Department of Development and Regeneration,
Stem Cell Institute Leuven (SCIL),
Department of Development and Regeneration, Stem Cell Institute Leuven (SCIL)
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Human pluripotent stem cell-derived hepatocytes support complete replication of hepatitis C virus.
Journal of hepatology Aug, 2012 | Pubmed ID: 22521345
Antagonism of Nodal signaling by BMP/Smad5 prevents ectopic primitive streak formation in the mouse amnion.
Development (Cambridge, England) Sep, 2012 | Pubmed ID: 22912414
Neural differentiation and support of neuroregeneration of non-neural adult stem cells.
Progress in brain research , 2012 | Pubmed ID: 23186708
A novel role of BMP4 in adult hematopoietic stem and progenitor cell homing via Smad independent regulation of integrin-α4 expression.
Blood Jan, 2013 | Pubmed ID: 23243277
Immunological characteristics of human mesenchymal stem cells and multipotent adult progenitor cells.
Immunology and cell biology Jan, 2013 | Pubmed ID: 23295415
Glypican-3-mediated inhibition of CD26 by TFPI: a novel mechanism in hematopoietic stem cell homing and maintenance.
Blood Apr, 2013 | Pubmed ID: 23327927
COUP-TFII orchestrates venous and lymphatic endothelial identity by homo- or hetero-dimerisation with PROX1.
Journal of cell science Mar, 2013 | Pubmed ID: 23345397
18F-FDG labeling of mesenchymal stem cells and multipotent adult progenitor cells for PET imaging: effects on ultrastructure and differentiation capacity.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine Mar, 2013 | Pubmed ID: 23353687
Self-renewal of neural stem cells: implications for future therapies.
Frontiers in physiology , 2013 | Pubmed ID: 23513073
Mutual interaction between human multipotent adult progenitor cells and NK cells.
Cell transplantation , 2014 | Pubmed ID: 23562064
Mesenchymal stem cells migration homing and tracking.
Stem cells international , 2013 | Pubmed ID: 24194766
Biliary cells to the rescue of Prometheus.
Gastroenterology Mar, 2014 | Pubmed ID: 24462990
Hepatic differentiation of human embryonic stem cells on microcarriers.
Journal of biotechnology Mar, 2014 | Pubmed ID: 24480567
Prospectively isolated NGN3-expressing progenitors from human embryonic stem cells give rise to pancreatic endocrine cells.
Stem cells translational medicine Apr, 2014 | Pubmed ID: 24493854
MicroRNAs: the fine modulators of liver development and function.
Liver international : official journal of the International Association for the Study of the Liver Aug, 2014 | Pubmed ID: 24517588
Optimization of multimodal imaging of mesenchymal stem cells using the human sodium iodide symporter for PET and Cerenkov luminescence imaging.
PloS one , 2014 | Pubmed ID: 24747914
SMAD signaling regulates CXCL12 expression in the bone marrow niche, affecting homing and mobilization of hematopoietic progenitors.
Stem cells (Dayton, Ohio) Nov, 2014 | Pubmed ID: 25069965
FANCA knockout in human embryonic stem cells causes a severe growth disadvantage.
Stem cell research Sep, 2014 | Pubmed ID: 25108529
Controlling and monitoring stem cell safety in vivo in an experimental rodent model.
Stem cells (Dayton, Ohio) Nov, 2014 | Pubmed ID: 25142614
Radiolabeling strategies for radionuclide imaging of stem cells.
Stem cell reviews Apr, 2015 | Pubmed ID: 25534590
Restoration of progranulin expression rescues cortical neuron generation in an induced pluripotent stem cell model of frontotemporal dementia.
Stem cell reports Jan, 2015 | Pubmed ID: 25556567
Contribution of different bone marrow-derived cell types in endometrial regeneration using an irradiated murine model.
Fertility and sterility Jun, 2015 | Pubmed ID: 25813284
Assessment of bystander killing-mediated therapy of malignant brain tumors using a multimodal imaging approach.
Stem cell research & therapy Sep, 2015 | Pubmed ID: 26345383
Altered neuronal network and rescue in a human MECP2 duplication model.
Molecular psychiatry Feb, 2016 | Pubmed ID: 26347316
Efficient Recombinase-Mediated Cassette Exchange in hPSCs to Study the Hepatocyte Lineage Reveals AAVS1 Locus-Mediated Transgene Inhibition.
Stem cell reports Nov, 2015 | Pubmed ID: 26455413
Mesodermal iPSC-derived progenitor cells functionally regenerate cardiac and skeletal muscle.
The Journal of clinical investigation Dec, 2015 | Pubmed ID: 26571398
Highly proliferative primitive fetal liver hematopoietic stem cells are fueled by oxidative metabolic pathways.
Stem cell research Nov, 2015 | Pubmed ID: 26599326
Sodium Iodide Symporter PET and BLI Noninvasively Reveal Mesoangioblast Survival in Dystrophic Mice.
Stem cell reports Dec, 2015 | Pubmed ID: 26626179
Stem cell-derived hepatocytes: A novel model for hepatitis E virus replication.
Journal of hepatology Mar, 2016 | Pubmed ID: 26626494
Monitoring the Bystander Killing Effect of Human Multipotent Stem Cells for Treatment of Malignant Brain Tumors.
Stem cells international , 2016 | Pubmed ID: 26880961
In Vivo Interleukin-13-Primed Macrophages Contribute to Reduced Alloantigen-Specific T Cell Activation and Prolong Immunological Survival of Allogeneic Mesenchymal Stem Cell Implants.
Stem cells (Dayton, Ohio) 07, 2016 | Pubmed ID: 26992046
Increased Understanding of Stem Cell Behavior in Neurodegenerative and Neuromuscular Disorders by Use of Noninvasive Cell Imaging.
Stem cells international , 2016 | Pubmed ID: 26997958
Neovascularization Potential of Blood Outgrowth Endothelial Cells From Patients With Stable Ischemic Heart Failure Is Preserved.
Journal of the American Heart Association Apr, 2016 | Pubmed ID: 27091182
Pancreatic differentiation of Pdx1-GFP reporter mouse induced pluripotent stem cells.
Differentiation; research in biological diversity 12, 2016 | Pubmed ID: 27181524
Epigenetic Induction of Definitive and Pancreatic Endoderm Cell Fate in Human Fibroblasts.
Stem cells international , 2016 | Pubmed ID: 27403168
Clinical-Grade Human Multipotent Adult Progenitor Cells Block CD8+ Cytotoxic T Lymphocytes.
Stem cells translational medicine Jul, 2016 | Pubmed ID: 27465071
H3K27me3 Does Not Orchestrate the Expression of Lineage-Specific Markers in hESC-Derived Hepatocytes In Vitro.
Stem cell reports Aug, 2016 | Pubmed ID: 27477635
Cell Expansion During Directed Differentiation of Stem Cells Toward the Hepatic Lineage.
Stem cells and development 02, 2017 | Pubmed ID: 27806669
De novo design of a biologically active amyloid.
Science (New York, N.Y.) 11, 2016 | Pubmed ID: 27846578
Dual loss of succinate dehydrogenase (SDH) and complex I activity is necessary to recapitulate the metabolic phenotype of SDH mutant tumors.
Metabolic engineering 09, 2017 | Pubmed ID: 27847310
Outside-in integrin signalling regulates haematopoietic stem cell function via Periostin-Itgav axis.
Nature communications 12, 2016 | Pubmed ID: 27905395
Distinct Molecular Signature of Murine Fetal Liver and Adult Hematopoietic Stem Cells Identify Novel Regulators of Hematopoietic Stem Cell Function.
Stem cells and development 04, 2017 | Pubmed ID: 27958775
PDGFRα Cells in Embryonic Stem Cell Cultures Represent the In Vitro Equivalent of the Pre-implantation Primitive Endoderm Precursors.
Stem cell reports 02, 2017 | Pubmed ID: 28089671
Epithelial organoid cultures from patients with ulcerative colitis and Crohn's disease: a truly long-term model to study the molecular basis for inflammatory bowel disease?
Gut 12, 2017 | Pubmed ID: 28159838
Activin A Modulates CRIPTO-1/HNF4 Cells to Guide Cardiac Differentiation from Human Embryonic Stem Cells.
Stem cells international , 2017 | Pubmed ID: 28163723
Hmga2 translocation induced in skin tumorigenesis.
Oncotarget May, 2017 | Pubmed ID: 28415789
Proline metabolism supports metastasis formation and could be inhibited to selectively target metastasizing cancer cells.
Nature communications 05, 2017 | Pubmed ID: 28492237
Multipotent adult progenitor cells improve the hematopoietic function in myelodysplasia.
Cytotherapy 06, 2017 | Pubmed ID: 28499585
Molecular Imaging of Human Embryonic Stem Cells Stably Expressing Human PET Reporter Genes After Zinc Finger Nuclease-Mediated Genome Editing.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 10, 2017 | Pubmed ID: 28596158
Immunoregulatory effects of multipotent adult progenitor cells in a porcine ex vivo lung perfusion model.
Stem cell research & therapy Jul, 2017 | Pubmed ID: 28676074
Replication of the Zika virus in different iPSC-derived neuronal cells and implications to assess efficacy of antivirals.
Antiviral research Sep, 2017 | Pubmed ID: 28736077
HDAC6 inhibition reverses axonal transport defects in motor neurons derived from FUS-ALS patients.
Nature communications 10, 2017 | Pubmed ID: 29021520
Dynamic regulation of EZH2 from HPSc to hepatocyte-like cell fate.
PloS one , 2017 | Pubmed ID: 29091973
Human intestinal epithelium in a dish: Current models for research into gastrointestinal pathophysiology.
United European gastroenterology journal Dec, 2017 | Pubmed ID: 29238585
SOX10 Single Transcription Factor-Based Fast and Efficient Generation of Oligodendrocytes from Human Pluripotent Stem Cells.
Stem cell reports 02, 2018 | Pubmed ID: 29337119
Generating tissue-resident macrophages from pluripotent stem cells: Lessons learned from microglia.
Cellular immunology 08, 2018 | Pubmed ID: 29433896
Folic Acid Exposure Rescues Spina Bifida Aperta Phenotypes in Human Induced Pluripotent Stem Cell Model.
Scientific reports 02, 2018 | Pubmed ID: 29440666
PFN2 and GAMT as common molecular determinants of axonal Charcot-Marie-Tooth disease.
Journal of neurology, neurosurgery, and psychiatry 08, 2018 | Pubmed ID: 29449460
Multipotent Adult Progenitor Cells Support Lymphatic Regeneration at Multiple Anatomical Levels during Wound Healing and Lymphedema.
Scientific reports 03, 2018 | Pubmed ID: 29497054
Recent advances in lineage differentiation from stem cells: hurdles and opportunities?
F1000Research , 2018 | Pubmed ID: 29552337
Strategies for In Vivo Genome Editing in Nondividing Cells.
Trends in biotechnology 08, 2018 | Pubmed ID: 29685818
Generation of hepatocyte- and endocrine pancreatic-like cells from human induced endodermal progenitor cells.
PloS one , 2018 | Pubmed ID: 29750821
The human somatostatin receptor type 2 as an imaging and suicide reporter gene for pluripotent stem cell-derived therapy of myocardial infarction.
Theranostics , 2018 | Pubmed ID: 29774076
In Vitro Pluripotent Stem Cell Differentiation to Hepatocyte Ceases Further Maturation at an Equivalent Stage of E15 in Mouse Embryonic Liver Development.
Stem cells and development 07, 2018 | Pubmed ID: 29851366
Energy Producing Metabolic Pathways in Functional Regulation of the Hematopoietic Stem Cells.
IUBMB life 07, 2018 | Pubmed ID: 29999238
Generation of a human induced pluripotent stem cell-based model for tauopathies combining three microtubule-associated protein TAU mutations which displays several phenotypes linked to neurodegeneration.
Alzheimer's & dementia : the journal of the Alzheimer's Association 10, 2018 | Pubmed ID: 30036493
Generation of Hepatic Stellate Cells from Human Pluripotent Stem Cells Enables In Vitro Modeling of Liver Fibrosis.
Cell stem cell Jul, 2018 | Pubmed ID: 30049452
Human stem cell-derived monocytes and microglia-like cells reveal impaired amyloid plaque clearance upon heterozygous or homozygous loss of TREM2.
Alzheimer's & dementia : the journal of the Alzheimer's Association 03, 2019 | Pubmed ID: 30442540
The Impact of Integrin β2 on Granulocyte/Macrophage Progenitor Proliferation.
Stem cells (Dayton, Ohio) 03, 2019 | Pubmed ID: 30537419
Human stem cell-derived hepatocyte-like cells support Zika virus replication and provide a relevant model to assess the efficacy of potential antivirals.
PloS one , 2018 | Pubmed ID: 30566505
Evidence for an alternative fatty acid desaturation pathway increasing cancer plasticity.
Nature 02, 2019 | Pubmed ID: 30728499
Breast cancer cells rely on environmental pyruvate to shape the metastatic niche.
Nature 04, 2019 | Pubmed ID: 30814728
Prdm12 Directs Nociceptive Sensory Neuron Development by Regulating the Expression of the NGF Receptor TrkA.
Cell reports 03, 2019 | Pubmed ID: 30917309
Dystrophin deficiency leads to dysfunctional glutamate clearance in iPSC derived astrocytes.
Translational psychiatry 08, 2019 | Pubmed ID: 31434868
Carfilzomib-induced reticulocytosis in patients with multiple myeloma is caused by impaired terminal erythroid maturation.
Leukemia 02, 2020 | Pubmed ID: 31467428
Differentiation but not ALS mutations in FUS rewires motor neuron metabolism.
Nature communications , | Pubmed ID: 31515480
Stem-cell-derived human microglia transplanted in mouse brain to study human disease.
Nature neuroscience 12, 2019 | Pubmed ID: 31659342
Integrative and perturbation-based analysis of the transcriptional dynamics of TGFβ/BMP system components in transition from embryonic stem cells to neural progenitors.
Stem cells (Dayton, Ohio) 02, 2020 | Pubmed ID: 31675135
Inflammation-associated suppression of metabolic gene networks in acute and chronic liver disease.
Archives of toxicology Jan, 2020 | Pubmed ID: 31919559
Functional expression and pharmacological modulation of TRPM3 in human sensory neurons.
British journal of pharmacology Jun, 2020 | Pubmed ID: 31985045
Unraveling the transcriptional determinants of liver sinusoidal endothelial cell specialization.
American journal of physiology. Gastrointestinal and liver physiology 04, 2020 | Pubmed ID: 32116021
Alternative Cell Sources for Liver Parenchyma Repopulation: Where Do We Stand?
Cells 02, 2020 | Pubmed ID: 32121068
Amino acid levels determine metabolism and CYP450 function of hepatocytes and hepatoma cell lines.
Nature communications 03, 2020 | Pubmed ID: 32170132
Corrigendum to "FANCA knockout in human embryonic stem cells causes a severe growth disadvantage" [Stem Cell Res.13/2 (2014) 240-50].
Stem cell research 04, 2020 | Pubmed ID: 32199280
Ex Vivo Mimicking of Inflammation in Organoids Derived From Patients With Ulcerative Colitis.
Gastroenterology 10, 2020 | Pubmed ID: 32474118
Gene editing technology for improving life quality: A dream coming true?
Clinical genetics 01, 2021 | Pubmed ID: 32506418
The EU-ToxRisk method documentation, data processing and chemical testing pipeline for the regulatory use of new approach methods.
Archives of toxicology 07, 2020 | Pubmed ID: 32632539
The Periostin/Integrin-αv Axis Regulates the Size of Hematopoietic Stem Cell Pool in the Fetal Liver.
Stem cell reports 08, 2020 | Pubmed ID: 32735820
Correction of CFTR function in intestinal organoids to guide treatment of cystic fibrosis.
The European respiratory journal 01, 2021 | Pubmed ID: 32747394
Towards Mimicking the Fetal Liver Niche: The Influence of Elasticity and Oxygen Tension on Hematopoietic Stem/Progenitor Cells Cultured in 3D Fibrin Hydrogels.
International journal of molecular sciences Sep, 2020 | Pubmed ID: 32887387
Generation of oligodendrocytes and establishment of an all-human myelinating platform from human pluripotent stem cells.
Nature protocols 11, 2020 | Pubmed ID: 33097924
Comparing in vitro human liver models to in vivo human liver using RNA-Seq.
Archives of toxicology 02, 2021 | Pubmed ID: 33106934
Therapeutic modalities and novel approaches in regenerative medicine for COVID-19.
International journal of antimicrobial agents Dec, 2020 | Pubmed ID: 33213829
PU.1 drives specification of pluripotent stem cell-derived endothelial cells to LSEC-like cells.
Cell death & disease 01, 2021 | Pubmed ID: 33446637
Systematic transcriptome-based comparison of cellular adaptive stress response activation networks in hepatic stem cell-derived progeny and primary human hepatocytes.
Toxicology in vitro : an international journal published in association with BIBRA Jun, 2021 | Pubmed ID: 33545341
Niche-Mediated Integrin Signaling Supports Steady-State Hematopoiesis in the Spleen.
Journal of immunology (Baltimore, Md. : 1950) 04, 2021 | Pubmed ID: 33637617
HDAC6 inhibition restores TDP-43 pathology and axonal transport defects in human motor neurons with TARDBP mutations.
The EMBO journal Apr, 2021 | Pubmed ID: 33694180
-derived arginine-containing dipeptide repeats associate with axonal transport machinery and impede microtubule-based motility.
Science advances Apr, 2021 | Pubmed ID: 33837088
Rectal organoid morphology analysis (ROMA) as a promising diagnostic tool in cystic fibrosis.
Thorax 11, 2021 | Pubmed ID: 33859053
Directed differentiation of human induced pluripotent stem cells to hepatic stellate cells.
Nature protocols 05, 2021 | Pubmed ID: 33864055
SOX9-induced Generation of Functional Astrocytes Supporting Neuronal Maturation in an All-human System.
Stem cell reviews and reports 10, 2021 | Pubmed ID: 33982246
Actuation enhances patterning in human neural tube organoids.
Nature communications 05, 2021 | Pubmed ID: 34045434
A fully defined matrix to support a pluripotent stem cell derived multi-cell-liver steatohepatitis and fibrosis model.
Biomaterials 09, 2021 | Pubmed ID: 34304139
MMP2 Modulates Inflammatory Response during Axonal Regeneration in the Murine Visual System.
Cells 07, 2021 | Pubmed ID: 34359839
Tweaking Progranulin Expression: Therapeutic Avenues and Opportunities.
Frontiers in molecular neuroscience , 2021 | Pubmed ID: 34366786
Doxycycline inducible overexpression systems: how to induce your gene of interest without inducing misinterpretations.
Molecular biology of the cell 08, 2021 | Pubmed ID: 34383558
Fast and Efficient Generation of Isogenic Induced Pluripotent Stem Cell Lines Using Adenine Base Editing.
The CRISPR journal 08, 2021 | Pubmed ID: 34406036
Fetal hematopoietic stem cell homing is controlled by VEGF regulating the integrity and oxidative status of the stromal-vascular bone marrow niches.
Cell reports 08, 2021 | Pubmed ID: 34433017
Fluorescent tagging of endogenous Heme oxygenase-1 in human induced pluripotent stem cells for high content imaging of oxidative stress in various differentiated lineages.
Archives of toxicology 10, 2021 | Pubmed ID: 34480604
Organoid and microfluidics-based platforms for drug screening in COVID-19.
Drug discovery today 04, 2022 | Pubmed ID: 34954328
A Novel UPLC-MS Metabolomic Analysis-Based Strategy to Monitor the Course and Extent of iPSC Differentiation to Hepatocytes.
Journal of proteome research 03, 2022 | Pubmed ID: 34982937
HiPSC-Derived Hepatocyte-like Cells Can Be Used as a Model for Transcriptomics-Based Study of Chemical Toxicity.
Toxics Dec, 2021 | Pubmed ID: 35051043
Human iPSC model reveals a central role for NOX4 and oxidative stress in Duchenne cardiomyopathy.
Stem cell reports 02, 2022 | Pubmed ID: 35090586
Current Status and Challenges of Human Induced Pluripotent Stem Cell-Derived Liver Models in Drug Discovery.
Cells 01, 2022 | Pubmed ID: 35159250
An in vitro strategy using multiple human induced pluripotent stem cell-derived models to assess the toxicity of chemicals: A case study on paraquat.
Toxicology in vitro : an international journal published in association with BIBRA Jun, 2022 | Pubmed ID: 35182771
Metabolically Improved Stem Cell Derived Hepatocyte-Like Cells Support HBV Life Cycle and Are a Promising Tool for HBV Studies and Antiviral Drug Screenings.
Biomedicines Jan, 2022 | Pubmed ID: 35203482
Engineering neurovascular organoids with 3D printed microfluidic chips.
Lab on a chip 04, 2022 | Pubmed ID: 35333271
Senne Cuyx1,2,
Anabela S. Ramalho1,
Nikky Corthout3,4,
Steffen Fieuws5,
Eva Fürstová6,
Kaline Arnauts7,8,
Marc Ferrante7,9,
Catherine Verfaillie8,
Sebastian Munck3,4,
Mieke Boon1,2,
Marijke Proesmans1,2,
Lieven Dupont10,11,
Kris De Boeck1,2,
François Vermeulen1,2
1Department of Development and Regeneration, Woman and Child Unit, CF research lab, KU Leuven,
2Department of Pediatrics, Pediatric Pulmonology, University Hospitals Leuven,
3VIB Bio Imaging Core, VIB-KU Leuven Center for Brain & Disease Research,
4Department for Neuroscience, KU Leuven,
5Interuniversity Center for Biostatistics and Statistical Bioinformatics, University of Leuven and University of Hasselt,
6Department of Pediatrics, 2nd Faculty of Medicine, Charles University and Motol University Hospital,
7Department of Chronic Diseases and Metabolism (CHROMETA), Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven,
8Department of Development and Regeneration, Stem Cell Institute Leuven (SCIL), KU Leuven,
9Department of Gastroenterology and Hepatology, University Hospitals Leuven, KU Leuven,
10Department of Chronic Diseases, Metabolism and Ageing; Pneumology, KU Leuven,
11Department of Respiratory Diseases, University Hospitals Leuven
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