Shaun W. Lee

CD46 is phosphorylated at tyrosine 354 upon infection of epithelial cells by Neisseria gonorrhoeae.

PilT is required for PI(3,4,5)P3-mediated crosstalk between Neisseria gonorrhoeae and epithelial cells.

Monoclonal antibody detection of CD46 clustering beneath Neisseria gonorrhoeae microcolonies.

Dynamics of Neisseria gonorrhoeae attachment: microcolony development, cortical plaque formation, and cytoprotection.

Discovery of a widely distributed toxin biosynthetic gene cluster.

Structural and functional dissection of the heterocyclic peptide cytotoxin streptolysin S.

Clostridiolysin S, a post-translationally modified biotoxin from Clostridium botulinum.

An Escherichia coli-based bioengineering strategy to study streptolysin S biosynthesis.

Knowing is half the battle: targeting virulence factors of group A Streptococcus for vaccine and therapeutics.

Mutations in the control of virulence sensor gene from Streptococcus pyogenes after infection in mice lead to clonal bacterial variants with altered gene regulatory activity and virulence.

The wide world of ribosomally encoded bacterial peptides.

Unique genomic arrangements in an invasive serotype M23 strain of Streptococcus pyogenes identify genes that induce hypervirulence.

HIV protease inhibitors block streptolysin S production.

A multiparametric computational algorithm for comprehensive assessment of genetic mutations in mucopolysaccharidosis type IIIA (Sanfilippo syndrome).

Design and evaluation of a peptide-based immunotoxin for breast cancer therapeutics.

CovRS-Regulated Transcriptome Analysis of a Hypervirulent M23 Strain of Group A Streptococcus pyogenes Provides New Insights into Virulence Determinants.

Streptolysin S Promotes Programmed Cell Death and Enhances Inflammatory Signaling in Epithelial Keratinocytes during Group A Streptococcus Infection.

A large scale prediction of bacteriocin gene blocks suggests a wide functional spectrum for bacteriocins.

Streptococcus pyogenes Employs Strain-dependent Mechanisms of C3b Inactivation to Inhibit Phagocytosis and Killing of Bacteria.

Genomic Characterization of a Pattern D Streptococcus pyogenes emm53 Isolate Reveals a Genetic Rationale for Invasive Skin Tropicity.

Novel genomic rearrangements mediated by multiple genetic elements in Streptococcus pyogenes M23ND confer potentials for evolutionary persistence.