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Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinoma by K-Ras oncogenes in adult mice.
Cancer cell Mar, 2007 | Pubmed ID: 17349585
Pancreatitis-induced inflammation contributes to pancreatic cancer by inhibiting oncogene-induced senescence.
Cancer cell Jun, 2011 | Pubmed ID: 21665147
Genetically engineered mouse models of pancreatic adenocarcinoma.
Molecular oncology Apr, 2013 | Pubmed ID: 23506980
K-RasV14I recapitulates Noonan syndrome in mice.
Proceedings of the National Academy of Sciences of the United States of America Nov, 2014 | Pubmed ID: 25359213
Modeling RASopathies with Genetically Modified Mouse Models.
Methods in molecular biology (Clifton, N.J.) , 2017 | Pubmed ID: 27924582
Saa3 is a key mediator of the protumorigenic properties of cancer-associated fibroblasts in pancreatic tumors.
Proceedings of the National Academy of Sciences of the United States of America Feb, 2018 | Pubmed ID: 29351990
Complete Regression of Advanced Pancreatic Ductal Adenocarcinomas upon Combined Inhibition of EGFR and C-RAF.
Cancer cell Apr, 2019 | Pubmed ID: 30975481
the Biomedical Research Network in Cancer (CIBERONC)
Centro Nacional de Investigaciones Oncológicas (CNIO)
Jesús Frutos Díaz-Alejo*,1,2,3,4,
Simon April-Monn*,5,
Marina Cihova6,
Verona Buocikova6,
Jorge Villalón López1,3,
Maria Urbanova6,
Carmen G. Lechuga7,
Miroslav Tomas6,8,
Peter Dubovan6,8,
Bárbara Luna Sánchez3,
Sonia Camaño Páez3,
Alfonso Sanjuanbenito2,9,
Eduardo Lobo9,
Estefanía Romio de la Heras10,
Carmen Guerra2,7,
Carolina de la Pinta11,
Emma Barreto Melian1,2,
Mercedes Rodríguez Garrote1,2,
Alfredo Carrato1,2,4,
Laura Ruiz-Cañas3,12,13,
Bruno Sainz, Jr.2,3,12,13,
Ana Torres3,
Bozena Smolkova6,
Julie Earl1,2,3
1Molecular Epidemiology and Predictive Tumor Markers Group, Area 3, Ramón y Cajal Health Research Institute (IRYCIS),
2, The Biomedical Research Network in Cancer (CIBERONC),
3Biobank and Biomodels Platform (PT20/0045), ISCIII research and development platforms in biomedicine and health sciences, BioBank Hospital Ramón y Cajal-IRYCIS, Spanish National Biobanks Network (ISCIII Biobank Register No. B.0000678), Ramón y Cajal Health Research Institute (IRYCIS),
4Faculty of Medicine, University of Alcalá de Henares,
5Institute of Tissue Medicine and Pathology, University of Bern,
6Department of Molecular Oncology, Cancer Research Institute, Biomedical Research Center of the Slovak Academy of Sciences,
7Experimental Oncology, Molecular Oncology Program, Centro Nacional de Investigaciones Oncológicas (CNIO),
8Department of Surgical Oncology, National Cancer Institute, Slovak Medical University,
9Pancreatic and Biliopancreatic Surgery Unit, Hospital Universitario Ramón y Cajal,
10Department of Pathology, Hospital Universitario Ramón y Cajal,
11Department of Radiation Oncology, Hospital Universitario Ramón y Cajal,
12Department of Cancer, Instituto de Investigaciones Biomédicas “Alberto Sols” (IIBM),
13Cancer Stem Cell and Fibroinflammatory Group, Chronic Diseases and Cancer, Area 3, IRYCIS
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