Catherine M. Verfaillie

The Hematopoietic Microenvironment: Stromal Extracellular Matrix Components As Growth Regulators For Human Hematopoietic Progenitors.

Origin of endothelial progenitors in human postnatal bone marrow.

Methotrexate exacerbates tumor progression in a murine model of chronic myeloid leukemia.

Human bone marrow stem cells exhibit neural phenotypes and ameliorate neurological deficits after grafting into the ischemic brain of rats.

Hematopoietic stem cells for transplantation.

Multipotent adult progenitor cells from bone marrow differentiate into functional hepatocyte-like cells.

Myeloid-lymphoid initiating cells (ML-IC) are highly enriched in the rhodamine-c-kit(+)CD33(-)CD38(-) fraction of umbilical cord CD34(+) cells.

Pluripotency of mesenchymal stem cells derived from adult marrow.

Blockerette-ligated capture T7-amplified RT-PCR, a new method for determining flanking sequences.

Multipotent progenitor cells can be isolated from postnatal murine bone marrow, muscle, and brain.

Optimizing hematopoietic stem cell engraftment: a novel role for thrombopoietin.

Investigator profile. Interview by Vicki I. Glaser.

Adult stem cells: assessing the case for pluripotency.

Stem cells: hype and reality.

BCR/ABL: from molecular mechanisms of leukemia induction to treatment of chronic myelogenous leukemia.

Mechanisms underlying abnormal trafficking and expansion of malignant progenitors in CML: BCR/ABL-induced defects in integrin function in CML.

The microenvironment of AFT024 cells maintains primitive human hematopoiesis by counteracting contact mediated inhibition of proliferation.

Platelet factor 4 promotes adhesion of hematopoietic progenitor cells and binds IL-8: novel mechanisms for modulation of hematopoiesis.

BCR/ABL-mediated increased expression of multiple known and novel genes that may contribute to the pathogenesis of chronic myelogenous leukemia.

Identification of genes responsible for osteoblast differentiation from human mesodermal progenitor cells.

Spontaneous circulation of myeloid-lymphoid-initiating cells and SCID-repopulating cells in sickle cell crisis.

Trimetrexate inhibits progression of the murine 32Dp210 model of chronic myeloid leukemia in animals expressing drug-resistant dihydrofolate reductase.

Immunohistochemical identification of multipotent adult progenitor cells from human bone marrow after transplantation into the rat brain.

Neural differentiation and incorporation of bone marrow-derived multipotent adult progenitor cells after single cell transplantation into blastocyst stage mouse embryos.

Neuroectodermal differentiation from mouse multipotent adult progenitor cells.

Statistical significance analysis of longitudinal gene expression data.

Safety issues in cell-based intervention trials.

Public stem cell banks: considerations of justice in stem cell research and therapy.

Integrin engagement-induced inhibition of human myelopoiesis is mediated by proline-rich tyrosine kinase 2 gene products.

Ex vivo expansion of umbilical cord blood hemopoietic stem and progenitor cells.

Efficient transfection of embryonic and adult stem cells.

Transplantation of 2 partially HLA-matched umbilical cord blood units to enhance engraftment in adults with hematologic malignancy.

Phosphatidylinositol-3-kinase activation mediates proline-rich tyrosine kinase 2 phosphorylation and recruitment to beta1-integrins in human CD34+ cells.

Distinct genomic integration of MLV and SIV vectors in primate hematopoietic stem and progenitor cells.

Characterization of expanded intermediate cell mass in zebrafish chordin morphant embryos.

A multifactorial analysis of umbilical cord blood, adult bone marrow and mobilized peripheral blood progenitors using the improved ML-IC assay.

All-trans retinoic acid (ATRA) enhances maintenance of primitive human hematopoietic progenitors and skews them towards myeloid differentiation in a stroma-noncontact culture system.

Real-time in vivo imaging of stem cells following transgenesis by transposition.

Laser-guided direct writing for three-dimensional tissue engineering.

Multipotent adult progenitor cells: an update.

Functional analysis of human hematopoietic stem cell gene expression using zebrafish.

The molecular repertoire of the 'almighty' stem cell.

Neural induction of adult bone marrow and umbilical cord stem cells.

Culture systems for pluripotent stem cells.

Thymidine analogs are transferred from prelabeled donor to host cells in the central nervous system after transplantation: a word of caution.

Host factors that impact the biodistribution and persistence of multipotent adult progenitor cells.

Regulation of primitive hematopoiesis in zebrafish embryos by the death receptor gene.

Defined conditions for development of functional hepatic cells from human embryonic stem cells.

Placental growth factor mediates mesenchymal cell development, cartilage turnover, and bone remodeling during fracture repair.

Endothelium-mediated hepatocyte recruitment in the establishment of liver-like tissue in vitro.

7. Transplantation of undifferentiated, bone marrow-derived stem cells.

In vitro and in vivo arterial differentiation of human multipotent adult progenitor cells.

The transcription factors Scl and Lmo2 act together during development of the hemangioblast in zebrafish.

Cytokine-induced differentiation of multipotent adult progenitor cells into functional smooth muscle cells.

Islet-derived fibroblast-like cells are not derived via epithelial-mesenchymal transition from Pdx-1 or insulin-positive cells.

Pluripotency in adult stem cells: state of the art.

Multipotent adult progenitor cell and stem cell plasticity.

All-trans retinoic acid induces proliferation of an irradiated stem cell supporting stromal cell line AFT024.

Genome-wide reverse genetics framework to identify novel functions of the vertebrate secretome.

Hematopoietic reconstitution by multipotent adult progenitor cells: precursors to long-term hematopoietic stem cells.

Plasticity and cardiovascular applications of multipotent adult progenitor cells.

Evaluation of neural plasticity in adult stem cells.

Biology of umbilical cord blood progenitors in bone marrow niches.

Bioenergetic and functional consequences of bone marrow-derived multipotent progenitor cell transplantation in hearts with postinfarction left ventricular remodeling.

The role of survivin in angiogenesis during zebrafish embryonic development.

Comparative transcriptome analysis of embryonic and adult stem cells with extended and limited differentiation capacity.

Therapeutic potential of adult progenitor cells in cardiovascular disease.

Multipotent adult progenitor cell transplantation increases vascularity and improves left ventricular function after myocardial infarction.

Multipotent adult progenitor cells sustain function of ischemic limbs in mice.

Isolation and characterization of a novel population of progenitor cells from unmanipulated rat liver.

Self-renewal and differentiation capacity of young and aged stem cells.

Nitric oxide enhances Oct-4 expression in bone marrow stem cells and promotes endothelial differentiation.

Bone-marrow-derived cells and heart repair.

Emerging hurdles in stem cell therapy for peripheral vascular disease.

Bony endothelium: tumor-mediated transdifferentiation?

High glucose attenuates VEGF expression in rat multipotent adult progenitor cells in association with inhibition of JAK2/STAT3 signalling.

Directed differentiation of mouse cochlear neural progenitors in vitro.

Adult stem and progenitor cells.

Stem cells for ischemic brain injury: a critical review.

Mouse MAPC-mediated immunomodulation: Cell-line dependent variation.

Ox-LDL modifies the behaviour of bone marrow stem cells and impairs their endothelial differentiation via inhibition of Akt phosphorylation.

Transforming Growth Factor type beta and Smad family signaling in stem cell function.

Isolation procedure and characterization of multipotent adult progenitor cells from rat bone marrow.

Effects of MRI contrast agents on the stem cell phenotype.

Cardiomyocyte differentiation of rat bone marrow multipotent progenitor cells is associated with downregulation of Oct-4 expression.

Increased beta-cell mass by islet transplantation and PLAG1 overexpression causes hyperinsulinemic normoglycemia and hepatic insulin resistance in mice.

Human embryonic and rat adult stem cells with primitive endoderm-like phenotype can be fated to definitive endoderm, and finally hepatocyte-like cells.

Reactive oxygen species mediate oxidized low-density lipoprotein-induced inhibition of oct-4 expression and endothelial differentiation of bone marrow stem cells.

Maintenance of HSC by Wnt5a secreting AGM-derived stromal cell line.

Deficiency of either P-glycoprotein or breast cancer resistance protein protect against acute kidney injury.

A scalable approach for discovering conserved active subnetworks across species.

Pdx1- and Ngn3-Cre-mediated PLAG1 expression in the pancreas leads to endocrine hormone imbalances that affect glucose metabolism.

Concise review: culture mediated changes in fate and/or potency of stem cells.

Oct4-negative multipotent adult progenitor cells and mesenchymal stem cells as regulators of T-cell alloreactivity in mice.

Multipotent adult progenitor cells.

Differentiation potential of human postnatal mesenchymal stem cells, mesoangioblasts, and multipotent adult progenitor cells reflected in their transcriptome and partially influenced by the culture conditions.

Induction of a mature hepatocyte phenotype in adult liver derived progenitor cells by ectopic expression of transcription factors.

Enhanced differentiation of adult bone marrow-derived stem cells to liver lineage in aggregate culture.

Culture of mouse embryonic stem cells with serum but without exogenous growth factors is sufficient to generate functional hepatocyte-like cells.

Efficient non-viral integration and stable gene expression in multipotent adult progenitor cells.

Hurler disease bone marrow stromal cells exhibit altered ability to support osteoclast formation.

High glucose enhances TGF-β1 expression in rat bone marrow stem cells via ERK1/2-mediated inhibition of STAT3 signaling.

Zic3 induces conversion of human fibroblasts to stable neural progenitor-like cells.

Human pluripotent stem cell-derived hepatocytes support complete replication of hepatitis C virus.

High glucose facilitates cell cycle arrest of rat bone marrow multipotent adult progenitor cells through transforming growth factor-β1 and extracellular signal-regulated kinase 1/2 signalling without changing Oct4 expression.

Cryopreserved reticulocytes derived from hematopoietic stem cells can be invaded by cryopreserved Plasmodium vivax isolates.

MAPC culture conditions support the derivation of cells with nascent hypoblast features from bone marrow and blastocysts.

Antagonism of Nodal signaling by BMP/Smad5 prevents ectopic primitive streak formation in the mouse amnion.

Human multipotent adult progenitor cells are nonimmunogenic and exert potent immunomodulatory effects on alloreactive T-cell responses.

TGFβ1-induced Baf60c regulates both smooth muscle cell commitment and quiescence.

Hematopoietic stem/progenitor cell proliferation and differentiation is differentially regulated by high-density and low-density lipoproteins in mice.

Concise review: Bone marrow meets blastocyst: lessons from an unlikely encounter.

Neural differentiation and support of neuroregeneration of non-neural adult stem cells.

A novel role of BMP4 in adult hematopoietic stem and progenitor cell homing via Smad independent regulation of integrin-α4 expression.

NKX2-1 activation by SMAD2 signaling after definitive endoderm differentiation in human embryonic stem cell.

Immunological characteristics of human mesenchymal stem cells and multipotent adult progenitor cells.

Glypican-3-mediated inhibition of CD26 by TFPI: a novel mechanism in hematopoietic stem cell homing and maintenance.

Wnt5a does not support hematopoiesis in stroma-free, serum-free cultures.

COUP-TFII orchestrates venous and lymphatic endothelial identity by homo- or hetero-dimerisation with PROX1.

18F-FDG labeling of mesenchymal stem cells and multipotent adult progenitor cells for PET imaging: effects on ultrastructure and differentiation capacity.

Zic3 enhances the generation of mouse induced pluripotent stem cells.

Self-renewal of neural stem cells: implications for future therapies.

Mutual interaction between human multipotent adult progenitor cells and NK cells.

Reversal of hyperglycemia by insulin-secreting rat bone marrow- and blastocyst-derived hypoblast stem cell-like cells.

Stem cells and liver engineering.

Spheroid culture for enhanced differentiation of human embryonic stem cells to hepatocyte-like cells.

The road to regenerative liver therapies: the triumphs, trials and tribulations.

Mesenchymal stem cells migration homing and tracking.

Variability in contrast agent uptake by different but similar stem cell types.

Biliary cells to the rescue of Prometheus.

Hepatic differentiation of human embryonic stem cells on microcarriers.

Prospectively isolated NGN3-expressing progenitors from human embryonic stem cells give rise to pancreatic endocrine cells.

MicroRNAs: the fine modulators of liver development and function.

Optimization of multimodal imaging of mesenchymal stem cells using the human sodium iodide symporter for PET and Cerenkov luminescence imaging.

Comparisons of phenotype and immunomodulatory capacity among rhesus bone-marrow-derived mesenchymal stem/stromal cells, multipotent adult progenitor cells, and dermal fibroblasts.

Regulation of high-density lipoprotein on hematopoietic stem/progenitor cells in atherosclerosis requires scavenger receptor type BI expression.

Hydrogen peroxide inhibits proliferation and endothelial differentiation of bone marrow stem cells partially via reactive oxygen species generation.

SMAD signaling regulates CXCL12 expression in the bone marrow niche, affecting homing and mobilization of hematopoietic progenitors.

FANCA knockout in human embryonic stem cells causes a severe growth disadvantage.

Controlling and monitoring stem cell safety in vivo in an experimental rodent model.

Cell membrane damage is involved in the impaired survival of bone marrow stem cells by oxidized low-density lipoprotein.

Hematopoietic stem/progenitor cell sources to generate reticulocytes for Plasmodium vivax culture.

Radiolabeling strategies for radionuclide imaging of stem cells.

Hematopoietic stem/progenitor cells directly contribute to arteriosclerotic progression via integrin β2.

Restoration of progranulin expression rescues cortical neuron generation in an induced pluripotent stem cell model of frontotemporal dementia.

From mice to mind: Strategies and progress in translating neuroregeneration.

Stem Cell-Derived Oligodendroglial Cells for Therapy in Neurological Diseases.

Assessment of bystander killing-mediated therapy of malignant brain tumors using a multimodal imaging approach.

Efficient Recombinase-Mediated Cassette Exchange in hPSCs to Study the Hepatocyte Lineage Reveals AAVS1 Locus-Mediated Transgene Inhibition.

Mesodermal iPSC-derived progenitor cells functionally regenerate cardiac and skeletal muscle.

Highly proliferative primitive fetal liver hematopoietic stem cells are fueled by oxidative metabolic pathways.

Sodium Iodide Symporter PET and BLI Noninvasively Reveal Mesoangioblast Survival in Dystrophic Mice.

Stem cell-derived hepatocytes: A novel model for hepatitis E virus replication.

Monitoring the Bystander Killing Effect of Human Multipotent Stem Cells for Treatment of Malignant Brain Tumors.

Increased Understanding of Stem Cell Behavior in Neurodegenerative and Neuromuscular Disorders by Use of Noninvasive Cell Imaging.

Epigenetic Induction of Definitive and Pancreatic Endoderm Cell Fate in Human Fibroblasts.

Clinical-Grade Human Multipotent Adult Progenitor Cells Block CD8+ Cytotoxic T Lymphocytes.

H3K27me3 Does Not Orchestrate the Expression of Lineage-Specific Markers in hESC-Derived Hepatocytes In Vitro.

Correction: Origin of endothelial progenitors in human postnatal bone marrow