Christopher Chen

Apolipoprotein ɛ4 is Associated with Dementia and Cognitive Impairment Predominantly Due to Alzheimer's Disease and Not with Vascular Cognitive Impairment: A Singapore-Based Cohort.

Differential involvement of hippocampal serotonin1A receptors and re-uptake sites in non-cognitive behaviors of Alzheimer's disease.

The Montreal Cognitive Assessment (MoCA) is superior to the Mini-Mental State Examination (MMSE) for the detection of vascular cognitive impairment after acute stroke.

Hippocampal neurofibrillary tangle changes and aggressive behaviour in dementia.

Intact cannabinoid CB1 receptors in the Alzheimer's disease cortex.

Cortisol response to individualised graded insulin infusions: a reproducible biomarker for CNS compounds inhibiting HPA activation.

Upregulation of AMPA receptor GluR2 (GluA2) subunits in subcortical ischemic vascular dementia is repressed in the presence of Alzheimer's disease.

Preservation of cortical histamine H3 receptors in ischemic vascular and mixed dementias.

Brief screening tests during acute admission in patients with mild stroke are predictive of vascular cognitive impairment 3-6 months after stroke.

The Montreal Cognitive Assessment is superior to the Mini-Mental State Examination in detecting patients at higher risk of dementia.

Changes in cerebral hemodynamic and cognitive parameters after external carotid-internal carotid bypass surgery in patients with severe steno-occlusive disease: a pilot study.

The informant AD8 is superior to participant AD8 in detecting cognitive impairment in a memory clinic setting.

The NeuroAiD II (MLC901) in Vascular Cognitive Impairment Study (NEURITES).

Patterns of neuropsychological impairment in Alzheimer's disease and mixed dementia.

Cognitive screening improves the predictive value of stroke severity scores for functional outcome 3-6 months after mild stroke and transient ischaemic attack: an observational study.

Decreased rabphilin 3A immunoreactivity in Alzheimer's disease is associated with Aβ burden.

Cerebral microbleeds and cognition: the epidemiology of dementia in Singapore study.

Improving screening for vascular cognitive impairment at three to six months after mild ischemic stroke and transient ischemic attack.

Microvascular network alterations in the retina of patients with Alzheimer's disease.

Novel pathophysiological markers are revealed by iTRAQ-based quantitative clinical proteomics approach in vascular dementia.

Diagnostic Criteria for Vascular Cognitive Disorders: A VASCOG Statement.

Brain lipidomes of subcortical ischemic vascular dementia and mixed dementia.

Intracranial stenosis, cerebrovascular diseases, and cognitive impairment in chinese.

Discovery of prognostic biomarker candidates of lacunar infarction by quantitative proteomics of microvesicles enriched plasma.

Computer tomography for prediction of cognitive outcomes after ischemic cerebrovascular events.

A pilot study to examine the correlation between cognition and blood biomarkers in a Singapore Chinese male cohort with type 2 diabetes mellitus.

Microvascular network alterations in retina of subjects with cerebral small vessel disease.

Differential alterations of neocortical GluN receptor subunits in patients with mixed subcortical ischemic vascular dementia and Alzheimer's disease.

Retinal vascular fractals and cognitive impairment.

Retinal microvasculature in Alzheimer's disease.

Retinal ganglion cell analysis using high-definition optical coherence tomography in patients with mild cognitive impairment and Alzheimer's disease.

Retinal neurodegeneration on optical coherence tomography and cerebral atrophy.

Temporal lobe proteins implicated in synaptic failure exhibit differential expression and deamidation in vascular dementia.

Feasibility and acceptability of the informant AD8 for cognitive screening in primary healthcare: a pilot study.

Markers of cardiac dysfunction in cognitive impairment and dementia.

Cortical microinfarcts on 3T MRI: Clinical correlates in memory-clinic patients.

Risk Factors and Consequences of Cortical Thickness in an Asian Population.

Association of neuropsychiatric symptoms and sub-syndromes with cognitive impairment in community-dwelling Asian elderly.

Prevalence and Risk Factors of Acute Incidental Infarcts.

Association of Magnetic Resonance Imaging Markers of Cerebrovascular Disease Burden and Cognition.

Differential interaction of Apolipoprotein-E isoforms with insulin receptors modulates brain insulin signaling in mutant human amyloid precursor protein transgenic mice.

Subcortical Atrophy in Cognitive Impairment and Dementia.

Extracellular vesicles are rapidly purified from human plasma by PRotein Organic Solvent PRecipitation (PROSPR).

Prevalence of Cognitive Impairment and Dementia in Malays - Epidemiology of Dementia in Singapore Study.

Ocular Fundus Photography as a Tool to Study Stroke and Dementia.

Clinical utility of the informant AD8 as a dementia case finding instrument in primary healthcare.

Inter-Dependent Mechanisms Behind Cognitive Dysfunction, Vascular Biology and Alzheimer's Dementia in Down Syndrome: Multi-Faceted Roles of APP.

Rapid Screening for Cognitive Impairment in Parkinson's Disease: A Pilot Study.

Risk Factors of Cognitive Impairment and Brief Cognitive Tests to Predict Cognitive Performance Determined by a Formal Neuropsychological Evaluation of Primary Health Care Patients.

Beyond Screening: Can the Mini-Mental State Examination be Used as an Exclusion Tool in a Memory Clinic?

The Combined Utility of a Brief Functional Measure and Performance-Based Screening Test for Case Finding of Cognitive Impairment in Primary Healthcare.

Gender differences in white matter pathology and mitochondrial dysfunction in Alzheimer's disease with cerebrovascular disease.

The Montreal Cognitive Assessment is superior to National Institute of Neurological Disease and Stroke-Canadian Stroke Network 5-minute protocol in predicting vascular cognitive impairment at 1 year.

Validation of the Total Cerebrovascular Disease Burden Scale in a Community Sample.

ApoE4 expression accelerates hippocampus-dependent cognitive deficits by enhancing Aβ impairment of insulin signaling in an Alzheimer's disease mouse model.

A priori collaboration in population imaging: The Uniform Neuro-Imaging of Virchow-Robin Spaces Enlargement consortium.

Cerebral microbleeds and neuropsychiatric symptoms in an elderly Asian cohort.

Changing Patterns of Patient Characteristics in a Memory Clinic in Singapore.

Intracranial stenosis in cognitive impairment and dementia.

The Diagnostic Utility of the NINDS-CSN Neuropsychological Battery in Memory Clinics.

Growth differentiation factor-15 and white matter hyperintensities in cognitive impairment and dementia.

The Association Between Retinal Neuronal Layer and Brain Structure is Disrupted in Patients with Cognitive Impairment and Alzheimer's Disease.

Inter-hemispheric functional dysconnectivity mediates the association of corpus callosum degeneration with memory impairment in AD and amnestic MCI.

Cortical cerebral microinfarcts on 3T MRI: A novel marker of cerebrovascular disease.

Increased phosphorylation of collapsin response mediator protein-2 at Thr514 correlates with β-amyloid burden and synaptic deficits in Lewy body dementias.

Poststroke Cognitive Decline is Independent of Longitudinal Changes in Cerebral Hemodynamics Parameters.

Muscarinic M1 Receptor Coupling to G-protein is Intact in Parkinson's Disease Dementia.

Novel genetic loci underlying human intracranial volume identified through genome-wide association.

Evaluation of an fMRI USPIO-based assay in healthy human volunteers.

Impact of Strategically Located White Matter Hyperintensities on Cognition in Memory Clinic Patients with Small Vessel Disease.

Prognostic Factors and Pattern of Long-Term Recovery with MLC601 (NeuroAiD™) in the Chinese Medicine NeuroAiD Efficacy on Stroke Recovery - Extension Study.

Imaging retina to study dementia and stroke.

Evidence that NF-κB and MAPK Signaling Promotes NLRP Inflammasome Activation in Neurons Following Ischemic Stroke.

Association Between Subclinical Cardiac Biomarkers and Clinically Manifest Cardiac Diseases With Cortical Cerebral Microinfarcts.

Serum IL-8 is a marker of white-matter hyperintensities in patients with Alzheimer's disease.

Decline in changing Montreal Cognitive Assessment (MoCA) scores is associated with post-stroke cognitive decline determined by a formal neuropsychological evaluation.

Prevalence, risk factors and consequences of cerebral small vessel diseases: data from three Asian countries.

Ankle brachial index, MRI markers and cognition: The Epidemiology of Dementia in Singapore study.

Detection, risk factors, and functional consequences of cerebral microinfarcts.

Distinct white matter microstructural abnormalities and extracellular water increases relate to cognitive impairment in Alzheimer's disease with and without cerebrovascular disease.

Repeatability and Reproducibility of Retinal Neuronal and Axonal Measures on Spectral-Domain Optical Coherence Tomography in Patients with Cognitive Impairment.

Influence of cerebrovascular disease on brain networks in prodromal and clinical Alzheimer's disease.