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School of Biological Sciences,
Institute of Photonics and Advanced Sensing (IPAS),
Institute of Photonics and Advanced Sensing (IPAS), School of Biological Sciences
John B. Bruning has not added Biography.
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Human variants in the neuronal basic helix-loop-helix/Per-Arnt-Sim (bHLH/PAS) transcription factor complex NPAS4/ARNT2 disrupt function.
PloS one , 2014 | Pubmed ID: 24465693
Macrocyclic protease inhibitors with reduced peptide character.
Angewandte Chemie (International ed. in English) Jul, 2014 | Pubmed ID: 24903745
New insights into the evolutionary history of plant sorbitol dehydrogenase.
BMC plant biology Apr, 2015 | Pubmed ID: 25879735
Pharmacological repression of PPARγ promotes osteogenesis.
Nature communications Jun, 2015 | Pubmed ID: 26068133
Structural mechanism for signal transduction in RXR nuclear receptor heterodimers.
Nature communications Aug, 2015 | Pubmed ID: 26289479
Review of the Structural and Dynamic Mechanisms of PPARγ Partial Agonism.
PPAR research , 2015 | Pubmed ID: 26435709
SR2067 Reveals a Unique Kinetic and Structural Signature for PPARγ Partial Agonism.
ACS chemical biology Jan, 2016 | Pubmed ID: 26579553
Structure of the sliding clamp from the fungal pathogen Aspergillus fumigatus (AfumPCNA) and interactions with Human p21.
The FEBS journal 03, 2017 | Pubmed ID: 28165677
Structure-Activity Relationship of 2,4-Dichloro-N-(3,5-dichloro-4-(quinolin-3-yloxy)phenyl)benzenesulfonamide (INT131) Analogs for PPARγ-Targeted Antidiabetics.
Journal of medicinal chemistry 06, 2017 | Pubmed ID: 28485590
X-ray crystal structure of rivoglitazone bound to PPARγ and PPAR subtype selectivity of TZDs.
Biochimica et biophysica acta. General subjects Aug, 2017 | Pubmed ID: 28499821
HDX reveals the conformational dynamics of DNA sequence specific VDR co-activator interactions.
Nature communications 10, 2017 | Pubmed ID: 29030554
Rational Design of a 3 -Helical PIP-Box Mimetic Targeting PCNA, the Human Sliding Clamp.
Chemistry (Weinheim an der Bergstrasse, Germany) Aug, 2018 | Pubmed ID: 29917264
PPARγ in Complex with an Antagonist and Inverse Agonist: a Tumble and Trap Mechanism of the Activation Helix.
iScience Feb, 2018 | Pubmed ID: 30123887
Chemical Crosslinking Mass Spectrometry Reveals the Conformational Landscape of the Activation Helix of PPARγ; a Model for Ligand-Dependent Antagonism.
Structure (London, England : 1993) 11, 2018 | Pubmed ID: 30146169
Precipitant-ligand exchange technique reveals the ADP binding mode in Mycobacterium tuberculosis dethiobiotin synthetase.
Acta crystallographica. Section D, Structural biology Oct, 2018 | Pubmed ID: 30289406
Structure, Mechanism, and Inhibition of Thioredoxin Reductase.
Antimicrobial agents and chemotherapy 03, 2019 | Pubmed ID: 30642940
Shooting three inflammatory targets with a single bullet: Novel multi-targeting anti-inflammatory glitazones.
European journal of medicinal chemistry Apr, 2019 | Pubmed ID: 30818268
Structural and Dynamic Elucidation of a Non-acid PPAR Partial Agonist: SR1988.
Nuclear receptor research , 2018 | Pubmed ID: 30906767
Obtaining Crystals of PPARγ Ligand Binding Domain Bound to Small Molecules.
Methods in molecular biology (Clifton, N.J.) , 2019 | Pubmed ID: 31041754
Combining random microseed matrix screening and the magic triangle for the efficient structure solution of a potential lysin from bacteriophage P68.
Acta crystallographica. Section D, Structural biology Jul, 2019 | Pubmed ID: 31282476
An aldo-keto reductase with 2-keto-l-gulonate reductase activity functions in l-tartaric acid biosynthesis from vitamin C in .
The Journal of biological chemistry 11, 2019 | Pubmed ID: 31488549
d-Alanine-d-alanine ligase as a model for the activation of ATP-grasp enzymes by monovalent cations.
The Journal of biological chemistry 06, 2020 | Pubmed ID: 32335509
Nucleoside selectivity of Aspergillus fumigatus nucleoside-diphosphate kinase.
The FEBS journal Oct, 2020 | Pubmed ID: 33089641
Vanishing white matter: Eukaryotic initiation factor 2B model and the impact of missense mutations.
Molecular genetics & genomic medicine Jan, 2021 | Pubmed ID: 33432707
The University of Adelaide
Jia Quyen Truong*,1,
Stephanie Nguyen*,1,2,
John B. Bruning1,2,
Keith E. Shearwin1
1School of Biological Sciences, The University of Adelaide,
2Institute of Photonics and Advanced Sensing (IPAS), School of Biological Sciences, The University of Adelaide
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