Stephen P. Muench

Cryo-electron microscopy of the vacuolar ATPase motor reveals its mechanical and regulatory complexity.

Identification of T. gondii epitopes, adjuvants, and host genetic factors that influence protection of mice and humans.

Archazolid A binds to the equatorial region of the c-ring of the vacuolar H+-ATPase.

T. gondii RP promoters & knockdown reveal molecular pathways associated with proliferation and cell-cycle arrest.

Structural divergence of the rotary ATPases.

Novel N-benzoyl-2-hydroxybenzamide disrupts unique parasite secretory pathway.

Design, synthesis, and biological activity of diaryl ether inhibitors of Toxoplasma gondii enoyl reductase.

Development of a triclosan scaffold which allows for adaptations on both the A- and B-ring for transport peptides.

Modification of triclosan scaffold in search of improved inhibitors for enoyl-acyl carrier protein (ACP) reductase in Toxoplasma gondii.

Subunit positioning and stator filament stiffness in regulation and power transmission in the V1 motor of the Manduca sexta V-ATPase.

Discrimination of potent inhibitors of Toxoplasma gondii enoyl-acyl carrier protein reductase by a thermal shift assay.

Flexibility within the rotor and stators of the vacuolar H+-ATPase.

The benzimidazole based drugs show good activity against T. gondii but poor activity against its proposed enoyl reductase enzyme target.

ALOX12 in human toxoplasmosis.

PA1b inhibitor binding to subunits c and e of the vacuolar ATPase reveals its insecticidal mechanism.

Non-synonymous single nucleotide polymorphisms in the P2X receptor genes: association with diseases, impact on receptor functions and potential use as diagnosis biomarkers.

Understanding the apparent stator-rotor connections in the rotary ATPase family using coarse-grained computer modeling.

The use of SMALPs as a novel membrane protein scaffold for structure study by negative stain electron microscopy.

The Acanthamoeba shikimate pathway has a unique molecular arrangement and is essential for aromatic amino acid biosynthesis.

Structure of the vacuolar H+-ATPase rotary motor reveals new mechanistic insights.

Replace, reuse, recycle: improving the sustainable use of phosphorus by plants.

Mechanism of inhibition of mouse Slo3 (KCa 5.1) potassium channels by quinine, quinidine and barium.

Docking of competitive inhibitors to the P2X7 receptor family reveals key differences responsible for changes in response between rat and human.

In situ formation of magnetopolymersomes via electroporation for MRI.

Extracellular and Luminal pH Regulation by Vacuolar H+-ATPase Isoform Expression and Targeting to the Plasma Membrane and Endosomes.

An introduction to sample preparation and imaging by cryo-electron microscopy for structural biology.

Methods to account for movement and flexibility in cryo-EM data processing.

Editorial.

Characterization of the flexibility of the peripheral stalk of prokaryotic rotary A-ATPases by atomistic simulations.

Corrigendum to 'Methods to account for movement and flexibility in cryo-EM data processing' [Methods 100 (2016) 35-41].

A method for detergent-free isolation of membrane proteins in their local lipid environment.

Pi sensing and signalling: from prokaryotic to eukaryotic cells.

Rotating with the brakes on and other unresolved features of the vacuolar ATPase.

The varied functions of aluminium-activated malate transporters-much more than aluminium resistance.

Artificial membranes for membrane protein purification, functionality and structure studies.

Structure-based identification and characterisation of structurally novel human P2X7 receptor antagonists.

Durable proteo-hybrid vesicles for the extended functional lifetime of membrane proteins in bionanotechnology.

The changing landscape of membrane protein structural biology through developments in electron microscopy.

The conservation of phosphate-binding residues among PHT1 transporters suggests that distinct transport affinities are unlikely to result from differences in the phosphate-binding site.

Conformational changes during human P2X7 receptor activation examined by structural modelling and cysteine-based cross-linking studies.

Durable vesicles for reconstitution of membrane proteins in biotechnology.

Everyone needs good neighbours - the intricate relationship between the acetylcholine-receptor channel and its membrane environment.

AtSPX1 affects the AtPHR1-DNA-binding equilibrium by binding monomeric AtPHR1 in solution.

Using a SMALP platform to determine a sub-nm single particle cryo-EM membrane protein structure.

A reconstitution method for integral membrane proteins in hybrid lipid-polymer vesicles for enhanced functional durability.

Elucidating the structural basis for differing enzyme inhibitor potency by cryo-EM.

No Longer Hidden Secrets of Proton Pumping: The Resolution Revolution Enlightens V-ATPases.

X-ray and cryo-EM structures of inhibitor-bound cytochrome complexes for structure-based drug discovery.

Approaches to altering particle distributions in cryo-electron microscopy sample preparation.

Cryo-EM structures of complex I from mouse heart mitochondria in two biochemically defined states.

CSGID Solves Structures and Identifies Phenotypes for Five Enzymes in .

Substrate polyspecificity and conformational relevance in ABC transporters: new insights from structural studies.

The expanding toolkit for structural biology: synchrotrons, X-ray lasers and cryoEM.

SMA-PAGE: A new method to examine complexes of membrane proteins using SMALP nano-encapsulation and native gel electrophoresis.

LAT1 (SLC7A5) and CD98hc (SLC3A2) complex dynamics revealed by single-particle cryo-EM.

Emerging Role of Electron Microscopy in Drug Discovery.

Dimeric structures of quinol-dependent nitric oxide reductases (qNORs) revealed by cryo-electron microscopy.

Structural Insight into Eukaryotic Sterol Transport through Niemann-Pick Type C Proteins.

A cryo-EM grid preparation device for time-resolved structural studies.

Styrene maleic acid recovers proteins from mammalian cells and tissues while avoiding significant cell death.

Unprecedented Properties of Phenothiazines Unraveled by a NDH-2 Bioelectrochemical Assay Platform.

Styrene maleic-acid lipid particles (SMALPs) into detergent or amphipols: An exchange protocol for membrane protein characterisation.

Sample deposition onto cryo-EM grids: from sprays to jets and back.

Structure of the protective nematode protease complex H-gal-GP and its conservation across roundworm parasites.

Structure-Based Identification and Characterization of Inhibitors of the Epilepsy-Associated K1.1 (KCNT1) Potassium Channel.

The active form of quinol-dependent nitric oxide reductase from is a dimer.

Cryo-EM Structure and Molecular Dynamics Analysis of the Fluoroquinolone Resistant Mutant of the AcrB Transporter from .

Potent Tetrahydroquinolone Eliminates Apicomplexan Parasites.

Need for Speed: Examining Protein Behavior during CryoEM Grid Preparation at Different Timescales.

Contribution of Val/Ile87 residue in the extracellular domain in agonist-induced current responses of the human and rat P2X7 receptors.

Human TRPC5 structures reveal interaction of a xanthine-based TRPC1/4/5 inhibitor with a conserved lipid binding site.

Structural Basis for Vascular Endothelial Growth Factor Receptor Activation and Implications for Disease Therapy.

Cryo-EM structure of human mitochondrial HSPD1.

Structure of the endocytic adaptor complex reveals the basis for efficient membrane anchoring during clathrin-mediated endocytosis.

Targeting K1.1 channels in KCNT1-associated epilepsy.

On-grid and in-flow mixing for time-resolved cryo-EM.

Tyrosine 288 in the extracellular domain of the human P2X7 receptor is critical for receptor function revealed by structural modeling and site-directed mutagenesis.