Chung-Yi Wu

Stereoselective glycosylation of exo-glycals accelerated by Ferrier-type rearrangement.

Rapid diversity-oriented synthesis in microtiter plates for in situ screening: discovery of potent and selective alpha-fucosidase inhibitors.

Small molecules targeting severe acute respiratory syndrome human coronavirus.

Discovery of picomolar slow tight-binding inhibitors of alpha-fucosidase.

Stable benzotriazole esters as mechanism-based inactivators of the severe acute respiratory syndrome 3CL protease.

Discovery of different types of inhibition between the human and thermotoga maritima alpha-fucosidases by fuconojirimycin-based derivatives.

Glycan arrays on aluminum-coated glass slides.

Glycan microarray of Globo H and related structures for quantitative analysis of breast cancer.

HA-pseudotyped retroviral vectors for influenza antagonist screening.

New development of glycan arrays.

Iron oxide/gold core/shell nanoparticles for ultrasensitive detection of carbohydrate-protein interactions.

Glycans on influenza hemagglutinin affect receptor binding and immune response.

Glycan array: a powerful tool for glycomics studies.

Highly alpha-selective sialyl phosphate donors for efficient preparation of natural sialosides.

Ultrasound ionization of biomolecules.

Glycan array on aluminum oxide-coated glass slides through phosphonate chemistry.

Differential receptor binding affinities of influenza hemagglutinins on glycan arrays.

Ubiquitination and deubiquitination of NP protein regulates influenza A virus RNA replication.

High-throughput identification of compounds targeting influenza RNA-dependent RNA polymerase activity.

Carbohydrate-based vaccines: challenges and opportunities.

Programmable one-pot glycosylation.

Effects of neighboring glycans on antibody-carbohydrate interaction.

Broadly neutralizing DNA vaccine with specific mutation alters the antigenicity and sugar-binding activities of influenza hemagglutinin.

Chemistry and glycobiology.

The SUMOylation of matrix protein M1 modulates the assembly and morphogenesis of influenza A virus.

Hemagglutinin-neuraminidase balance confers respiratory-droplet transmissibility of the pandemic H1N1 influenza virus in ferrets.

Efficient and stereoselective synthesis of α(2→9) oligosialic acids: from monomers to dodecamers.

Toward automated oligosaccharide synthesis.

Infection of differentiated porcine airway epithelial cells by influenza virus: differential susceptibility to infection by porcine and avian viruses.

Cancer-associated carbohydrate antigens as potential biomarkers for hepatocellular carcinoma.

Chemical probes for drug-resistance assessment by binding competition (RABC): oseltamivir susceptibility evaluation.

Carbohydrate-based vaccines with a glycolipid adjuvant for breast cancer.

The immunologically active oligosaccharides isolated from wheatgrass modulate monocytes via Toll-like receptor-2 signaling.

CLEC4F is an inducible C-type lectin in F4/80-positive cells and is involved in alpha-galactosylceramide presentation in liver.

Different immunity elicited by recombinant H5N1 hemagglutinin proteins containing pauci-mannose, high-mannose, or complex type N-glycans.

Synthesis and vaccine evaluation of the tumor-associated carbohydrate antigen RM2 from prostate cancer.

Synthesis of Neisseria meningitidis serogroup W135 capsular oligosaccharides for immunogenicity comparison and vaccine development.

Immunization of fucose-containing polysaccharides from Reishi mushroom induces antibodies to tumor-associated Globo H-series epitopes.

Efficient convergent synthesis of bi-, tri-, and tetra-antennary complex type N-glycans and their HIV-1 antigenicity.

Effective sugar nucleotide regeneration for the large-scale enzymatic synthesis of Globo H and SSEA4.

Downregulation of microRNA-15b by hepatitis B virus X enhances hepatocellular carcinoma proliferation via fucosyltransferase 2-induced Globo H expression.

Global assessment of Antrodia cinnamomea-induced microRNA alterations in hepatocarcinoma cells.

Vaccination of monoglycosylated hemagglutinin induces cross-strain protection against influenza virus infections.

Chemical constituents of Plectranthus amboinicus and the synthetic analogs possessing anti-inflammatory activity.

Stage-specific embryonic antigen-4 as a potential therapeutic target in glioblastoma multiforme and other cancers.

Characterization of the sialic acid binding activity of influenza A viruses using soluble variants of the H7 and H9 hemagglutinins.

Broadly neutralizing HIV antibodies define a glycan-dependent epitope on the prefusion conformation of gp41 on cleaved envelope trimers.

Development of a highly sensitive glycan microarray for quantifying AFP-L3 for early prediction of hepatitis B virus-related hepatocellular carcinoma.

Sequence-constructive SELEX: a new strategy for screening DNA aptamer binding to Globo H.

Immunogenicity study of Globo H analogues with modification at the reducing or nonreducing end of the tumor antigen.

Sialoside Arrays: New Synthetic Strategies and Applications.

Human CLEC18 Gene Cluster Contains C-type Lectins with Differential Glycan-binding Specificity.

A common glycan structure on immunoglobulin G for enhancement of effector functions.

Identification of Common Features in Prototype Broadly Neutralizing Antibodies to HIV Envelope V2 Apex to Facilitate Vaccine Design.

Modular synthesis of N-glycans and arrays for the hetero-ligand binding analysis of HIV antibodies.

A Multivalent Marine Lectin from Crenomytilus grayanus Possesses Anti-cancer Activity through Recognizing Globotriose Gb3.

Trimeric HIV-1-Env Structures Define Glycan Shields from Clades A, B, and G.

Early Antibody Lineage Diversification and Independent Limb Maturation Lead to Broad HIV-1 Neutralization Targeting the Env High-Mannose Patch.

A Prominent Site of Antibody Vulnerability on HIV Envelope Incorporates a Motif Associated with CCR5 Binding and Its Camouflaging Glycans.

Functionalized HgTe nanoparticles promote laser-induced solid phase ionization/dissociation for comprehensive glycan sequencing.

Influenza A surface glycosylation and vaccine design.

An Effective Bacterial Fucosidase for Glycoprotein Remodeling.

Structural basis for fragmenting the exopolysaccharide of Acinetobacter baumannii by bacteriophage ΦAB6 tailspike protein.

Crystal Structure of a Homogeneous IgG-Fc Glycoform with the N-Glycan Designed to Maximize the Antibody Dependent Cellular Cytotoxicity.

Glycans Function as Anchors for Antibodies and Help Drive HIV Broadly Neutralizing Antibody Development.

Glycoengineering of antibody (Herceptin) through yeast expression and in vitro enzymatic glycosylation.

Defining the sizes of airborne particles that mediate influenza transmission in ferrets.

A Neutralizing Antibody Recognizing Primarily N-Linked Glycan Targets the Silent Face of the HIV Envelope.

Unprecedented Role of Hybrid N-Glycans as Ligands for HIV-1 Broadly Neutralizing Antibodies.

-GlcNAcylation regulates the stability and enzymatic activity of the histone methyltransferase EZH2.

Pseudaminic Acid on Exopolysaccharide of Acinetobacter baumannii Plays a Critical Role in Phage-Assisted Preparation of Glycoconjugate Vaccine with High Antigenicity.

Preparation of Aluminum Oxide-Coated Glass Slides for Glycan Microarrays.

Dual CLAVATA3 Peptides in Arabidopsis Shoot Stem Cell Signaling.

Hierarchical and programmable one-pot synthesis of oligosaccharides.

Signaling pathway of globo-series glycosphingolipids and β1,3-galactosyltransferase V (β3GalT5) in breast cancer.

The uremic toxin p-cresyl sulfate induces proliferation and migration of clear cell renal cell carcinoma via microRNA-21/ HIF-1α axis signals.

Synthesis of Sialidase-Resistant Oligosaccharide and Antibody Glycoform Containing α2,6-Linked 3F-Neu5Ac.

Functional roles of ST8SIA3-mediated sialylation of striatal dopamine D and adenosine A receptors.