Stephen Dewhurst

Expression of human immunodeficiency virus type 1 gp120 from herpes simplex virus type 1-derived amplicons results in potent, specific, and durable cellular and humoral immune responses.

Tumor necrosis factor-alpha in normal and diseased brain: Conflicting effects via intraneuronal receptor crosstalk?

Engineered fibronectin type III domain with a RGDWXE sequence binds with enhanced affinity and specificity to human alphavbeta3 integrin.

Mechanistic understanding of an altered fidelity simian immunodeficiency virus reverse transcriptase mutation, V148I, identified in a pig-tailed macaque.

Cellular immune responses to helper-free HSV-1 amplicon particles encoding HIV-1 gp120 are enhanced by DNA priming.

A peptide containing a novel FPGN CD40-binding sequence enhances adenoviral infection of murine and human dendritic cells.

Murine cytomegalovirus abortively infects human dendritic cells, leading to expression and presentation of virally vectored genes.

Effects of codon-optimization on protein expression by the human herpesvirus 6 and 7 U51 open reading frame.

Neuroprotective activities of sodium valproate in a murine model of human immunodeficiency virus-1 encephalitis.

Immunohistochemical assessment of fractalkine, inflammatory cells, and human herpesvirus 7 in human salivary glands.

Transient overexpression of kappa and mu opioid receptors using recombinant adenovirus vectors.

Activation of adenosine A2A receptor protects sympathetic neurons against nerve growth factor withdrawal.

Human herpesvirus type 6 and human herpesvirus type 7 infections of the central nervous system.

Macrophage tropism of HIV-1 depends on efficient cellular dNTP utilization by reverse transcriptase.

Congenital infections with human herpesvirus 6 (HHV6) and human herpesvirus 7 (HHV7).

Human herpesvirus 6 (HHV6) DNA persistence and reactivation in healthy children.

False memories in children. Evidence for a shift from phonological to semantic associations.

Dishevelled promotes neurite outgrowth in neuronal differentiating neuroblastoma 2A cells, via a DIX-domain dependent pathway.

Inhibition of HIV type 1 replication using lentiviral-mediated delivery of mutant tRNA(Lys3)A58U.

Human dendritic cells transduced with herpes simplex virus amplicons encoding human immunodeficiency virus type 1 (HIV-1) gp120 elicit adaptive immune responses from human cells engrafted into NOD/SCID mice and confer partial protection against HIV-1 challenge.

Valproic acid enhances gene expression from viral gene transfer vectors.

Opposite effects of lithium and valproic acid on trophic factor deprivation-induced glycogen synthase kinase-3 activation, c-Jun expression and neuronal cell death.

HIV-1 transactivator of transcription protein induces mitochondrial hyperpolarization and synaptic stress leading to apoptosis.

Intention to learn influences the word frequency effect in recall but not in recognition memory.

Measuring the speed of the conscious components of recognition memory: remembering is faster than knowing.

The human herpesvirus 6 G protein-coupled receptor homolog U51 positively regulates virus replication and enhances cell-cell fusion in vitro.

HIV-1-based defective lentiviral vectors efficiently transduce human monocytes-derived macrophages and suppress replication of wild-type HIV-1.

Recombinant adenovirus type 5 vectors that target DC-SIGN, ChemR23 and alpha(v)beta3 integrin efficiently transduce human dendritic cells and enhance presentation of vectored antigens.

Neuroprotective mechanisms of lithium in murine human immunodeficiency virus-1 encephalitis.

A simple method for displaying recalcitrant proteins on the surface of bacteriophage lambda.

Selective interference with the use of visual images in the symbolic distance paradigm.

Characteristics and acquisition of human herpesvirus (HHV) 7 infections in relation to infection with HHV-6.

Distinctiveness, typicality, and recollective experience in face recognition: a principal components analysis.

Inhibition of mixed lineage kinase 3 prevents HIV-1 Tat-mediated neurotoxicity and monocyte activation.

Amplicons as vaccine vectors.

Human immunodeficiency virus-encoded Tat activates glycogen synthase kinase-3beta to antagonize nuclear factor-kappaB survival pathway in neurons.

Dissociating word frequency and age of acquisition: The Klein effect revived (and reversed).

Effect of promoter strength on protein expression and immunogenicity of an HSV-1 amplicon vector encoding HIV-1 Gag.

Infection of human immunodeficiency virus and intracellular viral Tat protein exert a pro-survival effect in a human microglial cell line.

Human immunodeficiency virus type 1 pathobiology studied in humanized BALB/c-Rag2-/-gammac-/- mice.

Human papillomavirus-like particles mediate functional delivery of plasmid DNA to antigen presenting cells in vivo.

Spatial and temporal expression of herpes simplex virus type 1 amplicon-encoded genes: implications for their use as immunization vectors.

Functional synergy between CD40 ligand and HIV-1 Tat contributes to inflammation: implications in HIV type 1 dementia.

A tractable method for simultaneous modifications to the head and tail of bacteriophage lambda and its application to enhancing phage-mediated gene delivery.

Story contexts increase susceptibility to the DRM illusion in 5-year-olds.

Reinstating effortful encoding operations at test enhances episodic remembering.

Infectivity of herpes simplex virus type-1 (HSV-1) amplicon vectors in dendritic cells is determined by the helper virus strain used for packaging.

Divided attention at retrieval disrupts knowing but not remembering.

The effect of divided attention on false memory depends on how memory is tested.

HSV-1 amplicon vectors elicit polyfunctional T cell responses to HIV-1 Env, and strongly boost responses to an adenovirus prime.

The effect of glucose administration on the recollection and familiarity components of recognition memory.

Enhanced transduction of dendritic cells by FcgammaRI-targeted adenovirus vectors.

Glycogen synthase kinase 3 beta (GSK-3 beta) as a therapeutic target in neuroAIDS.

Sequential shrinkage and swelling underlie P2X7-stimulated lymphocyte phosphatidylserine exposure and death.

Fc receptor-mediated, antibody-dependent enhancement of bacteriophage lambda-mediated gene transfer in mammalian cells.

Akt inhibitors as an HIV-1 infected macrophage-specific anti-viral therapy.

The effects of divided attention at study and test on false recognition: a comparison of DRM and categorized lists.

Dynamic visual noise interferes with storage in visual working memory.

The human H5N1 influenza A virus polymerase complex is active in vitro over a broad range of temperatures, in contrast to the WSN complex, and this property can be attributed to the PB2 subunit.

HIV-1 Tat activates neuronal ryanodine receptors with rapid induction of the unfolded protein response and mitochondrial hyperpolarization.

False and veridical collaborative recognition.

Proteasome inhibitors enhance bacteriophage lambda (lambda) mediated gene transfer in mammalian cells.

Remembering the past and imagining the future: differences in event specificity of spontaneously generated thought.

Lithium therapy for human immunodeficiency virus type 1-associated neurocognitive impairment.

Nef gene evolution from a single transmitted strain in acute SIV infection.

The mechanistic architecture of thermostable Pyrococcus furiosus family B DNA polymerase motif A and its interaction with the dNTP substrate.

Neuroprotective activities of CEP-1347 in models of neuroAIDS.

Mixed Lineage Kinase 3 deficiency delays viral clearance in the lung and is associated with diminished influenza-induced cytopathic effect in infected cells.

Mathematical modeling of ultradeep sequencing data reveals that acute CD8+ T-lymphocyte responses exert strong selective pressure in simian immunodeficiency virus-infected macaques but still fail to clear founder epitope sequences.

Biochemical characterization of enzyme fidelity of influenza A virus RNA polymerase complex.

CD8+ cell depletion accelerates HIV-1 immunopathology in humanized mice.

Can false memories prime problem solutions?

Amyloid-binding small molecules efficiently block SEVI (semen-derived enhancer of virus infection)- and semen-mediated enhancement of HIV-1 infection.

Rebuilding synaptic architecture in HIV-1 associated neurocognitive disease: a therapeutic strategy based on modulation of mixed lineage kinase.

Ablation of mixed lineage kinase 3 (Mlk3) does not inhibit ototoxicity induced by acoustic trauma or aminoglycoside exposure.

Methamphetamine causes sustained depression in cerebral blood flow.

Investigating the encoding-retrieval match in recognition memory: effects of experimental design, specificity, and retention interval.

Dense display of HIV-1 envelope spikes on the lambda phage scaffold does not result in the generation of improved antibody responses to HIV-1 Env.

The development of automatic and controlled inhibitory retrieval processes in true and false recall.

Enhancement of HIV-1 infectivity by simple, self-assembling modular peptides.

A gender difference in the false recall of negative words: women DRM more than men.

Test-induced priming impairs source monitoring accuracy in the DRM procedure.

PA residues in the 2009 H1N1 pandemic influenza virus enhance avian influenza virus polymerase activity in mammalian cells.

Dazed and confused by HHV-6.

Lentiviral vector-mediated stable expression of sTNFR-Fc in human macrophage and neuronal cells as a potential therapy for neuroAIDS.

Comprehensive proteomic analysis of influenza virus polymerase complex reveals a novel association with mitochondrial proteins and RNA polymerase accessory factors.

Robust antigen-specific humoral immune responses to sublingually delivered adenoviral vectors encoding HIV-1 Env: association with mucoadhesion and efficient penetration of the sublingual barrier.

Biochemical impact of the host adaptation-associated PB2 E627K mutation on the temperature-dependent RNA synthesis kinetics of influenza A virus polymerase complex.

What factors underlie associative and categorical memory illusions? The roles of backward associative strength and interitem connectivity.

Test-induced priming increases false recognition in older but not younger children.

HIV-1 Tat-induced microgliosis and synaptic damage via interactions between peripheral and central myeloid cells.

Shared cognitive processes underlying past and future thinking: The impact of imagery and concurrent task demands on event specificity.

Advances in HIV microbicide development.

Adenoviral vector driven by a minimal Rad51 promoter is selective for p53-deficient tumor cells.

Oligovalent Amyloid-Binding Agents Reduce SEVI-Mediated Enhancement of HIV-1 Infection.

Seminal plasma accelerates semen-derived enhancer of viral infection (SEVI) fibril formation by the prostatic acid phosphatase (PAP248-286) peptide.

9G4 autoreactivity is increased in HIV-infected patients and correlates with HIV broadly neutralizing serum activity.

Selective modification of adenovirus replication can be achieved through rational mutagenesis of the adenovirus type 5 DNA polymerase.

Transient hypercapnia reveals an underlying cerebrovascular pathology in a murine model for HIV-1 associated neuroinflammation: role of NO-cGMP signaling and normalization by inhibition of cyclic nucleotide phosphodiesterase-5.

Anti-idiotypic monobodies derived from a fibronectin scaffold.

Semen-derived enhancer of viral infection (SEVI) binds bacteria, enhances bacterial phagocytosis by macrophages, and can protect against vaginal infection by a sexually transmitted bacterial pathogen.

Nanoparticle-mediated gene silencing confers radioprotection to salivary glands in vivo.

Directional Histogram Ratio at Random Probes: A Local Thresholding Criterion for Capillary Images.

Pharmacokinetic interactions of CEP-1347 and atazanavir in HIV-infected patients.

The new small-molecule mixed-lineage kinase 3 inhibitor URMC-099 is neuroprotective and anti-inflammatory in models of human immunodeficiency virus-associated neurocognitive disorders.

Fluorescence detection of cationic amyloid fibrils in human semen.

Discovery, synthesis, and characterization of an orally bioavailable, brain penetrant inhibitor of mixed lineage kinase 3.

Classification of HHV-6A and HHV-6B as distinct viruses.

Poor Aerobic Fitness May Contribute to Cognitive Decline in HIV-infected Older Adults.

Use of bacteriophage particles displaying influenza virus hemagglutinin for the detection of hemagglutination-inhibition antibodies.

9G4+ antibodies isolated from HIV-infected patients neutralize HIV-1 and have distinct autoreactivity profiles.

MLK3 regulates fMLP-stimulated neutrophil motility.

What factors underlie children's susceptibility to semantic and phonological false memories? investigating the roles of language skills and auditory short-term memory.

Chronic central nervous system expression of HIV-1 Tat leads to accelerated rarefaction of neocortical capillaries and loss of red blood cell velocity heterogeneity.

Theoretical model of critical issues in informed consent in HIV vaccine trials.

Influenza A virus attenuation by codon deoptimization of the NS gene for vaccine development.

Ganciclovir inhibits human adenovirus replication and pathogenicity in permissive immunosuppressed Syrian hamsters.

Pharmacologic inhibition of MLK3 kinase activity blocks the in vitro migratory capacity of breast cancer cells but has no effect on breast cancer brain metastasis in a mouse xenograft model.

Development of a mouse-adapted live attenuated influenza virus that permits in vivo analysis of enhancements to the safety of live attenuated influenza virus vaccine.

Episodic elaboration: Investigating the structure of retrieved past events and imagined future events.

Inhibition of the enhancement of infection of human immunodeficiency virus by semen-derived enhancer of virus infection using amyloid-targeting polymeric nanoparticles.

Leucine-rich repeat kinase 2 modulates neuroinflammation and neurotoxicity in models of human immunodeficiency virus 1-associated neurocognitive disorders.

Eyewitness memory: The impact of a negative mood during encoding and/or retrieval upon recall of a non-emotive event.

A dysphoric's TALE: The relationship between the self-reported functions of autobiographical memory and symptoms of depression.

Neomycin Sulfate Improves the Antimicrobial Activity of Mupirocin-based Antibacterial Ointments.

A single mutation at PB1 residue 319 dramatically increases the safety of PR8 LAIV in a murine model without compromising vaccine efficacy.