Ching-Kang Chen

Evidence for two apoptotic pathways in light-induced retinal degeneration.

Recoverin and rhodopsin kinase.

Palmitoylation regulates regulators of G-protein signaling (RGS) 16 function. I. Mutation of amino-terminal cysteine residues on RGS16 prevents its targeting to lipid rafts and palmitoylation of an internal cysteine residue.

Instability of GGL domain-containing RGS proteins in mice lacking the G protein beta-subunit Gbeta5.

Light-dependent redistribution of visual arrestins and transducin subunits in mice with defective phototransduction.

RGS9 modulates dopamine signaling in the basal ganglia.

Retinal remodeling triggered by photoreceptor degenerations.

Prolonged photoresponses and defective adaptation in rods of Gbeta5-/- mice.

Photoreceptor cGMP phosphodiesterase delta subunit (PDEdelta) functions as a prenyl-binding protein.

Novel form of adaptation in mouse retinal rods speeds recovery of phototransduction.

The DEP domain determines subcellular targeting of the GTPase activating protein RGS9 in vivo.

Rhodopsin-iCre transgenic mouse line for Cre-mediated rod-specific gene targeting.

D2 dopamine receptors colocalize regulator of G-protein signaling 9-2 (RGS9-2) via the RGS9 DEP domain, and RGS9 knock-out mice develop dyskinesias associated with dopamine pathways.

Transducin activation state controls its light-dependent translocation in rod photoreceptors.

Deactivation of phosphorylated and nonphosphorylated rhodopsin by arrestin splice variants.

GAP-independent termination of photoreceptor light response by excess gamma subunit of the cGMP-phosphodiesterase.

Phototransduction in a transgenic mouse model of Nougaret night blindness.

RGS expression rate-limits recovery of rod photoresponses.

Transducin translocation in rods is triggered by saturation of the GTPase-activating complex.

Subunit dissociation and diffusion determine the subcellular localization of rod and cone transducins.

Sphingosine-1-phosphate and endothelin-1 induce the expression of rgs16 protein in cardiac myocytes by transcriptional activation of the rgs16 gene.

Expression and localization of RGS9-2/G 5/R7BP complex in vivo is set by dynamic control of its constitutive degradation by cellular cysteine proteases.

Gbeta5 is required for normal light responses and morphology of retinal ON-bipolar cells.

Molecular architecture of Galphao and the structural basis for RGS16-mediated deactivation.

Role of LPA4/p2y9/GPR23 in negative regulation of cell motility.

Functional redundancy of R7 RGS proteins in ON-bipolar cell dendrites.

Trafficking of membrane proteins to cone but not rod outer segments is dependent on heterotrimeric kinesin-II.

Background light produces a recoverin-dependent modulation of activated-rhodopsin lifetime in mouse rods.

Deletion of GRK1 causes retina degeneration through a transducin-independent mechanism.

The role of Gβ5 in vision.

RGS6, a modulator of parasympathetic activation in heart.

Rod outer segment retinol formation is independent of Abca4, arrestin, rhodopsin kinase, and rhodopsin palmitylation.

Nicotinic excitatory postsynaptic potentials in hippocampal CA1 interneurons are predominantly mediated by nicotinic receptors that contain α4 and β2 subunits.

Knockout of G protein β5 impairs brain development and causes multiple neurologic abnormalities in mice.

Modulation of CREB in the dorsal lateral geniculate nucleus of dark-reared mice.

Defective retinal depolarizing bipolar cells in regulators of G protein signaling (RGS) 7 and 11 double null mice.

The relationship between slow photoresponse recovery rate and temporal resolution of vision.

Modulation of mouse rod response decay by rhodopsin kinase and recoverin.

Role of ELOVL4 and very long-chain polyunsaturated fatty acids in mouse models of Stargardt type 3 retinal degeneration.

Light-induced translocation of RGS9-1 and Gβ5L in mouse rod photoreceptors.

Phosducin-like protein 1 is essential for G-protein assembly and signaling in retinal rod photoreceptors.

G protein beta 5 is targeted to D2-dopamine receptor-containing biochemical compartments and blocks dopamine-dependent receptor internalization.

Visual defects in a mouse model of fetal alcohol spectrum disorder.

Cannabinoid receptor-interacting protein 1a modulates CB1 receptor signaling and regulation.

Retinal cone photoreceptors require phosducin-like protein 1 for G protein complex assembly and signaling.

Rhodopsin kinase and recoverin modulate phosphodiesterase during mouse photoreceptor light adaptation.

RGS Protein Regulation of Phototransduction.

A Novel Retinal Oscillation Mechanism in an Autosomal Dominant Photoreceptor Degeneration Mouse Model.