Valter D. Longo

Peroxynitrite mediates neurotoxicity of amyloid beta-peptide1-42- and lipopolysaccharide-activated microglia.

Genetics of aging and diseases: from rare mutations and model systems to disease prevention.

SOD2 functions downstream of Sch9 to extend longevity in yeast.

Evolutionary medicine: from dwarf model systems to healthy centenarians?

The Ras and Sch9 pathways regulate stress resistance and longevity.

The chronological life span of Saccharomyces cerevisiae.

Oxygen? No thanks, I'm on a diet.

Biodemographic trajectories of age-specific reproliferation from stationary phase in the yeast Saccharomyces cerevisiae seem multiphasic.

Search for methuselah genes heats up.

Superoxide inhibits 4Fe-4S cluster enzymes involved in amino acid biosynthesis. Cross-compartment protection by CuZn-superoxide dismutase.

Superoxide is a mediator of an altruistic aging program in Saccharomyces cerevisiae.

Ras: the other pro-aging pathway.

Analysis of gene expression profile in yeast aging chronologically.

Sir2 blocks extreme life-span extension.

Programmed and altruistic ageing.

Aging as a mitochondria-mediated atavistic program: can aging be switched off?

Sirtuins in aging and age-related disease.

Inference of transcription modification in long-live yeast strains from their expression profiles.

The chronological life span of Saccharomyces cerevisiae.

Significant and systematic expression differentiation in long-lived yeast strains.

Longevity mutation in SCH9 prevents recombination errors and premature genomic instability in a Werner/Bloom model system.

Life span extension by calorie restriction depends on Rim15 and transcription factors downstream of Ras/PKA, Tor, and Sch9.

Starvation-dependent differential stress resistance protects normal but not cancer cells against high-dose chemotherapy.

Chronological aging-induced apoptosis in yeast.

SirT1 inhibition reduces IGF-I/IRS-2/Ras/ERK1/2 signaling and protects neurons.

Linking sirtuins, IGF-I signaling, and starvation.

The chronological life span of Saccharomyces cerevisiae to study mitochondrial dysfunction and disease.

Turning anti-ageing genes against cancer.

Tor1/Sch9-regulated carbon source substitution is as effective as calorie restriction in life span extension.

Oncogene homologue Sch9 promotes age-dependent mutations by a superoxide and Rev1/Polzeta-dependent mechanism.

Comparative analyses of time-course gene expression profiles of the long-lived sch9Delta mutant.

Calorie restriction and cancer prevention: metabolic and molecular mechanisms.

Insulin/IGF-I and related signaling pathways regulate aging in nondividing cells: from yeast to the mammalian brain.

Reduced levels of IGF-I mediate differential protection of normal and cancer cells in response to fasting and improve chemotherapeutic index.

Fasting and cancer treatment in humans: A case series report.

Extending healthy life span--from yeast to humans.

Cell resilience in species life spans: a link to inflammation?

Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation.

SIRT1 is essential for normal cognitive function and synaptic plasticity.

E. coli hypoxia-inducible factor ArcA mediates lifespan extension in a lipoic acid synthase mutant by suppressing acetyl-CoA synthetase.

Genome-wide screen identifies Escherichia coli TCA-cycle-related mutants with extended chronological lifespan dependent on acetate metabolism and the hypoxia-inducible transcription factor ArcA.

Endosomal protein sorting and autophagy genes contribute to the regulation of yeast life span.

Linking Klotho, Nrf2, MAP kinases and aging.

Fasting and differential chemotherapy protection in patients.

Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans.

Metabolic alterations in yeast lacking copper-zinc superoxide dismutase.

Lifespan extension and paraquat resistance in a ubiquinone-deficient Escherichia coli mutant depend on transcription factors ArcA and TdcA.

Conserved role of Ras-GEFs in promoting aging: from yeast to mice.

Chronological Aging in Saccharomyces cerevisiae.

Intermittent supplementation with rapamycin as a dietary restriction mimetic.

Fasting Cycles Retard Growth of Tumors and Sensitize a Range of Cancer Cell Types to Chemotherapy.