L. James Lee

A packaging technique for polymer microfluidic platforms.

Design of a novel hydrogel-based intelligent system for controlled drug release.

Design of a compact disk-like microfluidic platform for enzyme-linked immunosorbent assay.

Fabrication of well-defined PLGA scaffolds using novel microembossing and carbon dioxide bonding.

Generating highly ordered DNA nanostrand arrays.

Self-folding of three-dimensional hydrogel microstructures.

Polymer nano-engineering for biomedical applications.

Surface modification for enhancing antibody binding on polymer-based microfluidic device for enzyme-linked immunosorbent assay.

Assembly of three-dimensional polymeric constructs containing cells/biomolecules using carbon dioxide.

Microfluidic enzyme-linked immunosorbent assay technology.

Dynamic assembly by electrokinetic microfluidics.

New valve and bonding designs for microfluidic biochips containing proteins.

Fabrication of particulate reservoir-containing, capsulelike, and self-folding polymer microstructures for drug delivery.

Hydrophilic surface modification of cyclic olefin copolymer microfluidic chips using sequential photografting.

Gene transfection of mammalian cells using membrane sandwich electroporation.

A novel Raji-Burkitt's lymphoma model for preclinical and mechanistic evaluation of CD52-targeted immunotherapeutic agents.

Packaging of microfluidic chips via interstitial bonding technique.

Flow-guided assembly processes.

Electrokinetics induced asymmetric transport in polymeric nanonozzles.

Cationic lipid-coated magnetic nanoparticles associated with transferrin for gene delivery.

A facile microfluidic method for production of liposomes.

Growth and alignment of polyaniline nanofibres with superhydrophobic, superhydrophilic and other properties.

A biodegradable, immunoprotective, dual nanoporous capsule for cell-based therapies.

Lenalidomide down-regulates the CD20 antigen and antagonizes direct and antibody-dependent cellular cytotoxicity of rituximab on primary chronic lymphocytic leukemia cells.

A novel liposomal formulation of flavopiridol.

Protein A-based antibody immobilization onto polymeric microdevices for enhanced sensitivity of enzyme-linked immunosorbent assay.

Transferrin receptor-targeted lipid nanoparticles for delivery of an antisense oligodeoxyribonucleotide against Bcl-2.

Transferrin receptor targeted lipopolyplexes for delivery of antisense oligonucleotide g3139 in a murine k562 xenograft model.

Targeted delivery systems for oligonucleotide therapeutics.

Bioassembly of three-dimensional embryonic stem cell-scaffold complexes using compressed gases.

Semicontinuous flow electroporation chip for high-throughput transfection on mammalian cells.

Preparation, characterization and pharmacokinetics of folate receptor-targeted liposomes for docetaxel delivery.

Coaxial electrohydrodynamic spraying: a novel one-step technique to prepare oligodeoxynucleotide encapsulated lipoplex nanoparticles.

Single-molecule DNA dynamics in tapered contraction-expansion microchannels under electrophoresis.

Delivery of polyethylenimine/DNA complexes assembled in a microfluidics device.

Specific antibody immobilization with biotin-poly(L-lysine)-g-poly(ethylene glycol) and protein A on microfluidic chips.

Design and testing of a microfluidic biochip for cytokine enzyme-linked immunosorbent assay.

Delivery of antisense oligodeoxyribonucleotide lipopolyplex nanoparticles assembled by microfluidic hydrodynamic focusing.

Efficient delivery of antisense oligodeoxyribonucleotide g3139 by human serum albumin-coated liposomes.

Coaxial electrohydrodynamic spraying of plasmid DNA/polyethylenimine (PEI) polyplexes for enhanced nonviral gene delivery.

Targeted delivery of antisense oligodeoxynucleotide by transferrin conjugated pH-sensitive lipopolyplex nanoparticles: a novel oligonucleotide-based therapeutic strategy in acute myeloid leukemia.

Microfluidic methods for production of liposomes.

Micronozzle array enhanced sandwich electroporation of embryonic stem cells.

Nanoimprinting using self-assembled ceramic nanoislands.

Disulfide-linked liposomes: effective delivery vehicle for Bcl-2 antisense oligodeoxyribonucleotide G3139.

Transferrin-conjugated lipid-coated PLGA nanoparticles for targeted delivery of aromatase inhibitor 7alpha-APTADD to breast cancer cells.

Lipid-coated nano-calcium-phosphate (LNCP) for gene delivery.

High throughput assembly of spatially controlled 3D cell clusters on a micro/nanoplatform.

Ultrasound-enhanced microfluidic synthesis of liposomes.

Targeted nanoparticles enhanced flow electroporation of antisense oligonucleotides in leukemia cells.

Large laterally ordered nanochannel arrays from DNA combing and imprinting.

Patterning nanowire and micro-nanoparticle array on micropillar-structured surface: Experiment and modeling.

Micropatterning and characterization of electrospun poly(ε-caprolactone)/gelatin nanofiber tissue scaffolds by femtosecond laser ablation for tissue engineering applications.

Formation and finite element analysis of tethered bilayer lipid structures.

Receptor-targeted nanocarriers for therapeutic delivery to cancer.

Use of a nanoporous biodegradable miniature device to regulate cytokine release for cancer treatment.

A covalently stabilized lipid-polycation-DNA (sLPD) vector for antisense oligonucleotide delivery.

Electroporation dependence on cell size: optical tweezers study.

Microfluidic assembly of lipid-based oligonucleotide nanoparticles.

Efficient down-regulation of CDK4 by novel lipid nanoparticle-mediated siRNA delivery.

MicroRNA delivery by cationic lipoplexes for lung cancer therapy.

Liposomes containing (-)-gossypol-enriched cottonseed oil suppress Bcl-2 and Bcl-xL expression in breast cancer cells.

Uptake and intracellular fate of multifunctional nanoparticles: a comparison between lipoplexes and polyplexes via quantum dot mediated Förster resonance energy transfer.

Nanochannel electroporation delivers precise amounts of biomolecules into living cells.

SPANosomes as Delivery Vehicles for Small Interfering RNA (siRNA).

Efficient siRNA Delivery Using a Polyamidoamine Dendrimer with a Modified Pentaerythritol Core.

Differential efficacy of DOTAP enantiomers for siRNA delivery in vitro.

Micro/nanoscale technologies for the development of hormone-expressing islet-like cell clusters.

The prolonged survival of fibroblasts with forced lipid catabolism in visceral fat following encapsulation in alginate-poly-L-lysine.

Novel lipoidal amine-based nanocarrier formulations for siRNA delivery.

Micropatterned thermoresponsive surfaces by polymerization of monomer crystals: modulating cellular morphology and cell-substrate interactions.

Lactosylated liposomes for targeted delivery of doxorubicin to hepatocellular carcinoma.

High-performance nanopapers based on benzenesulfonic functionalized graphenes.

Lenalidomide-mediated enhanced translation of C/EBPα-p30 protein up-regulates expression of the antileukemic microRNA-181a in acute myeloid leukemia.

Comparative cellular pharmacokinetics and pharmacodynamics of siRNA delivery by SPANosomes and by cationic liposomes.

Targeted nanoparticle delivery overcomes off-target immunostimulatory effects of oligonucleotides and improves therapeutic efficacy in chronic lymphocytic leukemia.

A naonoporous cell-therapy device with controllable biodegradation for long-term drug release.

Micro-/nanofluidics based cell electroporation.

Surface-mediated nucleic acid delivery by lipoplexes prepared in microwell arrays.

Therapeutic Delivery of MicroRNA-29b by Cationic Lipoplexes for Lung Cancer.

Targeted drug delivery and cross-linking induced apoptosis with anti-CD37 based dual-ligand immunoliposomes in B chronic lymphocytic leukemia cells.

Cationic lipid nanoparticles for therapeutic delivery of siRNA and miRNA to murine liver tumor.

Atomic carbide bonding leading to superior graphene networks.

Graphene-coated Si mold for precision glass optics molding.

A novel liposomal formulation of FTY720 (fingolimod) for promising enhanced targeted delivery.

Nonendocytic delivery of lipoplex nanoparticles into living cells using nanochannel electroporation.

Detection of extracellular RNAs in cancer and viral infection via tethered cationic lipoplex nanoparticles containing molecular beacons.

Enhanced hepatic delivery of siRNA and microRNA using oleic acid based lipid nanoparticle formulations.

Epigenetic regulation of connective tissue growth factor by MicroRNA-214 delivery in exosomes from mouse or human hepatic stellate cells.

Design of a microchannel-nanochannel-microchannel array based nanoelectroporation system for precise gene transfection.

Microwell array guided assembly of lipoplex nanoparticles containing siRNA.

Insight into mechanisms of cellular uptake of lipid nanoparticles and intracellular release of small RNAs.

Quantification of OSU-2S, a novel derivative of FTY720, in mouse plasma by liquid chromatography-tandem mass spectrometry.

A microfluidic method to synthesize transferrin-lipid nanoparticles loaded with siRNA LOR-1284 for therapy of acute myeloid leukemia.

Microwell array-mediated delivery of lipoplexes containing nucleic acids for enhanced therapeutic efficacy.

Targeted delivery of tumor suppressor microRNA-1 by transferrin-conjugated lipopolyplex nanoparticles to patient-derived glioblastoma stem cells.

Preparation and evaluation of a novel liposomal formulation of cisplatin.

Indole-3-carbinol inhibits tumorigenicity of hepatocellular carcinoma cells via suppression of microRNA-21 and upregulation of phosphatase and tensin homolog.

Magnetic Tweezers-Based 3D Microchannel Electroporation for High-Throughput Gene Transfection in Living Cells.

Effect of nonendocytic uptake of nanoparticles on human bronchial epithelial cells.

Selective targeting of alveolar type II respiratory epithelial cells by anti-surfactant protein-C antibody-conjugated lipoplexes.

CD33-Targeted Lipid Nanoparticles (aCD33LNs) for Therapeutic Delivery of GTI-2040 to Acute Myelogenous Leukemia.

ROR1-targeted delivery of OSU-2S, a nonimmunosuppressive FTY720 derivative, exerts potent cytotoxicity in mantle-cell lymphoma in vitro and in vivo.