion 2011 meeting in Montreal, Canada.

Nanopore analysis of wild-type and mutant prion protein (PrP(C)): single molecule discrimination and PrP(C) kinetics.

Binding of bovine T194A PrP(C) by PrP(Sc)-specific antibodies: potential implications for immunotherapy of familial prion diseases.

PrP(Sc)-specific antibodies do not induce prion disease or misfolding of PrP(C) in highly susceptible Tga20 mice.

The prion protein ligand, stress-inducible phosphoprotein 1, regulates amyloid-β oligomer toxicity.

The prion protein modulates A-type K+ currents mediated by Kv4.2 complexes through dipeptidyl aminopeptidase-like protein 6.

Prion-like activity of Cu/Zn superoxide dismutase: implications for amyotrophic lateral sclerosis.

Nanopore analysis reveals differences in structural stability of ovine PrP(C) proteins corresponding to scrapie susceptible (VRQ) and resistance (ARR) genotypes.

Interpretation of cerebrospinal fluid protein tests in the diagnosis of sporadic Creutzfeldt-Jakob disease: an evidence-based approach.

Development of a multivalent, PrP(Sc)-specific prion vaccine through rational optimization of three disease-specific epitopes.

Safety, specificity and immunogenicity of a PrP(Sc)-specific prion vaccine based on the YYR disease specific epitope.

Intercellular propagated misfolding of wild-type Cu/Zn superoxide dismutase occurs via exosome-dependent and -independent mechanisms.

Update on the provisional estimation of developing iatrogenic variant Creutzfeldt-Jakob disease from human islet cell transplantation procedures.

Intermediate CAG repeat expansion in the ATXN2 gene is a unique genetic risk factor for ALS--a systematic review and meta-analysis of observational studies.

A meta-analysis of observational studies of the association between chronic occupational exposure to lead and amyotrophic lateral sclerosis.

Exosome-dependent and independent mechanisms are involved in prion-like transmission of propagated Cu/Zn superoxide dismutase misfolding.

From molecule to molecule and cell to cell: Prion-like mechanisms in amyotrophic lateral sclerosis.