Joey P. Granger

84th President of APS Joey P. Granger.

Reduced endothelial NO-cGMP vascular relaxation pathway during TNF-alpha-induced hypertension in pregnant rats.

Tumor necrosis factor-alpha-induced hypertension in pregnant rats results in decreased renal neuronal nitric oxide synthase expression.

Low-salt diet enhances vascular reactivity and Ca(2+) entry in pregnant rats with normal and reduced uterine perfusion pressure.

Inducible nitric oxide synthase inhibition attenuates renal hemodynamics during pregnancy.

Mechanisms of pressure natriuresis.

Vascular mechanisms of increased arterial pressure in preeclampsia: lessons from animal models.

TNF-alpha enhances contraction and inhibits endothelial NO-cGMP relaxation in systemic vessels of pregnant rats.

Pathophysiology of preeclampsia: linking placental ischemia/hypoxia with microvascular dysfunction.

Enhanced thromboxane synthesis during chronic reductions in uterine perfusion pressure in pregnant rats.

Enhanced [Ca2+]i in renal arterial smooth muscle cells of pregnant rats with reduced uterine perfusion pressure.

Maternal and fetal adaptations during pregnancy: lessons in regulatory and integrative physiology.

Endothelin-induced increases in Ca2+ entry mechanisms of vascular contraction are enhanced during high-salt diet.

Evaluation of a rat model of preeclampsia for HELLP syndrome characteristics.

Endothelin.

Role of reactive oxygen species in endothelin-induced hypertension.

Cytochrome P-450 inhibition attenuates hypertension induced by reductions in uterine perfusion pressure in pregnant rats.

L-arginine attenuates hypertension in pregnant rats with reduced uterine perfusion pressure.

Inflammatory cytokines, vascular function, and hypertension.

Antisense oligodeoxynucleotides directed against a novel angiotensinogen mRNA-stabilizing protein reduce blood pressure in spontaneously hypertensive rats.

Role of endothelin in mediating tumor necrosis factor-induced hypertension in pregnant rats.

Hypertension produced by reductions in uterine perfusion in the pregnant rat: role of tumor necrosis factor-alpha.

Testosterone supplementation in aging men and women: possible impact on cardiovascular-renal disease.

Enhanced endothelin synthesis by endothelial cells exposed to sera from pregnant rats with decreased uterine perfusion.

An emerging role for inflammatory cytokines in hypertension.

Reduced uterine perfusion pressure (RUPP) model for studying cardiovascular-renal dysfunction in response to placental ischemia.

Endothelin, the kidney, and hypertension.

Hypertension produced by reductions in uterine perfusion in the pregnant rat: role of interleukin 6.

Hypertension produced by reduced uterine perfusion in pregnant rats is associated with increased soluble fms-like tyrosine kinase-1 expression.

Role of sex steroids in modulating tumor necrosis factor alpha-induced changes in vascular function and blood pressure.

Dietary salt enhances benzamil-sensitive component of myogenic constriction in mesenteric arteries.

Pathophysiology of hypertension during preeclampsia: linking placental ischemia with endothelial dysfunction.

ACE2 and ANG-(1-7) in the gravid uterus: the new players on the block.

Recent progress toward the understanding of the pathophysiology of hypertension during preeclampsia.

Hypertension and cardiovascular disease in women.

Inflammatory cytokines in the pathophysiology of hypertension during preeclampsia.

Pathophysiology of hypertension in response to placental ischemia during pregnancy: a central role for endothelin?

Role of reactive oxygen species in hypertension produced by reduced uterine perfusion in pregnant rats.

Autoantibodies to the angiotensin type I receptor in response to placental ischemia and tumor necrosis factor alpha in pregnant rats.

Hypertension in response to chronic reductions in uterine perfusion in pregnant rats: effect of tumor necrosis factor-alpha blockade.

Hypertension produced by placental ischemia in pregnant rats is associated with increased soluble endoglin expression.

Oxidative stress contributes to soluble fms-like tyrosine kinase-1 induced vascular dysfunction in pregnant rats.

Angiotensin II regulation of renal vascular ENaC proteins.

Inhibition of bilirubin metabolism induces moderate hyperbilirubinemia and attenuates ANG II-dependent hypertension in mice.

Effects of hyperhomocysteinemia on arterial pressure and nitric oxide production in pregnant rats.

Vascular endothelial growth factor inhibitors and hypertension: a central role for the kidney and endothelial factors?

17-Hydroxyprogesterone blunts the hypertensive response associated with reductions in uterine perfusion pressure in pregnant rats.

Effects of 17-hydroxyprogesterone on tumor necrosis factor-alpha-induced hypertension during pregnancy.

Recombinant vascular endothelial growth factor 121 infusion lowers blood pressure and improves renal function in rats with placentalischemia-induced hypertension.

Role of endothelin in mediating soluble fms-like tyrosine kinase 1-induced hypertension in pregnant rats.

The effect of immune factors, tumor necrosis factor-alpha, and agonistic autoantibodies to the angiotensin II type I receptor on soluble fms-like tyrosine-1 and soluble endoglin production in response to hypertension during pregnancy.

Role of reactive oxygen species during hypertension in response to chronic antiangiogenic factor (sFlt-1) excess in pregnant rats.

Regulation of sFlt-1 and VEGF secretion by adenosine under hypoxic conditions in rat placental villous explants.

Recent insights into the pathophysiology of preeclampsia.

Induction of heme oxygenase 1 attenuates placental ischemia-induced hypertension.

Endothelin type A receptor antagonist attenuates placental ischemia-induced hypertension and uterine vascular resistance.

Mechanisms and potential therapies for preeclampsia.

Changes in cardiac structure in hypertension produced by placental ischemia in pregnant rats: effect of tumor necrosis factor blockade.

Renal medullary endothelin-1 is decreased in Dahl salt-sensitive rats.

Endothelin: key mediator of hypertension in preeclampsia.

Induction of heme oxygenase-1 attenuates sFlt-1-induced hypertension in pregnant rats.

[The heart during pregnancy].

Role of 20-hydroxyeicosatetraenoic acid in mediating hypertension in response to chronic renal medullary endothelin type B receptor blockade.

Placental ischemia impairs middle cerebral artery myogenic responses in the pregnant rat.

L-arginine supplementation abolishes the blood pressure and endothelin response to chronic increases in plasma sFlt-1 in pregnant rats.

Physiologists without borders.

Heme Oxygenase-1 Attenuates Hypoxia-Induced sFlt-1 and Oxidative Stress in Placental Villi through Its Metabolic Products CO and Bilirubin.

Endothelin as a final common pathway in the pathophysiology of preeclampsia: therapeutic implications.

Bilirubin, renal hemodynamics, and blood pressure.

Linking placental ischemia and hypertension in preeclampsia: role of endothelin 1.

Control of soluble fms-like tyrosine-1 (sFlt-1) production response to placental ischemia/hypoxia: role of tumor necrosis factor-α.

Promoting physiology as an essential element in translational research.

Physiology's impact: discovering life.

Matrix metalloproteinases as drug targets in preeclampsia.

Heme oxygenase in pregnancy and preeclampsia.

Heme oxygenase inhibition increases blood pressure in pregnant rats.

Hypertension: physiology and pathophysiology.

Sildenafil attenuates placental ischemia-induced hypertension.

Recent advances in the understanding of the pathophysiology of preeclampsia.

Euglycemic hyperinsulinemia increases blood pressure in pregnant rats independent of placental antiangiogenic and inflammatory factors.

Obese melanocortin-4 receptor-deficient rats exhibit augmented angiogenic balance and vasorelaxation during pregnancy.

Heme oxygenase-1 promotes migration and β-epithelial Na+ channel expression in cytotrophoblasts and ischemic placentas.

Placental ischemia induces changes in gene expression in chorionic tissue.

The heme oxygenases: important regulators of pregnancy and preeclampsia.

Ouabain inhibits placental sFlt1 production by repressing HSP27-dependent HIF-1α pathway.

An unusual cause of mineralocorticoid hypertension.

Placental ischemia in pregnant rats impairs cerebral blood flow autoregulation and increases blood-brain barrier permeability.

Reduced uterine perfusion pressure induces hypertension in the pregnant mouse.

Roles for the sympathetic nervous system, renal nerves, and CNS melanocortin-4 receptor in the elevated blood pressure in hyperandrogenemic female rats.

Brain-mediated antidiabetic, anorexic, and cardiovascular actions of leptin require melanocortin-4 receptor signaling.

Chronic hyperleptinemia results in the development of hypertension in pregnant rats.

Emerging drugs for preeclampsia--the endothelium as a target.

Inhalation of carbon monoxide is ineffective as a long-term therapy to reduce obesity in mice fed a high fat diet.

Heme oxygenase induction attenuates TNF-α-induced hypertension in pregnant rodents.

Placental ischemia-induced increases in brain water content and cerebrovascular permeability: role of TNF-α.

Increased risk for the development of preeclampsia in obese pregnancies: weighing in on the mechanisms.

Immune Mechanisms Linking Obesity and Preeclampsia.

Preeclampsia and Pregnancy-Related Hypertensive Disorders.

Sildenafil Treatment Ameliorates the Maternal Syndrome of Preeclampsia and Rescues Fetal Growth in the Dahl Salt-Sensitive Rat.

Placental Growth Factor Administration Abolishes Placental Ischemia-Induced Hypertension.

Renal intramedullary infusion of tempol normalizes the blood pressure response to intrarenal blockade of heme oxygenase-1 in angiotensin II-dependent hypertension.

Differential body weight, blood pressure and placental inflammatory responses to normal versus high-fat diet in melanocortin-4 receptor-deficient pregnant rats.

Nitric oxide synthase-mediated blood pressure regulation in obese melanocortin-4 receptor-deficient pregnant rats.