Jean-Pierre Gorvel

Activation of Rho and Rab GTPases dissociates Brucella abortus internalization from intracellular trafficking.

Survival of Tropheryma whipplei, the agent of Whipple's disease, requires phagosome acidification.

The cytoplasmic tail of invariant chain regulates endosome fusion and morphology.

Coxiella burnetii survival in THP-1 monocytes involves the impairment of phagosome maturation: IFN-gamma mediates its restoration and bacterial killing.

Brucella intracellular life: from invasion to intracellular replication.

Salmonella typhimurium SifA effector protein requires its membrane-anchoring C-terminal hexapeptide for its biological function.

Virulence factors of the human opportunistic pathogen Serratia marcescens identified by in vivo screening.

Brucella evades macrophage killing via VirB-dependent sustained interactions with the endoplasmic reticulum.

Organelle robbery: Brucella interactions with the endoplasmic reticulum.

Intracellular trafficking study of a RB51 B. abortus vaccinal strain isolated from cow milk.

Improved methods for producing outer membrane vesicles in Gram-negative bacteria.

Macropinocytosis of polyplexes and recycling of plasmid via the clathrin-dependent pathway impair the transfection efficiency of human hepatocarcinoma cells.

Link between impaired maturation of phagosomes and defective Coxiella burnetii killing in patients with chronic Q fever.

Brucella coopts the small GTPase Sar1 for intracellular replication.

Bacteria spurned by self-absorbed cells.

Brucella lipopolysaccharide acts as a virulence factor.

Intracellular trafficking of Parachlamydia acanthamoebae.

Bactericidal and antiendotoxic properties of short cationic peptides derived from a snake venom Lys49 phospholipase A2.

Proteome analysis of Rickettsia conorii by two-dimensional gel electrophoresis coupled with mass spectrometry.

Cyclic beta-1,2-glucan is a Brucella virulence factor required for intracellular survival.

Antimicrobial activity of myotoxic phospholipases A2 from crotalid snake venoms and synthetic peptide variants derived from their C-terminal region.

The intracellular fate of Salmonella depends on the recruitment of kinesin.

Identification and structural characterization of an unusual mycobacterial monomeromycolyl-diacylglycerol.

Molecular motors hijacking by intracellular pathogens.

Characterization of Brucella abortus lipopolysaccharide macrodomains as mega rafts.

Differential inductions of TNF-alpha and IGTP, IIGP by structurally diverse classic and non-classic lipopolysaccharides.

Rickettsia conorii and R. prowazekii proteome analysis by 2DE-MS: a step toward functional analysis of rickettsial genomes.

Pathogen-endoplasmic-reticulum interactions: in through the out door.

Identification of two putative rickettsial adhesins by proteomic analysis.

Synthesis of phosphatidylcholine, a typical eukaryotic phospholipid, is necessary for full virulence of the intracellular bacterial parasite Brucella abortus.

The Salmonella effector protein PipB2 is a linker for kinesin-1.

Mimivirus giant particles incorporate a large fraction of anonymous and unique gene products.

The translocated Salmonella effector proteins SseF and SseG interact and are required to establish an intracellular replication niche.

Microbiology. Bacterial bushwacking through a microtubule jungle.

Proteome analysis of Rickettsia felis highlights the expression profile of intracellular bacteria.

Virulence factors in brucellosis: implications for aetiopathogenesis and treatment.

Brucella control of dendritic cell maturation is dependent on the TIR-containing protein Btp1.

Nanobacteria are mineralo fetuin complexes.

Analysis of kinesin accumulation on Salmonella-containing vacuoles.

Brucellosis vaccines: assessment of Brucella melitensis lipopolysaccharide rough mutants defective in core and O-polysaccharide synthesis and export.

Brucella: a Mr "Hide" converted into Dr Jekyll.

Is Brucella an enteric pathogen?

The differential interaction of Brucella and ochrobactrum with innate immunity reveals traits related to the evolution of stealthy pathogens.

The glyceraldehyde-3-phosphate dehydrogenase and the small GTPase Rab 2 are crucial for Brucella replication.

Brucella abortus induces Irgm3 and Irga6 expression via type-I IFN by a MyD88-dependent pathway, without the requirement of TLR2, TLR4, TLR5 and TLR9.

Pathogenic bacteria and dead cells are internalized by a unique subset of Peyer's patch dendritic cells that express lysozyme.

Interaction between the SifA virulence factor and its host target SKIP is essential for Salmonella pathogenesis.

Bacterial manipulation of innate immunity to promote infection.

The Brucella abortus phosphoglycerate kinase mutant is highly attenuated and induces protection superior to that of vaccine strain 19 in immunocompromised and immunocompetent mice.

SKIP, the host target of the Salmonella virulence factor SifA, promotes kinesin-1-dependent vacuolar membrane exchanges.

Transcriptome analysis of the Brucella abortus BvrR/BvrS two-component regulatory system.

Helicobacter pylori impairs murine dendritic cell responses to infection.

Inactivation of formyltransferase (wbkC) gene generates a Brucella abortus rough strain that is attenuated in macrophages and in mice.

The virulence protein SopD2 regulates membrane dynamics of Salmonella-containing vacuoles.

Contrasting roles of macrophages and dendritic cells in controlling initial pulmonary Brucella infection.

Brucella abortus ornithine lipids are dispensable outer membrane components devoid of a marked pathogen-associated molecular pattern.

An evolutionary strategy for a stealthy intracellular Brucella pathogen.

Salmonella detoxifying enzymes are sufficient to cope with the host oxidative burst.

Identification of a Brucella spp. secreted effector specifically interacting with human small GTPase Rab2.

In search of Brucella abortus type IV secretion substrates: screening and identification of four proteins translocated into host cells through VirB system.

Peyer's patch dendritic cells sample antigens by extending dendrites through M cell-specific transcellular pores.

Internal affairs: investigating the Brucella intracellular lifestyle.

What have we learned from brucellosis in the mouse model?

The differential production of cytokines by human Langerhans cells and dermal CD14(+) DCs controls CTL priming.

The lipopolysaccharide core of Brucella abortus acts as a shield against innate immunity recognition.

Brucella β 1,2 cyclic glucan is an activator of human and mouse dendritic cells.

Small GTPases and Brucella entry into the endoplasmic reticulum.

Lipopolysaccharide as a target for brucellosis vaccine design.

Pathogenic brucellae replicate in human trophoblasts.

Brucella T4SS: the VIP pass inside host cells.

Brucella evasion of adaptive immunity.

Lipopolysaccharides with acylation defects potentiate TLR4 signaling and shape T cell responses.

Neutrophils exert a suppressive effect on Th1 responses to intracellular pathogen Brucella abortus.

BtpB, a novel Brucella TIR-containing effector protein with immune modulatory functions.

Bartonella and Brucella--weapons and strategies for stealth attack.

Human plasma cells express granzyme B.

In vivo identification and characterization of CD4⁺ cytotoxic T cells induced by virulent Brucella abortus infection.

A toxin-antitoxin module of Salmonella promotes virulence in mice.

"If you bring an alarm, we will destroy it," said Brucella to the host cell.

Intracellular bacteria interfere with dendritic cell functions: role of the type I interferon pathway.

Myeloid decidual dendritic cells and immunoregulation of pregnancy: defective responsiveness to Coxiella burnetii and Brucella abortus.

Brucella CβG induces a dual pro- and anti-inflammatory response leading to a transient neutrophil recruitment.

Escherichia coli α-hemolysin counteracts the anti-virulence innate immune response triggered by the Rho GTPase activating toxin CNF1 during bacteremia.

Cervical Lymph Nodes as a Selective Niche for Brucella during Oral Infections.

Innate and adaptive immune functions of peyer's patch monocyte-derived cells.

Brucella abortus Induces the Premature Death of Human Neutrophils through the Action of Its Lipopolysaccharide.

The Salmonella effector protein SifA plays a dual role in virulence.

RUN and FYVE domain-containing protein 4 enhances autophagy and lysosome tethering in response to Interleukin-4.

Subversion of mouse dendritic cell subset function by bacterial pathogens.

Gene expression profiling of the Peyer's patch mononuclear phagocyte system.

Brucella discriminates between mouse dendritic cell subsets upon in vitro infection.

Structural Studies of Lipopolysaccharide-defective Mutants from Brucella melitensis Identify a Core Oligosaccharide Critical in Virulence.

Effector proteins support the asymmetric apportioning of Salmonella during cytokinesis.

Functional Specialty of CD40 and Dendritic Cell Surface Lectins for Exogenous Antigen Presentation to CD8(+) and CD4(+) T Cells.