Fadi F. Hamdan

Conformational changes that occur during M3 muscarinic acetylcholine receptor activation probed by the use of an in situ disulfide cross-linking strategy.

A novel Schistosoma mansoni G protein-coupled receptor is responsive to histamine.

A Schistosoma mansoni Pad1 homologue stabilizes c-Jun.

Use of an in situ disulfide cross-linking strategy to map proximities between amino acid residues in transmembrane domains I and VII of the M3 muscarinic acetylcholine receptor.

Codon optimization improves heterologous expression of a Schistosoma mansoni cDNA in HEK293 cells.

Pronounced conformational changes following agonist activation of the M(3) muscarinic acetylcholine receptor.

Identification of an agonist-induced conformational change occurring adjacent to the ligand-binding pocket of the M(3) muscarinic acetylcholine receptor.

High-throughput screening of G protein-coupled receptor antagonists using a bioluminescence resonance energy transfer 1-based beta-arrestin2 recruitment assay.

Use of an in situ disulfide cross-linking strategy to study the dynamic properties of the cytoplasmic end of transmembrane domain VI of the M3 muscarinic acetylcholine receptor.

A critical role for beta cell M3 muscarinic acetylcholine receptors in regulating insulin release and blood glucose homeostasis in vivo.

Calcitonin gene-related peptide analogues with aza and indolizidinone amino acid residues reveal conformational requirements for antagonist activity at the human calcitonin gene-related peptide 1 receptor.

Src-dependent phosphorylation of beta2-adaptin dissociates the beta-arrestin-AP-2 complex.

Distinct structural changes in a G protein-coupled receptor caused by different classes of agonist ligands.

Unraveling G protein-coupled receptor endocytosis pathways using real-time monitoring of agonist-promoted interaction between beta-arrestins and AP-2.

Ligand-specific changes in M3 muscarinic acetylcholine receptor structure detected by a disulfide scanning strategy.

Monitoring protein-protein interactions in living cells by bioluminescence resonance energy transfer (BRET).

Metabolic roles of the M3 muscarinic acetylcholine receptor studied with M3 receptor mutant mice: a review.

Novel de novo SHANK3 mutation in autistic patients.

Mutations in the calcium-related gene IL1RAPL1 are associated with autism.

Mutations in SYNGAP1 in autosomal nonsyndromic mental retardation.

Neuronal M3 muscarinic acetylcholine receptors are essential for somatotroph proliferation and normal somatic growth.

No association between SRGAP3/MEGAP haploinsufficiency and mental retardation.

De novo STXBP1 mutations in mental retardation and nonsyndromic epilepsy.

[De novo mutations in SYNGAP1 associated with non-syndromic mental retardation].

De novo mutations in the gene encoding the synaptic scaffolding protein SHANK3 in patients ascertained for schizophrenia.

De novo truncating mutation in Kinesin 17 associated with schizophrenia.

Direct measure of the de novo mutation rate in autism and schizophrenia cohorts.

De novo mutations in FOXP1 in cases with intellectual disability, autism, and language impairment.

M3-muscarinic receptor promotes insulin release via receptor phosphorylation/arrestin-dependent activation of protein kinase D1.

De novo SYNGAP1 mutations in nonsyndromic intellectual disability and autism.

Intellectual disability without epilepsy associated with STXBP1 disruption.

Excess of de novo deleterious mutations in genes associated with glutamatergic systems in nonsyndromic intellectual disability.

A population genetic approach to mapping neurological disorder genes using deep resequencing.

Truncating mutations in NRXN2 and NRXN1 in autism spectrum disorders and schizophrenia.

Identification of a novel in-frame de novo mutation in SPTAN1 in intellectual disability and pontocerebellar atrophy.