Nikolas K. Haass

The role of altered cell-cell communication in melanoma progression.

Up-regulated expression of zonula occludens protein-1 in human melanoma associates with N-cadherin and contributes to invasion and adhesion.

Adhesion, migration and communication in melanocytes and melanoma.

Differential induction of connexins 26 and 30 in skin tumors and their adjacent epidermis.

Normal human melanocyte homeostasis as a paradigm for understanding melanoma.

Multiple signaling pathways must be targeted to overcome drug resistance in cell lines derived from melanoma metastases.

An organometallic protein kinase inhibitor pharmacologically activates p53 and induces apoptosis in human melanoma cells.

Expression of integrin alpha10 is induced in malignant melanoma.

The mitogen-activated protein/extracellular signal-regulated kinase kinase inhibitor AZD6244 (ARRY-142886) induces growth arrest in melanoma cells and tumor regression when combined with docetaxel.

Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity.

From Xiphophorus to melanoma--a tribute to Steven Kazianis (1966-2008).

Melanoma biomarkers: current status and utility in diagnosis, prognosis, and response to therapy.

Melanoma progression exhibits a significant impact on connexin expression patterns in the epidermal tumor microenvironment.

Genetics of basal cell carcinoma.

PLX4032, a potent inhibitor of the B-Raf V600E oncogene, selectively inhibits V600E-positive melanomas.

Multiple desmoplastic melanomas in Birt-Hogg-Dubé syndrome and a proposed signaling link between folliculin, the mTOR pathway, and melanoma susceptibility.

Evaluation of cell cycle arrest in estrogen responsive MCF-7 breast cancer cells: pitfalls of the MTS assay.

Meeting report from the 2011 International Melanoma Congress, Tampa, Florida.

Modulation of NOXA and MCL-1 as a strategy for sensitizing melanoma cells to the BH3-mimetic ABT-737.

The BH3-mimetic ABT-737 sensitizes human melanoma cells to apoptosis induced by selective BRAF inhibitors but does not reverse acquired resistance.

In vitro three-dimensional tumor microenvironment models for anticancer drug discovery.

DNA repair and cell cycle checkpoint defects as drivers and therapeutic targets in melanoma.

Melanoma's connections to the tumour microenvironment.

A novel class of anticancer compounds targets the actin cytoskeleton in tumor cells.

Targeting glutamine transport to suppress melanoma cell growth.

Targeting the intrinsic apoptosis pathway as a strategy for melanoma therapy.

Melanoma never says die.

Real-time cell cycle imaging during melanoma growth, invasion, and drug response.

Detection of primary melanoma in individuals at extreme high risk: a prospective 5-year follow-up study.

Friends or foes: IL-10 and TGF-β in melanoma.

Expression of Bcl-xL and Mcl-1 in the nonmelanoma skin cancers of renal transplant recipients.

Switching the sphingolipid rheostat in the treatment of diabetes and cancer comorbidity from a problem to an advantage.

Short-term suppression of A315T mutant human TDP-43 expression improves functional deficits in a novel inducible transgenic mouse model of FTLD-TDP and ALS.

Cell Cycle Phase-Specific Drug Resistance as an Escape Mechanism of Melanoma Cells.

microRNA-7-5p inhibits melanoma cell proliferation and metastasis by suppressing RelA/NF-κB.

Modeling Melanoma In Vitro and In Vivo.

Multimodal tumor suppression by miR-302 cluster in melanoma and colon cancer.

Genome-wide gain-of-function screen for genes that induce epithelial-to-mesenchymal transition in breast cancer.

Cell cycle-tailored targeting of metastatic melanoma: Challenges and opportunities.

NFIB Mediates BRN2 Driven Melanoma Cell Migration and Invasion Through Regulation of EZH2 and MITF.

Dendritic Mesoporous Silica Nanoparticles for pH-Stimuli-Responsive Drug Delivery of TNF-Alpha.

Targeting endothelin receptor signalling overcomes heterogeneity driven therapy failure.

Real-Time Cell Cycle Imaging in a 3D Cell Culture Model of Melanoma.

Acetylsalicylic Acid Governs the Effect of Sorafenib in -Mutant Cancers.

HDAC inhibitors restore BRAF-inhibitor sensitivity by altering PI3K and survival signalling in a subset of melanoma.

Endogenous Replication Stress Marks Melanomas Sensitive to CHEK1 Inhibitors .

Mathematical Models for Cell Migration with Real-Time Cell Cycle Dynamics.

Microenvironment-Driven Dynamic Heterogeneity and Phenotypic Plasticity as a Mechanism of Melanoma Therapy Resistance.

FGFR2-activating mutations disrupt cell polarity to potentiate migration and invasion in endometrial cancer cell models.

Induction of endoplasmic reticulum stress as a strategy for melanoma therapy: is there a future?

Dynamic tumor heterogeneity in melanoma therapy: how do we address this in a novel model system?

The Role of Melanoma Cell-Stroma Interaction in Cell Motility, Invasion, and Metastasis.

RAB27A promotes melanoma cell invasion and metastasis via regulation of pro-invasive exosomes.

Magnolol induces cell death through PI3K/Akt-mediated epigenetic modifications boosting treatment of BRAF- and NRAS-mutant melanoma.

BCL-XL and MCL-1 are the key BCL-2 family proteins in melanoma cell survival.

Combined use of subclinical hydroxyurea and CHK1 inhibitor effectively controls melanoma and lung cancer progression, with reduced normal tissue toxicity compared to gemcitabine.

Mathematical models incorporating a multi-stage cell cycle replicate normally-hidden inherent synchronization in cell proliferation.

Examining Go-or-Grow Using Fluorescent Cell-Cycle Indicators and Cell-Cycle-Inhibiting Drugs.

Abrogation of RAB27A expression transiently affects melanoma cell proliferation.

GGCX mutations in a patient with overlapping pseudoxanthoma elasticum/cutis laxa-like phenotype.

Editorial: Recent Developments in Therapies and Diagnostic Tools for Melanoma and Non-melanoma Skin Cancer.

Synchronized oscillations in growing cell populations are explained by demographic noise.

A novel mathematical model of heterogeneous cell proliferation.

Rapid initiation of cell cycle reentry processes protects neurons from amyloid-β toxicity.

Mathematical Model of Tumour Spheroid Experiments with Real-Time Cell Cycle Imaging.

Targeting Replication Stress Using CHK1 Inhibitor Promotes Innate and NKT Cell Immune Responses and Tumour Regression.

Fluorescence-Based Quantitative and Spatial Analysis of Tumour Spheroids: A Proposed Tool to Predict Patient-Specific Therapy Response.

Quantitative analysis of tumour spheroid structure.

Reciprocal Regulation of BRN2 and NOTCH1/2 Signaling Synergistically Drives Melanoma Cell Migration and Invasion.

PTEN: A novel target for vitamin D in melanoma.

Designing and interpreting 4D tumour spheroid experiments.

RAB27A-mediated melanoma exosomes: promoters of invasion and metastasis.

A stochastic mathematical model of 4D tumour spheroids with real-time fluorescent cell cycle labelling.

Persister state-directed transitioning and vulnerability in melanoma.