Yingfu Li

Sequence diversity, metal specificity, and catalytic proficiency of metal-dependent phosphorylating DNA enzymes.

Tripartite molecular beacons.

Making AppDNA using T4 DNA ligase.

An efficient RNA-cleaving DNA enzyme that synchronizes catalysis with fluorescence signaling.

Affinity analysis of a protein-aptamer complex using nonequilibrium capillary electrophoresis of equilibrium mixtures.

Structure-switching signaling aptamers.

Assemblage of signaling DNA enzymes with intriguing metal-ion specificities and pH dependences.

Ligating DNA with DNA.

Structure-switching signaling aptamers: transducing molecular recognition into fluorescence signaling.

Dinucleotide junction cleavage versatility of 8-17 deoxyribozyme.

Tracing sequence diversity change of RNA-cleaving deoxyribozymes under increasing selection pressure during in vitro selection.

Signaling aptamers for monitoring enzymatic activity and for inhibitor screening.

Synthesis and characterization of topologically linked single-stranded DNA rings.

In vitro selection of structure-switching signaling aptamers.

Benzimidazole derivatives as novel nonpeptide luteinizing hormone-releasing hormone (LHRH) antagonists. Part 1: Benzimidazole-5-sulfonamides.

Benzimidazole derivatives as novel nonpeptide luteinizing hormone-releasing hormone (LHRH) antagonists. Part 2: Benzimidazole-5-sulfonamides.

Tau protein binds single-stranded DNA sequence specifically--the proof obtained in vitro with non-equilibrium capillary electrophoresis of equilibrium mixtures.

Secondary-structure characterization of two proficient kinase deoxyribozymes.

Benzimidazoles as non-peptide luteinizing hormone-releasing hormone (LHRH) antagonists. Part 3: Discovery of 1-(1H-benzimidazol-5-yl)-3-tert-butylurea derivatives.

Diverse evolutionary trajectories characterize a community of RNA-cleaving deoxyribozymes: a case study into the population dynamics of in vitro selection.

Entrapment of fluorescent signaling DNA aptamers in sol-gel-derived silica.

A DNA-protein nanoengine for "on-demand" release and precise delivery of molecules.

Characterizing the secondary structure and identifying functionally essential nucleotides of pH6DZ1, a fluorescence-signaling and RNA-cleaving deoxyribozyme.

Aptamers with fluorescence-signaling properties.

Benzimidazole-5-sulfonamides as novel nonpeptide luteinizing hormone releasing hormone (LHRH) antagonists: minimization of mechanism-based CYP3A4 inhibition.

Characterization of a catalytically efficient acidic RNA-cleaving deoxyribozyme.

Quenching of fluorophore-labeled DNA oligonucleotides by divalent metal ions: implications for selection, design, and applications of signaling aptamers and signaling deoxyribozymes.

Revitalization of six abandoned catalytic DNA species reveals a common three-way junction framework and diverse catalytic cores.

DNA polymerization on gold nanoparticles through rolling circle amplification: towards novel scaffolds for three-dimensional periodic nanoassemblies.

Solid-phase enzyme activity assay utilizing an entrapped fluorescence-signaling DNA aptamer.

Nucleic acid aptamers and enzymes as sensors.

Characterization of long RNA-cleaving deoxyribozymes with short catalytic cores: the effect of excess sequence elements on the outcome of in vitro selection.

Phosphoester-transfer mechanism of an RNA-cleaving acidic deoxyribozyme revealed by radioactivity tracking and enzymatic digestion.

Small-molecule screening made simple for a difficult target with a signaling nucleic acid aptamer that reports on deaminase activity.

Catalysis and rational engineering of trans-acting pH6DZ1, an RNA-cleaving and fluorescence-signaling deoxyribozyme with a four-way junction structure.

Long-period grating refractive index sensor with a modified cladding structure for large operational range and high sensitivity.

Wrapping single-walled carbon nanotubes with long single-stranded DNA molecules produced by rolling circle amplification.

Evolution of high-branching deoxyribozymes from a catalytic DNA with a three-way junction.

Characterization of a fluorescence-signaling and RNA-cleaving deoxyribozyme.

Efficient signaling platforms built from a small catalytic DNA and doubly labeled fluorogenic substrates.

Adsorption and covalent coupling of ATP-binding DNA aptamers onto cellulose.

Multiple occurrences of an efficient self-phosphorylating deoxyribozyme motif.

A synthetic luxCDABE gene cluster optimized for expression in high-GC bacteria.

Entrapment of fluorescence signaling DNA enzymes in sol-gel-derived materials for metal ion sensing.

Simple and rapid colorimetric biosensors based on DNA aptamer and noncrosslinking gold nanoparticle aggregation.

Aptamers and small molecules play tug of war.

Simple and rapid colorimetric enzyme sensing assays using non-crosslinking gold nanoparticle aggregation.

Isolation of DNA aptamers for CDP-ribitol synthase, and characterization of their inhibitory and structural properties.

Enzymatic manipulations of DNA oligonucleotides on microgel: towards development of DNA-microgel bioassays.

Understanding DNA-based catalysis one molecule at a time.

Enzymatic incorporation of 2-amino-6-vinylpurine derivative.

Simple fluorescent sensors engineered with catalytic DNA 'MgZ' based on a non-classic allosteric design.

A deoxyribozyme with a novel guanine quartet-helix pseudoknot structure.

Sequence-function relationships provide new insight into the cleavage site selectivity of the 8-17 RNA-cleaving deoxyribozyme.

Microgel-based inks for paper-supported biosensing applications.

DNA aptamer folding on gold nanoparticles: from colloid chemistry to biosensors.

Chemical biology meets systems biology. Introduction.

Enzymatic cleavage of nucleic acids on gold nanoparticles: a generic platform for facile colorimetric biosensors.

A FACS-based approach to engineering artificial riboswitches.

In vitro selection of small RNA-cleaving deoxyribozymes that cleave pyrimidine-pyrimidine junctions.

Rolling circle amplification: applications in nanotechnology and biodetection with functional nucleic acids.

Investigation of DNA as a catalyst for Henry reaction in water.

Design of gold nanoparticle-based colorimetric biosensing assays.

Paper-based bioassays using gold nanoparticle colorimetric probes.

Periodic assembly of nanospecies on repetitive DNA sequences generated on gold nanoparticles by rolling circle amplification.

DNAzyme-mediated catalysis with only guanosine and cytidine nucleotides.

Identification of a toxic peptide through bidirectional expression of small RNAs.

In vitro selection of protein-binding DNA aptamers as ligands for biosensing applications.

Incorporation of an inducible nucleotide analog into DNA by DNA polymerases.

Biologically inspired synthetic enzymes made from DNA.

A genotype-to-phenotype map of in vitro selected RNA-cleaving DNAzymes: implications for accessing the target phenotype.

Colorimetric sensing by using allosteric-DNAzyme-coupled rolling circle amplification and a peptide nucleic acid-organic dye probe.

Kinetics of signaling-DNA-aptamer-ATP binding.

Characterization of an RNA-cleaving deoxyribozyme with optimal activity at pH 5.

Detection of DNA using bioactive paper strips.

A versatile endoribonuclease mimic made of DNA: characteristics and applications of the 8-17 RNA-cleaving DNAzyme.

A complex RNA-cleaving DNAzyme that can efficiently cleave a pyrimidine-pyrimidine junction.

Using a riboswitch sensor to examine coenzyme B(12) metabolism and transport in E. coli.

Influence of cleavage site on global folding of an RNA-cleaving DNAzyme.

Probing the function of nucleotides in the catalytic cores of the 8-17 and 10-23 DNAzymes by abasic nucleotide and C3 spacer substitutions.

A general approach to the construction of structure-switching reporters from RNA aptamers.

The structural diversity of deoxyribozymes.

Decoding toxicity: deducing the sequence requirements of IbsC, a type I toxin in Escherichia coli.

Surface immobilization of structure-switching DNA aptamers on macroporous sol-gel-derived films for solid-phase biosensing applications.

Modulation of DNA-modified gold-nanoparticle stability in salt with concatemeric single-stranded DNAs for colorimetric bioassay development.

Fluorogenic DNAzyme probes as bacterial indicators.

Characterization of non-8-17 sequences uncovers structurally diverse RNA-cleaving deoxyribozymes.

Enhancing sensitivity and selectivity of long-period grating sensors using structure-switching aptamers bound to gold-doped macroporous silica coatings.

Advancements in using reporter DNAzymes for identifying pathogenic bacteria at speed and with convenience.

Developing fluorogenic RNA-cleaving DNAzymes for biosensing applications.

Multiplexed paper test strip for quantitative bacterial detection.

Stabilizing structure-switching signaling RNA aptamers by entrapment in sol-gel derived materials for solid-phase assays.

Lighting Up RNA-Cleaving DNAzymes for Biosensing.

Artificially created nucleic acids and peptides/proteins in chemical biology.

A highly efficient molecular cloning platform that utilises a small bacterial toxin gene.

Quality control certification of RNA aptamer-based detection.

Turning a kinase deoxyribozyme into a sensor.

A novel phosphorescence sensor for Co(2+) ion based on Mn-doped ZnS quantum dots.

Therapeutic peptides: new arsenal against drug resistant pathogens.

Assessing the amount of quadruplex structures present within G₂-tract synthetic random-sequence DNA libraries.

Exploration of structure-switching in the design of aptamer biosensors.

Phosphorescence detection of L-ascorbic acid with surface-attached N-acetyl-L-cysteine and L-cysteine Mn doped ZnS quantum dots.

Lysozyme-stabilized gold nanoclusters as a novel fluorescence probe for cyanide recognition.

Evolving wonder-RNAs in a test tube.

Exploring intermolecular interactions of a substrate binding protein using a riboswitch-based sensor.

Construction and application of riboswitch-based sensors that detect metabolites within bacterial cells.

Turning tryptophanase into odor-generating biosensors.

Artificial riboswitch selection: A FACS-based approach.

Arrest of rolling circle amplification by protein-binding DNA aptamers.

Pullulan encapsulation of labile biomolecules to give stable bioassay tablets.

A graphene-based biosensing platform based on the release of DNA probes and rolling circle amplification.

Engineering interlocking DNA rings with weak physical interactions.

A sensitive DNA enzyme-based fluorescent assay for bacterial detection.

A general strategy to create RNA aptamer sensors using "regulated" graphene oxide adsorption.

An inkjet-printed bioactive paper sensor that reports ATP through odour generation.

Translating bacterial detection by DNAzymes into a litmus test.

A dual reporter system for detecting RNA interactions in bacterial cells.

Highly specific recognition of breast tumors by an RNA-cleaving fluorogenic DNAzyme probe.

Examination of bacterial inhibition using a catalytic DNA.

Fluorescence activation imaging of cytochrome c released from mitochondria using aptameric nanosensor.

Patterned paper sensors printed with long-chain DNA aptamers.

Optimal DNA templates for rolling circle amplification revealed by in vitro selection.

An Efficient Catalytic DNA that Cleaves L-RNA.

The association of adiponectin gene promoter variations with non-small cell lung cancer in a Han Chinese population.

Evolution of an Enzyme from a Noncatalytic Nucleic Acid Sequence.

Biosensing by Tandem Reactions of Structure Switching, Nucleolytic Digestion, and DNA Amplification of a DNA Assembly.

Printed paper sensors for serum lactate dehydrogenase using pullulan-based inks to immobilize reagents.

Optimized mixture of As, Cd and Pb induce mitochondria-mediated apoptosis in C6-glioma via astroglial activation, inflammation and P38-MAPK.

Sequence Mutation and Structural Alteration Transform a Noncatalytic DNA Sequence into an Efficient RNA-Cleaving DNAzyme.

A Quarter Century of In Vitro Selection.

A Catalytic DNA Activated by a Specific Strain of Bacterial Pathogen.

Target-Induced and Equipment-Free DNA Amplification with a Simple Paper Device.

Frozen vs Fresh Fecal Microbiota Transplantation and Clinical Resolution of Diarrhea in Patients With Recurrent Clostridium difficile Infection: A Randomized Clinical Trial.

Topological DNA Assemblies Containing Identical or Fraternal Twins.

In vitro selection of RNA-cleaving DNAzymes for bacterial detection.

Programming a topologically constrained DNA nanostructure into a sensor.