Craig E. Wheelock

Structural refinement of inhibitors of urea-based soluble epoxide hydrolases.

Use of ab initio calculations to predict the biological potency of carboxylesterase inhibitors.

Joint acute toxicity of esfenvalerate and diazinon to larval fathead minnows (Pimephales promelas).

Evaluation of alpha-cyanoesters as fluorescent substrates for examining interindividual variation in general and pyrethroid-selective esterases in human liver microsomes.

Juvenile hormone (JH) esterase: why are you so JH specific?

Use of classical and 3-D QSAR to examine the hydration state of juvenile hormone esterase inhibitors.

Pyrethroid tolerance in Culex pipiens pipiens var molestus from Marin County, California.

Identification, expression, and purification of a pyrethroid-hydrolyzing carboxylesterase from mouse liver microsomes.

Investigation of the role of a second conserved serine in carboxylesterases via site-directed mutagenesis.

Development of toxicity identification evaluation procedures for pyrethroid detection using esterase activity.

A new class of inhibitors of 2-arachidonoylglycerol hydrolysis and invasion of prostate cancer cells.

Influence of container adsorption upon observed pyrethroid toxicity to Ceriodaphnia dubia and Hyalella azteca.

Individual variability in esterase activity and CYP1A levels in Chinook salmon (Oncorhynchus tshawytscha) exposed to esfenvalerate and chlorpyrifos.

Evaluation of alpha-cyano ethers as fluorescent substrates for assay of cytochrome P450 enzyme activity.

High-throughput screening of ecdysone agonists using a reporter gene assay followed by 3-D QSAR analysis of the molting hormonal activity.

Structural studies of a potent insect maturation inhibitor bound to the juvenile hormone esterase of Manduca sexta.

Use of carboxylesterase activity to remove pyrethroid-associated toxicity to Ceriodaphnia dubia and Hyalella azteca in toxicity identification evaluations.

Analysis of mammalian carboxylesterase inhibition by trifluoromethylketone-containing compounds.

Diverse roles of 2-arachidonoylglycerol in invasion of prostate carcinoma cells: Location, hydrolysis and 12-lipoxygenase metabolism.

PfEMP1-DBL1alpha amino acid motifs in severe disease states of Plasmodium falciparum malaria.

Influence of sulfur oxidation state and steric bulk upon trifluoromethyl ketone (TFK) binding kinetics to carboxylesterases and fatty acid amide hydrolase (FAAH).

Identification of endocrine disruptor biodegradation by integration of structure-activity relationship with pathway analysis.

Effects of pyridine exposure upon structural lipid metabolism in Swiss Webster mice.

Development of metabolically stable inhibitors of Mammalian microsomal epoxide hydrolase.

Applications of carboxylesterase activity in environmental monitoring and toxicity identification evaluations (TIEs).

Tissue distribution, isozyme abundance and sensitivity to chlorpyrifos-oxon of carboxylesterases in the earthworm Lumbricus terrestris.

varDB: a pathogen-specific sequence database of protein families involved in antigenic variation.

From Genome to Proteome: Integration and proteome completion - 8th Siena Meeting.

Comparison of benzil and trifluoromethyl ketone (TFK)-mediated carboxylesterase inhibition using classical and 3D-quantitative structure-activity relationship analysis.

Clofibrate-induced changes in the liver, heart, brain and white adipose lipid metabolome of Swiss-Webster mice.

GeneRegionScan: a Bioconductor package for probe-level analysis of specific, small regions of the genome.

Systems biology approaches and pathway tools for investigating cardiovascular disease.

varDB: a database of antigenic variant sequences--current status and future prospects.

HPLC/MS/MS-based approaches for detection and quantification of eicosanoids.

Bioinformatics strategies for the analysis of lipids.

The use of network analyses for elucidating mechanisms in cardiovascular disease.

Tools for investigating mechanisms of antigenic variation: new extensions to varDB.

Advances in eicosanoid research, novel therapeutic implications.

Exosomes from human macrophages and dendritic cells contain enzymes for leukotriene biosynthesis and promote granulocyte migration.

12- and 15-lipoxygenases in human carotid atherosclerotic lesions: associations with cerebrovascular symptoms.

Lipid mediator profiling in pulmonary disease.

Asthmatics exhibit altered oxylipin profiles compared to healthy individuals after subway air exposure.

Phylogenetic analysis of lipid mediator GPCRs.

Allergic asthmatics show divergent lipid mediator profiles from healthy controls both at baseline and following birch pollen provocation.

Network analysis identifies a putative role for the PPAR and type 1 interferon pathways in glucocorticoid actions in asthmatics.

Building multivariate systems biology models.

Lipid mediator metabolic profiling demonstrates differences in eicosanoid patterns in two phenotypically distinct mast cell populations.

Application of metabolomics approaches to the study of respiratory diseases.

Application of 'omics technologies to biomarker discovery in inflammatory lung diseases.

Lipid mediator serum profiles in asthmatics significantly shift following dietary supplementation with omega-3 fatty acids.

Quantitative metabolic profiling of lipid mediators.

Quantification of lipid mediator metabolites in human urine from asthma patients by electrospray ionization mass spectrometry: controlling matrix effects.

Dendritic cell reprogramming by endogenously produced lactic acid.

Trials and tribulations of 'omics data analysis: assessing quality of SIMCA-based multivariate models using examples from pulmonary medicine.

Lipid mediator profiles differ between lung compartments in asthmatic and healthy humans.

Effects of selective COX-2 inhibition on allergen-induced bronchoconstriction and airway inflammation in asthma.

Dietary nitrate reduces resting metabolic rate: a randomized, crossover study in humans.

Cord blood mesenchymal stem cells suppress DC-T Cell proliferation via prostaglandin B2.

Network analysis in the investigation of chronic respiratory diseases. From basics to application.

The effect of omega-3 fatty acids on bronchial hyperresponsiveness, sputum eosinophilia, and mast cell mediators in asthma.

LC-MS metabolomics of psoriasis patients reveals disease severity-dependent increases in circulating amino acids that are ameliorated by anti-TNFα treatment.

Hexosylceramides as intrathecal markers of worsening disability in multiple sclerosis.

High-dose simvastatin exhibits enhanced lipid-lowering effects relative to simvastatin/ezetimibe combination therapy.

Effects of long-term dietary nitrate supplementation in mice.

Urinary excretion of lipid mediators in response to repeated eucapnic voluntary hyperpnea in asthmatic subjects.

Circulating levels of sphingosine-1-phosphate are elevated in severe, but not mild psoriasis and are unresponsive to anti-TNF-α treatment.

Peri-ovulatory endocrine regulation of the prostanoid pathways in the bovine uterus at early dioestrus.

Lipid mediator profile in vernix caseosa reflects skin barrier development.

Activated prostaglandin D2 receptors on macrophages enhance neutrophil recruitment into the lung.

Metabolite Profiling and Stable Isotope Tracing in Sorted Subpopulations of Mammalian Cells.

Linoleic acid-derived lipid mediators increase in a female-dominated subphenotype of COPD.

Peritoneal dialysis impairs nitric oxide homeostasis and may predispose infants with low systolic blood pressure to cerebral ischemia.

Arginase Inhibition Improves Microvascular Endothelial Function in Patients With Type 2 Diabetes Mellitus.

Genetic Abrogation of Adenosine A3 Receptor Prevents Uninephrectomy and High Salt-Induced Hypertension.

Dietary nitrate improves age-related hypertension and metabolic abnormalities in rats via modulation of angiotensin II receptor signaling and inhibition of superoxide generation.

Innate Invariant NKT Cell Recognition of HIV-1-Infected Dendritic Cells Is an Early Detection Mechanism Targeted by Viral Immune Evasion.

New insights into the effects of onion consumption on lipid mediators using a diet-induced model of hypercholesterolemia.

Aspirin-triggered lipoxin inhibits atherosclerosis progression in ApoE(-/-) mice.