Johann Kern

The Dickkopf-homolog 3 is expressed in tumor endothelial cells and supports capillary formation.

Alternative splicing of vasohibin-1 generates an inhibitor of endothelial cell proliferation, migration, and capillary tube formation.

Quantification of circulating endothelial and progenitor cells: comparison of quantitative PCR and four-channel flow cytometry.

Vasohibin inhibits angiogenic sprouting in vitro and supports vascular maturation processes in vivo.

GRP-78 secreted by tumor cells blocks the antiangiogenic activity of bortezomib.

Increased Dkk3 protein expression in platelets and megakaryocytes of patients with myeloproliferative neoplasms.

Antimyeloma activity of the sesquiterpene lactone cnicin: impact on Pim-2 kinase as a novel therapeutic target.

Phosphodiesterase type 5 inhibition reverts prostate fibroblast-to-myofibroblast trans-differentiation.

5-Methoxyleoligin, a lignan from Edelweiss, stimulates CYP26B1-dependent angiogenesis in vitro and induces arteriogenesis in infarcted rat hearts in vivo.

Favorable prognosis of operable non-small cell lung cancer (NSCLC) patients harboring an increased expression of tumor endothelial markers (TEMs).

SOCS2 correlates with malignancy and exerts growth-promoting effects in prostate cancer.

Oncogenic functions of IGF1R and INSR in prostate cancer include enhanced tumor growth, cell migration and angiogenesis.

PIAS1 is a crucial factor for prostate cancer cell survival and a valid target in docetaxel resistant cells.

Marine compounds inhibit growth of multiple myeloma in vitro and in vivo.