Department of Translational Neuroscience,
College of Human Medicine,
COVID-19 Early Detection Program
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Striatal Pleiotrophin Overexpression Provides Functional and Morphological Neuroprotection in the 6-Hydroxydopamine Model.
Molecular therapy : the journal of the American Society of Gene Therapy Oct, 2011 | Pubmed ID: 22008908
Subthalamic Nucleus Stimulation Increases Brain Derived Neurotrophic Factor in the Nigrostriatal System and Primary Motor Cortex.
Journal of Parkinson's disease May, 2011 | Pubmed ID: 22328911
Recombinant adenoassociated virus 2/5-mediated gene transfer is reduced in the aged rat midbrain.
Neurobiology of aging Feb, 2015 | Pubmed ID: 25457558
The longitudinal transcriptomic response of the substantia nigra to intrastriatal 6-hydroxydopamine reveals significant upregulation of regeneration-associated genes.
PloS one , 2015 | Pubmed ID: 25992874
High-Frequency Stimulation of the Rat Entopeduncular Nucleus Does Not Provide Functional or Morphological Neuroprotection from 6-Hydroxydopamine.
PloS one , 2015 | Pubmed ID: 26222442
Sonic Hedgehog Controls the Phenotypic Fate and Therapeutic Efficacy of Grafted Neural Precursor Cells in a Model of Nigrostriatal Neurodegeneration.
PloS one , 2015 | Pubmed ID: 26340267
Subthalamic Nucleus Deep Brain Stimulation Employs trkB Signaling for Neuroprotection and Functional Restoration.
The Journal of neuroscience : the official journal of the Society for Neuroscience 07, 2017 | Pubmed ID: 28607168
Subthalamic Nucleus Deep Brain Stimulation Does Not Modify the Functional Deficits or Axonopathy Induced by Nigrostriatal α-Synuclein Overexpression.
Scientific reports Nov, 2017 | Pubmed ID: 29180681
Bdnf variant is associated with milder motor symptom severity in early-stage Parkinson's disease.
Parkinsonism & related disorders 08, 2018 | Pubmed ID: 29759928
Parkinson's disease-linked knockin mice manifest tau neuropathology and dopaminergic neurodegeneration.
Proceedings of the National Academy of Sciences of the United States of America 03, 2019 | Pubmed ID: 30842285
Striatal Nurr1, but not FosB expression links a levodopa-induced dyskinesia phenotype to genotype in Fisher 344 vs. Lewis hemiparkinsonian rats.
Experimental neurology 08, 2020 | Pubmed ID: 32387398
Developmental exposure to the organochlorine pesticide dieldrin causes male-specific exacerbation of α-synuclein-preformed fibril-induced toxicity and motor deficits.
Neurobiology of disease 07, 2020 | Pubmed ID: 32422283
BDNF rs6265 Variant Alters Outcomes with Levodopa in Early-Stage Parkinson's Disease.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics Oct, 2020 | Pubmed ID: 33215284
Striatal afferent BDNF is disrupted by synucleinopathy and partially restored by STN DBS.
The Journal of neuroscience : the official journal of the Society for Neuroscience Jan, 2021 | Pubmed ID: 33472823
α-Synuclein antisense oligonucleotides as a disease-modifying therapy for Parkinson's disease.
JCI insight 03, 2021 | Pubmed ID: 33682798
BDNF rs6265 Genotype Influences Outcomes of Pharmacotherapy and Subthalamic Nucleus Deep Brain Stimulation in Early-Stage Parkinson's Disease.
Neuromodulation : journal of the International Neuromodulation Society Jul, 2021 | Pubmed ID: 34288271
Beta2-adrenoreceptor agonist clenbuterol produces transient decreases in alpha-synuclein mRNA but no long-term reduction in protein.
NPJ Parkinson's disease May, 2022 | Pubmed ID: 35610264
Joseph R. Patterson1,2,3,
Allyson Cole-Strauss1,2,3,
Nathan Kuhn1,2,
Carlene Mercier3,4,
Joseph Kochmanski1,2,
John A. Gerlach5,
Rhiannon M. LeVeque3,4,
Kerri A. Neugebauer3,4,6,
Kayla N. Conner3,4,
Jasper Gomez3,4,
Mark G. Hennes3,4,
Kaje’ne E. Thompson3,4,
Destinee L. Rytlewski3,4,
Chloe C. Bigwood3,4,
Amy Scharmen3,4,
Gabriel Simjanovski3,4,
Cassidy Riley3,4,
Jessica Donaldson3,4,
Dilann Yasin3,4,
Najwa Kouja3,5,
Zaria Contejean3,4,
Michaela Burnett3,4,
Shakhlo Aminova3,4,
Nat Ato Yawson3,4,7,
Simran B. Singh3,4,
Osama M. Alian3,4,
Carson D. Broeker3,4,8,
Erin K. Zaluzec3,4,7,
Morgan ONeill3,4,9,
Birgit Puschner10,
Aron Sousa2,
Laura Bix11,
Brian Jespersen2,
Claudia Holzman12,
Jade Mitchell13,
Ryan Julien13,
Yesim Askin14,
Danielle Barnes14,
Purna Durshanpalli14,
Doug Krum14,
Rett Weber14,
Morgan Patterson14,
Becky Anderson14,
Ryan Hunt14,
Benjamin O’Brien14,
Andrew Umstead1,2,
John S. Beck1,2,
Irving E. Vega1,2,
Caryl E. Sortwell1,2,
Jack W. Lipton1,2
1Department of Translational Neuroscience, Michigan State University,
2College of Human Medicine, Michigan State University,
3COVID-19 Early Detection Program, Michigan State University,
4Department of Microbiology and Molecular Genetics, Michigan State University,
5Biomedical Laboratory Diagnostics Program, Michigan State University,
6Department of Plant, Soil, and Microbial Sciences, Michigan State University,
7Department of Pharmacology and Toxicology, Michigan State University,
8Department of Biochemistry and Molecular Biology, Michigan State University,
9College of Osteopathic Medicine, Michigan State University,
10College of Veterinary Medicine, Michigan State University,
11School of Packaging, Michigan State University,
12Department of Epidemiology and Biostatistics, Michigan State University,
13Department of Biosystems Engineering, Michigan State University,
14Enterprise Services, Michigan State University
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