Catherine Proenza

Identification of a region of RyR1 that participates in allosteric coupling with the alpha(1S) (Ca(V)1.1) II-III loop.

Pacemaker channels produce an instantaneous current.

Different roles for the cyclic nucleotide binding domain and amino terminus in assembly and expression of hyperpolarization-activated, cyclic nucleotide-gated channels.

Separable gating mechanisms in a Mammalian pacemaker channel.

A conserved domain in the NH2 terminus important for assembly and functional expression of pacemaker channels.

Inactivation in HCN channels results from reclosure of the activation gate: desensitization to voltage.

Distinct populations of HCN pacemaker channels produce voltage-dependent and voltage-independent currents.

Phosphorylation and modulation of hyperpolarization-activated HCN4 channels by protein kinase A in the mouse sinoatrial node.

Myristoylated peptides potentiate the funny current (I(f)) in sinoatrial myocytes.

Cellular context and multiple channel domains determine cAMP sensitivity of HCN4 channels: ligand-independent relief of autoinhibition in HCN4.

PKA-independent activation of I(f) by cAMP in mouse sinoatrial myocytes.

Complete atrial-specific knockout of sodium-calcium exchange eliminates sinoatrial node pacemaker activity.

Culture and adenoviral infection of sinoatrial node myocytes from adult mice.

High-efficiency reprogramming of fibroblasts into cardiomyocytes requires suppression of pro-fibrotic signalling.