Denis Wirtz

Shape anisotropy of a single random-walk polymer.

The nonhelical tail domain of keratin 14 promotes filament bundling and enhances the mechanical properties of keratin intermediate filaments in vitro.

Pairwise assembly determines the intrinsic potential for self-organization and mechanical properties of keratin filaments.

Microheterogeneity controls the rate of gelation of actin filament networks.

Functional synergy of actin filament cross-linking proteins.

Micromechanical coupling between cell surface receptors and RGD peptides.

Effect of length, topology, and concentration on the microviscosity and microheterogeneity of DNA solutions.

Micromechanical mapping of live cells by multiple-particle-tracking microrheology.

Single molecule characterization of P-selectin/ligand binding.

A mechanism of coupling RCC1 mobility to RanGTP production on the chromatin in vivo.

Efficient active transport of gene nanocarriers to the cell nucleus.

The mechanical properties of simple epithelial keratins 8 and 18: discriminating between interfacial and bulk elasticities.

Receptor-ligand binding: 'catch' bonds finally caught.

Enhanced viscoelasticity of human cystic fibrotic sputum correlates with increasing microheterogeneity in particle transport.

The bimodal role of filamin in controlling the architecture and mechanics of F-actin networks.

Real-time intracellular transport of gene nanocarriers studied by multiple particle tracking.

Micro-organization and visco-elasticity of the interphase nucleus revealed by particle nanotracking.

Rho kinase regulates the intracellular micromechanical response of adherent cells to rho activation.

Distinct kinetic and mechanical properties govern selectin-leukocyte interactions.

Transport of polymeric nanoparticle gene carriers in gastric mucus.

Nuclear envelope breakdown requires overcoming the mechanical integrity of the nuclear lamina.

Intracellular mechanics of migrating fibroblasts.

The assembly of MreB, a prokaryotic homolog of actin.

Cdc42 mediates nucleus movement and MTOC polarization in Swiss 3T3 fibroblasts under mechanical shear stress.

Structure-function relationship of biological gels revealed by multiple-particle tracking and differential interference contrast microscopy: the case of human lamin networks.

Intracellular microrheology as a tool for the measurement of the local mechanical properties of live cells.

Dendritic branching and homogenization of actin networks mediated by arp2/3 complex.

Cell migration without a lamellipodium: translation of actin dynamics into cell movement mediated by tropomyosin.

The rapid onset of elasticity during the assembly of the bacterial cell-division protein FtsZ.

How actin crosslinking and bundling proteins cooperate to generate an enhanced cell mechanical response.

Morphology of the lamellipodium and organization of actin filaments at the leading edge of crawling cells.

Mechanical shear can accelerate the gelation of actin filament networks.

Mechanics and dynamics of actin-driven thin membrane protrusions.

Single-molecule analysis of human immunodeficiency virus type 1 gp120-receptor interactions in living cells.

Mechanics of enveloped virus entry into host cells.

Single-molecule analysis of cadherin-mediated cell-cell adhesion.

GTPase activity, structure, and mechanical properties of filaments assembled from bacterial cytoskeleton protein MreB.

Probing intercellular interactions between vascular endothelial cadherin pairs at single-molecule resolution and in living cells.

Probing single-cell micromechanics in vivo: the microrheology of C. elegans developing embryos.

Ballistic intracellular nanorheology reveals ROCK-hard cytoplasmic stiffening response to fluid flow.

Microrheology and ROCK signaling of human endothelial cells embedded in a 3D matrix.

A direct interaction between actin and vimentin filaments mediated by the tail domain of vimentin.

Probing cellular mechanical responses to stimuli using ballistic intracellular nanorheology.

Nuclear lamin A/C deficiency induces defects in cell mechanics, polarization, and migration.

MinC spatially controls bacterial cytokinesis by antagonizing the scaffolding function of FtsZ.

Structural requirements for the assembly of LINC complexes and their function in cellular mechanical stiffness.

Fibronectin fibrillogenesis regulates three-dimensional neovessel formation.

Monitoring early fusion dynamics of human immunodeficiency virus type 1 at single-molecule resolution.

Polymerization and bundling kinetics of FtsZ filaments.

Mapping local matrix remodeling induced by a migrating tumor cell using three-dimensional multiple-particle tracking.

Dysfunctional connections between the nucleus and the actin and microtubule networks in laminopathic models.

The filamentous actin cross-linking/bundling activity of mammalian formins.

{alpha}-Catenin mediates initial E-cadherin-dependent cell-cell recognition and subsequent bond strengthening.

Condensation of FtsZ filaments can drive bacterial cell division.

Chapter 15: Live-cell single-molecule force spectroscopy.

Chapter 18: Sensing cytoskeletal mechanics by ballistic intracellular nanorheology (BIN) coupled with cell transfection.

Micro- and macrorheology of mucus.

Altering mucus rheology to "solidify" human mucus at the nanoscale.

Programmed subcellular release for studying the dynamics of cell detachment.

Alpha-actinin and filamin cooperatively enhance the stiffness of actin filament networks.

Asymmetric enrichment of PIE-1 in the Caenorhabditis elegans zygote mediated by binary counterdiffusion.

Magnetic tweezers measurement of single molecule torque.

Particle-tracking microrheology of living cells: principles and applications.

Loss of alpha-catenin decreases the strength of single E-cadherin bonds between human cancer cells.

Resolving the role of actoymyosin contractility in cell microrheology.

A perinuclear actin cap regulates nuclear shape.

Dynamics of the bacterial intermediate filament crescentin in vitro and in vivo.

A distinctive role for focal adhesion proteins in three-dimensional cell motility.

Triggering cell detachment from patterned electrode arrays by programmed subcellular release.

MEX-5 enrichment in the C. elegans early embryo mediated by differential diffusion.

Organization of cellular receptors into a nanoscale junction during HIV-1 adhesion.

PEG-based hydrogels with collagen mimetic peptide-mediated and tunable physical cross-links.

Cross-linking FtsZ polymers into coherent Z rings.

Torsional mechanics of DNA are regulated by small-molecule intercalation.

Interplay of RhoA and motility in the programmed spreading of daughter cells postmitosis.

Differences in the microrheology of human embryonic stem cells and human induced pluripotent stem cells.

Biophysics of selectin-ligand interactions in inflammation and cancer.

The perinuclear actin cap in health and disease.

Recapitulating cancer cell invasion in vitro.

Single-molecule binding of CD44 to fibrin versus P-selectin predicts their distinct shear-dependent interactions in cancer.

The physics of cancer: the role of physical interactions and mechanical forces in metastasis.

Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation.

Magnetic manipulation of nanorods in the nucleus of living cells.

SMRT analysis of MTOC and nuclear positioning reveals the role of EB1 and LIC1 in single-cell polarization.

Nucleation and decay initiation are the stiffness-sensitive phases of focal adhesion maturation.

High-throughput ballistic injection nanorheology to measure cell mechanics.

Dimensional and temporal controls of three-dimensional cell migration by zyxin and binding partners.

Divergent roles of CD44 and carcinoembryonic antigen in colon cancer metastasis.

The differential formation of the LINC-mediated perinuclear actin cap in pluripotent and somatic cells.

Mismatch in mechanical and adhesive properties induces pulsating cancer cell migration in epithelial monolayer.

NAC1 is an actin-binding protein that is essential for effective cytokinesis in cancer cells.

The distinct roles of the nucleus and nucleus-cytoskeleton connections in three-dimensional cell migration.

Effect of modifying quantum dot surface charge on airway epithelial cell uptake in vitro.

Actin cap associated focal adhesions and their distinct role in cellular mechanosensing.

Distinct kinetic and molecular requirements govern CD44 binding to hyaluronan versus fibrin(ogen).

Focal adhesion size uniquely predicts cell migration.

Functional interplay between the cell cycle and cell phenotypes.

The LINC-anchored actin cap connects the extracellular milieu to the nucleus for ultrafast mechanotransduction.

High-throughput secretomic analysis of single cells to assess functional cellular heterogeneity.

Procollagen lysyl hydroxylase 2 is essential for hypoxia-induced breast cancer metastasis.

Hypoxia-inducible factor 1 (HIF-1) promotes extracellular matrix remodeling under hypoxic conditions by inducing P4HA1, P4HA2, and PLOD2 expression in fibroblasts.

Dimensional control of cancer cell migration.

Interstitial friction greatly impacts membrane mechanics.

Simultaneously defining cell phenotypes, cell cycle, and chromatin modifications at single-cell resolution.

Collagen prolyl hydroxylases are essential for breast cancer metastasis.

Predicting how cells spread and migrate: focal adhesion size does matter.

Age-dependent stochastic models for understanding population fluctuations in continuously cultured cells.

The Arp2/3 complex mediates multigeneration dendritic protrusions for efficient 3-dimensional cancer cell migration.

The multi-faceted role of the actin cap in cellular mechanosensation and mechanotransduction.

Morphological effects on expression of growth differentiation factor 15 (GDF15), a marker of metastasis.

Modulation of keratocyte phenotype by collagen fibril nanoarchitecture in membranes for corneal repair.

Adhesion and fusion efficiencies of human immunodeficiency virus type 1 (HIV-1) surface proteins.

Form-finding model shows how cytoskeleton network stiffness is realized.

β-Catenin serves as a clutch between low and high intercellular E-cadherin bond strengths.

Hypoxia-inducible factors mediate coordinated RhoA-ROCK1 expression and signaling in breast cancer cells.

Nuclear envelope in nuclear positioning and cell migration.

Three-dimensional cell migration does not follow a random walk.

Tight coupling between nucleus and cell migration through the perinuclear actin cap.

Local mechanical response of cells to the controlled rotation of magnetic nanorods.

Water permeation drives tumor cell migration in confined microenvironments.

Hypoxia and the extracellular matrix: drivers of tumour metastasis.

Switching from protease-independent to protease-dependent cancer cell invasion.

Cytoskeletal tension induces the polarized architecture of the nucleus.

COX-2 dependent regulation of mechanotransduction in human breast cancer cells.

Statistical analysis of cell migration in 3D using the anisotropic persistent random walk model.

Inhibition of Spleen Tyrosine Kinase Potentiates Paclitaxel-Induced Cytotoxicity in Ovarian Cancer Cells by Stabilizing Microtubules.

Multiple scale model for cell migration in monolayers: Elastic mismatch between cells enhances motility.

Volume regulation and shape bifurcation in the cell nucleus.

Distinct kinetic and mechanical properties govern mucin 16- and podocalyxin-mediated tumor cell adhesion to E- and L-selectin in shear flow.

Normal mammary epithelial cells promote carcinoma basement membrane invasion by inducing microtubule-rich protrusions.

Three-dimensional matrix fiber alignment modulates cell migration and MT1-MMP utility by spatially and temporally directing protrusions.

Senescent stromal cells induce cancer cell migration via inhibition of RhoA/ROCK/myosin-based cell contractility.

Local 3D matrix confinement determines division axis through cell shape.

Collective cancer cell invasion induced by coordinated contractile stresses.

The Mechanobiology of Aging.

Evolution of cellular morpho-phenotypes in cancer metastasis.

A robust nonlinear tissue-component discrimination method for computational pathology.

Differential vesicular sorting of AMPA and GABAA receptors.

Biophysical changes reduce energetic demand in growth factor-deprived lymphocytes.

Confinement Sensing and Signal Optimization via Piezo1/PKA and Myosin II Pathways.

Engineered Models of Confined Cell Migration.

Transient Opening of the Mitochondrial Permeability Transition Pore Induces Microdomain Calcium Transients in Astrocyte Processes.

Modeling the two-way feedback between contractility and matrix realignment reveals a nonlinear mode of cancer cell invasion.

Hypoxia Selectively Enhances Integrin α5β1 Receptor Expression in Breast Cancer to Promote Metastasis.

Affine and non-affine deformations quantified in cytoskeletal networks through three-dimensional form-finding model.

Synergistic IL-6 and IL-8 paracrine signalling pathway infers a strategy to inhibit tumour cell migration.

Pluri-IQ: Quantification of Embryonic Stem Cell Pluripotency through an Image-Based Analysis Software.

Loss of giant obscurins alters breast epithelial cell mechanosensing of matrix stiffness.

EB1 and cytoplasmic dynein mediate protrusion dynamics for efficient 3-dimensional cell migration.