Department of Bioengineering,
Barnett Institute,
Department of Biology
Nikolai Slavov is an Allen Distinguished Investigator and associate professor at Northeastern University in the Bioengineering Department and Barnett Institute. His lab has pioneered several multiplexed experimental methods for quantifying proteins in single cells and is developing new computational methods for analyzing and understanding single-cell protein data. He organizes the annual single-cell proteomics conference (single-cell.net/) and contributes to organizing other leading conferences, including HUPO, Oxford Global, NeurIPS, and others. The Slavov lab obtained direct evidence for a new regulatory mechanism of protein synthesis (ribosome specialization) and continues to drive research in this emerging field. Research from the Slavov lab has been recognized and supported by many prestigious awards, including the Allen Distinguished Investigator Award, the NIH Director’s Award, the Chan Zuckerberg Initiative, and iAward from Sanofi. Nikolai Slavov received BS from MIT in 2004, a PhD from Princeton University (Botstein laboratory) in 2010 and conducted postdoctoral research in the van Oudenaarden laboratory at MIT.
Voices in methods development.
Nature methods Oct, 2019 | Pubmed ID: 31562479
Making the most of peer review.
eLife Nov, 2015 | Pubmed ID: 26559758
Differential Stoichiometry among Core Ribosomal Proteins.
Cell reports Nov, 2015 | Pubmed ID: 26565899
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Autophagy Jan, 2016 | Pubmed ID: 26799652
Comparative Proteomic Profiling of Divergent Phenotypes for Water Holding Capacity across the Post Mortem Ageing Period in Porcine Muscle Exudate.
PloS one , 2016 | Pubmed ID: 26950297
Kinase Activities of RIPK1 and RIPK3 Can Direct IFN-β Synthesis Induced by Lipopolysaccharide.
Journal of immunology (Baltimore, Md. : 1950) 06, 2017 | Pubmed ID: 28461567
Post-transcriptional regulation across human tissues.
PLoS computational biology May, 2017 | Pubmed ID: 28481885
Transformative Opportunities for Single-Cell Proteomics.
Journal of proteome research Aug, 2018 | Pubmed ID: 29945450
Single cell protein analysis for systems biology.
Essays in biochemistry Oct, 2018 | Pubmed ID: 30072488
Quantifying Homologous Proteins and Proteoforms.
Molecular & cellular proteomics : MCP Jan, 2019 | Pubmed ID: 30282776
SCoPE-MS: mass spectrometry of single mammalian cells quantifies proteome heterogeneity during cell differentiation.
Genome biology Oct, 2018 | Pubmed ID: 30343672
Ribosome Stoichiometry: From Form to Function.
Trends in biochemical sciences Feb, 2019 | Pubmed ID: 30473427
Approaches for Studying Ribosome Specialization.
Trends in biochemical sciences May, 2019 | Pubmed ID: 30792028
DO-MS: Data-Driven Optimization of Mass Spectrometry Methods.
Journal of proteome research Jun, 2019 | Pubmed ID: 31081635
DART-ID increases single-cell proteome coverage.
PLoS computational biology Jul, 2019 | Pubmed ID: 31260443
Unpicking the proteome in single cells.
Science (New York, N.Y.) Jan, 2020 | Pubmed ID: 32001644
Single-cell protein analysis by mass spectrometry.
Current opinion in chemical biology Feb, 2021 | Pubmed ID: 32599342
Analyzing Ribosome Remodeling in Health and Disease.
Proteomics Sep, 2020 | Pubmed ID: 32820594
Optimizing Accuracy and Depth of Protein Quantification in Experiments Using Isobaric Carriers.
Journal of proteome research Jan, 2021 | Pubmed ID: 33190502
Single-cell proteomic and transcriptomic analysis of macrophage heterogeneity using SCoPE2.
Genome biology Jan, 2021 | Pubmed ID: 33504367
Voices of biotech research.
Nature biotechnology Mar, 2021 | Pubmed ID: 33692517
Increasing proteomics throughput.
Nature biotechnology Jul, 2021 | Pubmed ID: 33767394
Measuring Protein Shapes in Living Cells.
Journal of proteome research Jun, 2021 | Pubmed ID: 33988997
Driving Single Cell Proteomics Forward with Innovation.
Journal of proteome research Nov, 2021 | Pubmed ID: 34597050
Multiplexed single-cell proteomics using SCoPE2.
Nature protocols Dec, 2021 | Pubmed ID: 34716448
Global characterization of macrophage polarization mechanisms and identification of M2-type polarization inhibitors.
Cell reports Nov, 2021 | Pubmed ID: 34731634
Comprehensive Identification of Regulatory Protein Networks.
Journal of proteome research Nov, 2021 | Pubmed ID: 34736325
Scaling Up Single-Cell Proteomics.
Molecular & cellular proteomics : MCP Jan, 2022 | Pubmed ID: 34808355
Learning from natural variation across the proteomes of single cells.
PLoS biology Jan, 2022 | Pubmed ID: 34986167
Counting protein molecules for single-cell proteomics.
Cell Jan, 2022 | Pubmed ID: 35063071
Beyond Protein Sequence: Protein Isomerization in Alzheimer's Disease.
Journal of proteome research Feb, 2022 | Pubmed ID: 35114789
New Views of Old Proteins: Clarifying the Enigmatic Proteome.
Molecular & cellular proteomics : MCP Jul, 2022 | Pubmed ID: 35654359
Increasing the throughput of sensitive proteomics by plexDIA.
Nature biotechnology Jul, 2022 | Pubmed ID: 35835881
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