Department of Intensive Care Medicine
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Resuscitation from septic shock with capillary leakage: hydroxyethyl starch (130 kd), but not Ringer's solution maintains plasma volume and systemic oxygenation.
Shock (Augusta, Ga.) Apr, 2004 | Pubmed ID: 15179134
Activated protein C induces the release of microparticle-associated endothelial protein C receptor.
Blood Feb, 2005 | Pubmed ID: 15486064
Blood volume measurements using an integrated fiberoptic monitoring system in a porcine septic shock model.
Critical care medicine May, 2006 | Pubmed ID: 16557156
Venous oximetry.
Current opinion in critical care Jun, 2006 | Pubmed ID: 16672787
Correlation of oxygen delivery with central venous oxygen saturation, mean arterial pressure and heart rate in piglets.
Paediatric anaesthesia Sep, 2006 | Pubmed ID: 16918656
Attenuation of capillary leakage by hydroxyethyl starch (130/0.42) in a porcine model of septic shock.
Critical care medicine Dec, 2006 | Pubmed ID: 16971858
[Intensive insulin therapy in critically ill patients--contra].
Deutsche medizinische Wochenschrift (1946) Nov, 2006 | Pubmed ID: 17066360
Continuous monitoring of central venous oxygen saturation in neonates and small infants: in vitro evaluation of two different oximetry catheters.
Paediatric anaesthesia Dec, 2006 | Pubmed ID: 17121556
Hemodynamic changes during acute elevation of intra-abdominal pressure in rabbits.
Paediatric anaesthesia Dec, 2006 | Pubmed ID: 17121557
Hydrocortisone does not affect major platelet receptors in inflammation in vitro.
Steroids Jun, 2007 | Pubmed ID: 17509634
Time out for vasopressors in increased microvascular permeability?
Intensive care medicine Dec, 2007 | Pubmed ID: 17622513
Effect of Drotrecogin alfa (activated) on platelet receptor expression in vitro.
Platelets Aug, 2007 | Pubmed ID: 17654307
Dextran-70 to modulate inflammatory response after cardiopulmonary bypass: potential for a novel approach?
Critical care (London, England) , 2007 | Pubmed ID: 17850682
Successful treatment of an aggressive non-Hodgkin's lymphoma associated with acute respiratory insufficiency using extracorporeal membrane oxygenation.
Interactive cardiovascular and thoracic surgery Feb, 2008 | Pubmed ID: 18045830
The value of rotation thromboelastometry to monitor disturbed perioperative haemostasis and bleeding risk in patients with cardiopulmonary bypass.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis Apr, 2008 | Pubmed ID: 18388501
Endotoxaemia leads to major increases in inflammatory adipokine gene expression in white adipose tissue of mice.
Pflugers Archiv : European journal of physiology Feb, 2009 | Pubmed ID: 18677510
Correlations between platelet-derived microvesicles and thrombin generation in patients with coronary artery disease.
Platelets Sep, 2008 | Pubmed ID: 18925517
Acute short-term hyperglycemia impairs platelet receptor expression even in healthy adults in vitro.
Medical science monitor : international medical journal of experimental and clinical research Dec, 2008 | Pubmed ID: 19043364
Costs of intermittent measurement of central venous oxygen saturations by blood gas analysis.
Intensive care medicine Jul, 2009 | Pubmed ID: 19165462
Hydroxyethylstarch impairs renal function and induces interstitial proliferation, macrophage infiltration and tubular damage in an isolated renal perfusion model.
Critical care (London, England) , 2009 | Pubmed ID: 19239718
Minimally invasive haemodynamic monitoring.
European journal of anaesthesiology Dec, 2009 | Pubmed ID: 19916204
Characterization of buccal microvascular response in patients with septic shock.
European journal of anaesthesiology Apr, 2010 | Pubmed ID: 20090537
Fluid-induced coagulopathy: does the type of fluid make a difference?
Critical care (London, England) , 2010 | Pubmed ID: 20236489
In vivo microscopy in a porcine model of acute lung injury.
Respiratory physiology & neurobiology Jul, 2010 | Pubmed ID: 20638978
[Therapy for sepsis -- Quo vadis?].
Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS Sep, 2010 | Pubmed ID: 20839145
[Update and controversies of adjunctive sepsis therapy].
Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS Sep, 2010 | Pubmed ID: 20839148
Semi-fluorinated alkanes as carriers for drug targeting in acute respiratory failure.
Experimental lung research Oct, 2010 | Pubmed ID: 20939753
ADAMTS13 activity is decreased in a septic porcine model. Significance for glomerular thrombus deposition.
Thrombosis and haemostasis Jan, 2011 | Pubmed ID: 21057705
[Point-of-Care-Monitoring: Blood gas analysis].
Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS Nov, 2010 | Pubmed ID: 21125528
Arterial pressure-based cardiac output monitoring: a multicenter validation of the third-generation software in septic patients.
Intensive care medicine Feb, 2011 | Pubmed ID: 21153399
The intraoperative decrease of selenium is associated with the postoperative development of multiorgan dysfunction in cardiac surgical patients.
Critical care medicine Aug, 2011 | Pubmed ID: 21460705
[Heart failure - therapy with mechanical circulatory support: status quo and perspectives].
Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS Jun, 2011 | Pubmed ID: 21688230
Neurological outcome after experimental lung injury.
Respiratory physiology & neurobiology Dec, 2011 | Pubmed ID: 21855657
Impact of stable PGI₂ analog iloprost on early graft viability after liver transplantation: a pilot study.
Clinical transplantation Jan-Feb, 2012 | Pubmed ID: 21919966
Impairment of renal function using hyperoncotic colloids in a two hit model of shock: a prospective randomized study.
Critical care (London, England) Jan, 2012 | Pubmed ID: 22277099
[Hemodynamic monitoring - benefit or risk to the patient?].
Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS Feb, 2012 | Pubmed ID: 22402847
[Is there any indication for perioperative use of the pulmonary artery catheter?].
Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS Feb, 2012 | Pubmed ID: 22402850
Antimicrobial peptides and their potential application in inflammation and sepsis.
Critical care (London, England) Mar, 2012 | Pubmed ID: 22429567
Clinical validation of a new thermodilution system for the assessment of cardiac output and volumetric parameters.
Critical care (London, England) May, 2012 | Pubmed ID: 22647561
Effect of empirical treatment with moxifloxacin and meropenem vs meropenem on sepsis-related organ dysfunction in patients with severe sepsis: a randomized trial.
JAMA : the journal of the American Medical Association Jun, 2012 | Pubmed ID: 22692171
Analysis of regional compliance in a porcine model of acute lung injury.
Respiratory physiology & neurobiology Oct, 2012 | Pubmed ID: 22820182
Comments on Reinhart et al.: consensus statement of the ESICM task force on colloid volume therapy in critically ill patients.
Intensive care medicine Sep, 2012 | Pubmed ID: 22829303
[Surgical therapy and critical care medicine in severely burned patients - Part 1: the first 24 ours].
Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS Sep, 2012 | Pubmed ID: 22968982
Selenium blood concentrations in patients undergoing elective cardiac surgery and receiving perioperative sodium selenite.
Nutrition (Burbank, Los Angeles County, Calif.) Jan, 2013 | Pubmed ID: 23010420
The anti-inflammatory effect of the synthetic antimicrobial peptide 19-2.5 in a murine sepsis model: a prospective randomized study.
Critical care (London, England) Jan, 2013 | Pubmed ID: 23302299
[Surgical therapy and critical care medicine in severely burned patients - Part 2: the basics in definite care].
Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS Jan, 2013 | Pubmed ID: 23364820
Discovery and validation of cell cycle arrest biomarkers in human acute kidney injury.
Critical care (London, England) Feb, 2013 | Pubmed ID: 23388612
[Acute renal failure. Despite the new findings, many open questions].
Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS Mar, 2013 | Pubmed ID: 23504466
Goal-directed intraoperative fluid therapy guided by stroke volume and its variation in high-risk surgical patients: a prospective randomized multicentre study.
Journal of clinical monitoring and computing Jun, 2013 | Pubmed ID: 23558909
The German quality indicators in intensive care medicine 2013--second edition.
German medical science : GMS e-journal , 2013 | Pubmed ID: 23904823
[Weaning--definition and clinical context from the anesthetic point of view].
Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS Oct, 2013 | Pubmed ID: 24193689
Accuracy and precision of calibrated arterial pulse contour analysis in patients with subarachnoid hemorrhage requiring high-dose vasopressor therapy: a prospective observational clinical trial.
Critical care (London, England) Feb, 2014 | Pubmed ID: 24499533
[Nutrition in intensive care medicine--how?].
Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS Feb, 2014 | Pubmed ID: 24563400
Major confounders may influence multivariate analysis in a single-center observational study.
Critical care medicine May, 2014 | Pubmed ID: 24736367
Translation control of TAK1 mRNA by hnRNP K modulates LPS-induced macrophage activation.
RNA (New York, N.Y.) Jun, 2014 | Pubmed ID: 24751651
Multicenter, randomized, placebo-controlled phase III study of pyridoxalated hemoglobin polyoxyethylene in distributive shock (PHOENIX).
Critical care medicine Jan, 2015 | Pubmed ID: 25083980
Voluntary peer review as innovative tool for quality improvement in the intensive care unit--a retrospective descriptive cohort study in German intensive care units.
German medical science : GMS e-journal , 2014 | Pubmed ID: 25587245
[Sepsis and multi-organ failure--recognize , understand and treat early].
Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS Feb, 2015 | Pubmed ID: 25723605
Sevoflurane exposure prevents diaphragmatic oxidative stress during mechanical ventilation but reduces force and affects protein metabolism even during spontaneous breathing in a rat model.
Anesthesia and analgesia Jul, 2015 | Pubmed ID: 25851179
Alterations in zinc binding capacity, free zinc levels and total serum zinc in a porcine model of sepsis.
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine Aug, 2015 | Pubmed ID: 25940830
Peptide 19-2.5 inhibits heparan sulfate-triggered inflammation in murine cardiomyocytes stimulated with human sepsis serum.
PloS one , 2015 | Pubmed ID: 26024383
Psychoacoustic analysis of noise and the application of earplugs in an ICU: A randomised controlled clinical trial.
European journal of anaesthesiology Jan, 2016 | Pubmed ID: 26203971
[Tele-cooperation for innovative care using the example of the University Hospital Aachen. Telematics in intensive care medicine, emergency medicine, and telemedical intersectoral rehabilitation planning in geriatric trauma].
Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz Oct, 2015 | Pubmed ID: 26281718
[Telemedicine in Germany].
Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz Oct, 2015 | Pubmed ID: 26293221
Xenon triggers pro-inflammatory effects and suppresses the anti-inflammatory response compared to sevoflurane in patients undergoing cardiac surgery.
Critical care (London, England) Oct, 2015 | Pubmed ID: 26467531
Significant Reduction of External Ventricular Drainage-Associated Meningoventriculitis by Chlorhexidine-Containing Dressings: A Before-After Trial.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America Feb, 2016 | Pubmed ID: 26486701
[Not Available].
Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS Oct, 2015 | Pubmed ID: 26510101
Tissue oxygen saturation as an early indicator of delayed lactate clearance after cardiac surgery: a prospective observational study.
BMC anesthesiology Oct, 2015 | Pubmed ID: 26518485
Soluble Heparan Sulfate in Serum of Septic Shock Patients Induces Mitochondrial Dysfunction in Murine Cardiomyocytes.
Shock (Augusta, Ga.) Dec, 2015 | Pubmed ID: 26529654
miR-155 targets Caspase-3 mRNA in activated macrophages.
RNA biology , 2016 | Pubmed ID: 26574931
The Synthetic Antimicrobial Peptide 19-2.5 Interacts with Heparanase and Heparan Sulfate in Murine and Human Sepsis.
PloS one , 2015 | Pubmed ID: 26600070
Evidence-based fluid management in the ICU.
Current opinion in anaesthesiology Apr, 2016 | Pubmed ID: 26784351
The Human Host Defense Ribonucleases 1, 3 and 7 Are Elevated in Patients with Sepsis after Major Surgery--A Pilot Study.
International journal of molecular sciences Feb, 2016 | Pubmed ID: 26927088
Intensive care medicine: new insights to improve care.
Current opinion in anaesthesiology Apr, 2016 | Pubmed ID: 26934277
[Not Available].
Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS Feb, 2016 | Pubmed ID: 26949904
[Not Available].
Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS Mar, 2016 | Pubmed ID: 27022695
Designing phase 3 sepsis trials: application of learned experiences from critical care trials in acute heart failure.
Journal of intensive care , 2016 | Pubmed ID: 27034779
Intravascular volume therapy in adults: Guidelines from the Association of the Scientific Medical Societies in Germany.
European journal of anaesthesiology Jul, 2016 | Pubmed ID: 27043493
Myocardial Ischemia Induces SDF-1α Release in Cardiac Surgery Patients.
Journal of cardiovascular translational research Jun, 2016 | Pubmed ID: 27055858
Identification of RNA-binding Proteins in Macrophages by Interactome Capture.
Molecular & cellular proteomics : MCP Aug, 2016 | Pubmed ID: 27281784
Chemokine (C-C motif) receptor 2-positive monocytes aggravate the early phase of acetaminophen-induced acute liver injury.
Hepatology (Baltimore, Md.) Nov, 2016 | Pubmed ID: 27302828
Effect of Sodium Selenite Administration and Procalcitonin-Guided Therapy on Mortality in Patients With Severe Sepsis or Septic Shock: A Randomized Clinical Trial.
JAMA internal medicine Sep, 2016 | Pubmed ID: 27428731
The Ribonuclease A Superfamily in Humans: Canonical RNases as the Buttress of Innate Immunity.
International journal of molecular sciences Aug, 2016 | Pubmed ID: 27527162
Influence of weaning methods on the diaphragm after mechanical ventilation in a rat model.
BMC pulmonary medicine Aug, 2016 | Pubmed ID: 27558126
The synthetic antimicrobial peptide 19-2.5 attenuates mitochondrial dysfunction in cardiomyocytes stimulated with human sepsis serum.
Innate immunity Nov, 2016 | Pubmed ID: 27624711
Effect of Hydrocortisone on Development of Shock Among Patients With Severe Sepsis: The HYPRESS Randomized Clinical Trial.
JAMA Nov, 2016 | Pubmed ID: 27695824
Perioperative intravenous fluid therapy in children: guidelines from the Association of the Scientific Medical Societies in Germany.
Paediatric anaesthesia Jan, 2017 | Pubmed ID: 27747968
Kinetics of ventilation-induced changes in diaphragmatic metabolism by bilateral phrenic pacing in a piglet model.
Scientific reports Oct, 2016 | Pubmed ID: 27759115
The synthetic antimicrobial peptide 19-2.5 attenuates septic cardiomyopathy and prevents down-regulation of SERCA2 in polymicrobial sepsis.
Scientific reports Nov, 2016 | Pubmed ID: 27853260
Plasma adrenomedullin in critically ill patients with sepsis after major surgery: A pilot study.
Journal of critical care Oct, 2016 | Pubmed ID: 27865148
Reply to: volume therapy in obstetrics.
European journal of anaesthesiology Feb, 2017 | Pubmed ID: 28027210
Christoph Emontzpohl1,2,
David Simons3,
Sandra Kraemer4,
Andreas Goetzenich4,
Gernot Marx1,
Jürgen Bernhagen5,6,
Christian Stoppe1
1Department of Intensive Care Medicine, University Hospital Aachen,
2Institute of Biochemistry and Molecular Biology, University Hospital Aachen,
3Department of Radiology, German Cancer Research Center,
4Department of Thoracic and Cardiovascular Surgery, University Hospital Aachen,
5Department of Vascular Biology, Institute for Stroke and Dementia Research (ISD), Klinikum der Universität München,
6Deutsches Zentrum für Herz-/Kreislaufkrankheiten (DZHK), Munich Heart Alliance
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