Department of Pharmaceutical Sciences,
College of Pharmacy,
Department of Pharmaceutical Sciences, College of Pharmacy
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The effect of CYP3A5 and MDR1 polymorphic expression on cyclosporine oral disposition in renal transplant patients.
Journal of clinical pharmacology Jun, 2003 | Pubmed ID: 12817518
Real-time PCR-based genotyping assay for CXCR2 polymorphisms.
Clinica chimica acta; international journal of clinical chemistry Mar, 2004 | Pubmed ID: 14967163
Pharmacokinetic aspects of biotechnology products.
Journal of pharmaceutical sciences Sep, 2004 | Pubmed ID: 15295780
SYBR Green-based real-time PCR allelic discrimination assay for beta2-adrenergic receptor polymorphisms.
Analytical biochemistry Sep, 2005 | Pubmed ID: 16026755
The clinical pharmacokinetics of phosphodiesterase-5 inhibitors for erectile dysfunction.
Journal of clinical pharmacology Sep, 2005 | Pubmed ID: 16100293
Population pharmacokinetic studies in pediatrics: issues in design and analysis.
The AAPS journal Oct, 2005 | Pubmed ID: 16353925
G2677T and C3435T genotype and haplotype are associated with hepatic ABCB1 (MDR1) expression.
Journal of clinical pharmacology Mar, 2006 | Pubmed ID: 16490813
LC/MS/MS in drug development: targeting the brain.
BioTechniques Jun, 2005 | Pubmed ID: 16528912
Discovery of novel isoxazolines as anti-tuberculosis agents.
Bioorganic & medicinal chemistry letters Dec, 2007 | Pubmed ID: 17937983
Population pharmacokinetics of cetuximab in patients with squamous cell carcinoma of the head and neck.
Journal of clinical pharmacology Mar, 2008 | Pubmed ID: 18218786
Biopharmaceutics, pharmacokinetics and pharmacodynamics of antituberculosis drugs.
Current medicinal chemistry , 2008 | Pubmed ID: 18393850
Pharmacokinetically-guided lead optimization of nitrofuranylamide anti-tuberculosis agents.
The AAPS journal , 2008 | Pubmed ID: 18446516
A microbiological assessment of novel nitrofuranylamides as anti-tuberculosis agents.
The Journal of antimicrobial chemotherapy Nov, 2008 | Pubmed ID: 18693235
A tandem mass spectrometry assay for the simultaneous determination of acetaminophen, caffeine, phenytoin, ranitidine, and theophylline in small volume pediatric plasma specimens.
Clinica chimica acta; international journal of clinical chemistry Dec, 2008 | Pubmed ID: 18796299
Concepts and challenges in quantitative pharmacology and model-based drug development.
The AAPS journal Dec, 2008 | Pubmed ID: 19003542
A simple in vitro PK/PD model system to determine time-kill curves of drugs against Mycobacteria.
Tuberculosis (Edinburgh, Scotland) Sep, 2009 | Pubmed ID: 19748318
Predictors of mortality in elderly subjects with obstructive airway disease: the PILE score.
Annals of epidemiology Mar, 2010 | Pubmed ID: 20159492
Genetic ancestry in lung-function predictions.
The New England journal of medicine Jul, 2010 | Pubmed ID: 20647190
Population pharmacokinetics of therapeutic monoclonal antibodies.
Clinical pharmacokinetics Oct, 2010 | Pubmed ID: 20818831
Discovery of novel 2-aryl-4-benzoyl-imidazoles targeting the colchicines binding site in tubulin as potential anticancer agents.
Journal of medicinal chemistry Oct, 2010 | Pubmed ID: 20919720
Pharmacokinetics of a combination of Δ9-tetrahydro-cannabinol and celecoxib in a porcine model of hemorrhagic shock.
Biopharmaceutics & drug disposition Mar, 2011 | Pubmed ID: 21341278
In vitro pharmacokinetic/pharmacodynamic models in anti-infective drug development: focus on TB.
Future medicinal chemistry Aug, 2010 | Pubmed ID: 21359155
Is age-related decline in lean mass and physical function accelerated by obstructive lung disease or smoking?
Thorax Nov, 2011 | Pubmed ID: 21724748
Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function.
Nature genetics Sep, 2011 | Pubmed ID: 21946350
Comparative performance of cell life span and cell transit models for describing erythropoietic drug effects.
The AAPS journal Dec, 2011 | Pubmed ID: 22005901
Population pharmacokinetic/pharmacodynamic analyses as the basis for dosing of therapeutic monoclonal antibodies.
Clinical pharmacokinetics Dec, 2011 | Pubmed ID: 22087868
Characterizing the impact of renal impairment on the clinical pharmacology of biologics.
Journal of clinical pharmacology Jan, 2012 | Pubmed ID: 22232754
Immunogenicity to therapeutic proteins: impact on PK/PD and efficacy.
The AAPS journal Jun, 2012 | Pubmed ID: 22407289
Evaluation of vancomycin dosing regimens in preterm and term neonates using Monte Carlo simulations.
Pharmacotherapy May, 2012 | Pubmed ID: 22488303
Genetic ancestry-smoking interactions and lung function in African Americans: a cohort study.
PloS one , 2012 | Pubmed ID: 22737244
The influence of abdominal visceral fat on inflammatory pathways and mortality risk in obstructive lung disease.
The American journal of clinical nutrition Sep, 2012 | Pubmed ID: 22811442
The current role of model-based drug development.
Expert opinion on drug discovery Apr, 2010 | Pubmed ID: 22823084
Genome Wide Association Studies Identify CHRNA5/3 and HTR4 in the Development of Airflow Obstruction.
American journal of respiratory and critical care medicine Jul, 2012 | Pubmed ID: 22837378
Developing a gene expression model for predicting ventilator-associated pneumonia in trauma patients: a pilot study.
PloS one , 2012 | Pubmed ID: 22916119
Antitubercular nitrofuran isoxazolines with improved pharmacokinetic properties.
Bioorganic & medicinal chemistry Oct, 2012 | Pubmed ID: 22995771
Simple and sensitive assay for quantification of oseltamivir and its active metabolite oseltamivir carboxylate in human plasma using high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry: improved applicability to pharmacokinetic study.
Journal of pharmaceutical and biomedical analysis Jan, 2013 | Pubmed ID: 23000242
Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function.
PLoS genetics , 2012 | Pubmed ID: 23284291
Strategic biomarkers for drug development in treating rare diseases and diseases in neonates and infants.
The AAPS journal Apr, 2013 | Pubmed ID: 23334978
Applications of pharmacometrics in the clinical development and pharmacotherapy of anti-infectives.
Expert review of clinical pharmacology Mar, 2013 | Pubmed ID: 23473593
Pharmacokinetics and pharmacokinetic-pharmacodynamic correlations of therapeutic peptides.
Clinical pharmacokinetics Oct, 2013 | Pubmed ID: 23719681
Pharmacokinetic profile of spectinomycin in rats.
Die Pharmazie Aug, 2013 | Pubmed ID: 24020122
Spectinamides: a new class of semisynthetic antituberculosis agents that overcome native drug efflux.
Nature medicine Feb, 2014 | Pubmed ID: 24464186
Novel endogenous glycan therapy for retinal diseases: safety, in vitro stability, ocular pharmacokinetic modeling, and biodistribution.
The AAPS journal Mar, 2014 | Pubmed ID: 24470212
Pentacyclic nitrofurans with in vivo efficacy and activity against nonreplicating Mycobacterium tuberculosis.
PloS one , 2014 | Pubmed ID: 24505329
Large-scale genome-wide association studies and meta-analyses of longitudinal change in adult lung function.
PloS one , 2014 | Pubmed ID: 24983941
Protein engineering for improved pharmacologic characteristics of established monoclonal antibody-based therapeutics.
Clinical pharmacokinetics Oct, 2014 | Pubmed ID: 25212704
Effects of alcohol on human carboxylesterase drug metabolism.
Clinical pharmacokinetics Jun, 2015 | Pubmed ID: 25511794
Ethanol lock therapy: a pilot infusion study in infants.
The Annals of pharmacotherapy Apr, 2015 | Pubmed ID: 25632063
Clinical pharmacology of bispecific antibody constructs.
Journal of clinical pharmacology Mar, 2015 | Pubmed ID: 25707960
Aminomethyl spectinomycins as therapeutics for drug-resistant respiratory tract and sexually transmitted bacterial infections.
Science translational medicine May, 2015 | Pubmed ID: 25995221
Human Ontogeny of Drug Transporters: Review and Recommendations of the Pediatric Transporter Working Group.
Clinical pharmacology and therapeutics Sep, 2015 | Pubmed ID: 26088472
Preclinical evaluation of SMM-189, a cannabinoid receptor 2-specific inverse agonist.
Pharmacology research & perspectives Aug, 2015 | Pubmed ID: 26196013
Pattern Recognition in Pharmacokinetic Data Analysis.
The AAPS journal Jan, 2016 | Pubmed ID: 26338231
In vitro and in vivo Evaluation of Synergism between Anti-Tubercular Spectinamides and Non-Classical Tuberculosis Antibiotics.
Scientific reports Sep, 2015 | Pubmed ID: 26365087
Effect of Ethanol on the Metabolic Characteristics of HIV-1 Integrase Inhibitor Elvitegravir and Elvitegravir/Cobicistat with CYP3A: An Analysis Using a Newly Developed LC-MS/MS Method.
PloS one , 2016 | Pubmed ID: 26872388
Tissue Penetration of a Novel Spectinamide Antibiotic for the Treatment of Tuberculosis.
The AAPS journal May, 2016 | Pubmed ID: 26984832
Phase II Metabolic Pathways of Spectinamide Antitubercular Agents: A Comparative Study of the Reactivity of 4-Substituted Pyridines to Glutathione Conjugation.
MedChemComm Jan, 2016 | Pubmed ID: 27042286
Expression Patterns of Organic Anion Transporting Polypeptides 1B1 and 1B3 Protein in Human Pediatric Liver.
Drug metabolism and disposition: the biological fate of chemicals Jul, 2016 | Pubmed ID: 27098745
Drug Development of Therapeutic Monoclonal Antibodies.
BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy Aug, 2016 | Pubmed ID: 27342605
Translational PK/PD of anti-infective therapeutics.
Drug discovery today. Technologies , 2016 | Pubmed ID: 27978987
Immune Suppression During Preclinical Drug Development Mitigates Immunogenicity-Mediated Impact on Therapeutic Exposure.
The AAPS journal Mar, 2017 | Pubmed ID: 28070711
Structure-Activity Relationships of Spectinamide Antituberculosis Agents: A Dissection of Ribosomal Inhibition and Native Efflux Avoidance Contributions.
ACS infectious diseases Jan, 2017 | Pubmed ID: 28081607
Alterations in cellular pharmacokinetics and pharmacodynamics of elvitegravir in response to ethanol exposure in HIV-1 infected monocytic (U1) cells.
PloS one , 2017 | Pubmed ID: 28231276
A New Combination of a Pleuromutilin Derivative and Doxycycline for Treatment of Multidrug-Resistant Acinetobacter baumannii.
Journal of medicinal chemistry Apr, 2017 | Pubmed ID: 28291943
Regulatory and Ethical Issues in Pediatric Clinical Research: Recommendations From a Panel Discussion.
Journal of clinical pharmacology Aug, 2017 | Pubmed ID: 28513861
Core Entrustable Professional Activities in Clinical Pharmacology for Entering Residency: Biologics.
Journal of clinical pharmacology Aug, 2017 | Pubmed ID: 28614591
Influence of Ethanol on Darunavir Hepatic Clearance and Intracellular PK/PD in HIV-Infected Monocytes, and CYP3A4-Darunavir Interactions Using Inhibition and in Silico Binding Studies.
Pharmaceutical research Sep, 2017 | Pubmed ID: 28616684
Pharmacokinetics of Monoclonal Antibodies.
CPT: pharmacometrics & systems pharmacology Sep, 2017 | Pubmed ID: 28653357
Comparison of caffeine disposition following administration by oral solution (energy drink) and inspired powder (AeroShot) in human subjects.
British journal of clinical pharmacology Dec, 2017 | Pubmed ID: 28758694
Sustained plasma hepcidin suppression and iron elevation by Anticalin-derived hepcidin antagonist in cynomolgus monkey.
British journal of pharmacology Apr, 2018 | Pubmed ID: 29329501
Primary Lung Dendritic Cell Cultures to Assess Efficacy of Spectinamide-1599 Against Intracellular .
Frontiers in microbiology , 2018 | Pubmed ID: 30186246
Tannic acid-inspired paclitaxel nanoparticles for enhanced anticancer effects in breast cancer cells.
Journal of colloid and interface science Feb, 2019 | Pubmed ID: 30292104
Pharmacometric Applications and Challenges in the Development of Therapeutic Antibodies in Immuno-Oncology.
Current pharmacology reports Aug, 2018 | Pubmed ID: 30319936
The Journey to AAPS 2020: a Reflection from Strategic Planning to PharmSci 360.
AAPS PharmSciTech Nov, 2018 | Pubmed ID: 30390237
The Journey to AAPS 2020: a Reflection from Strategic Planning to PharmSci 360.
The AAPS journal Nov, 2018 | Pubmed ID: 30392015
Dynamic time-kill curve characterization of spectinamide antibiotics 1445 and 1599 for the treatment of tuberculosis.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences Jan, 2019 | Pubmed ID: 30419293
Comparative pharmacokinetics of spectinamide 1599 after subcutaneous and intrapulmonary aerosol administration in mice.
Tuberculosis (Edinburgh, Scotland) Jan, 2019 | Pubmed ID: 30711150
Core Entrustable Professional Activities in Clinical Pharmacology for Entering Residency: Common Problem Drugs and How to Prescribe Them.
Journal of clinical pharmacology Jul, 2019 | Pubmed ID: 30768795
Population pharmacokinetic meta-analysis of individual data to design the first randomized efficacy trial of vancomycin in neonates and young infants.
The Journal of antimicrobial chemotherapy Aug, 2019 | Pubmed ID: 31049551
Development and Characterization of a Dry Powder Formulation for Anti-Tuberculosis Drug Spectinamide 1599.
Pharmaceutical research Jul, 2019 | Pubmed ID: 31321552
Sterilization of Mycobacterium tuberculosis infected samples using methanol preserves anti-tuberculosis drugs for subsequent pharmacological testing studies.
Tuberculosis (Edinburgh, Scotland) Jul, 2019 | Pubmed ID: 31378268
Cross-Linked Polyphenol-Based Drug Nano-Self-Assemblies Engineered to Blockade Prostate Cancer Senescence.
ACS applied materials & interfaces Oct, 2019 | Pubmed ID: 31553876
Immunogenicity in Clinical Practice and Drug Development: When is it Significant?
Clinical and translational science Mar, 2020 | Pubmed ID: 31762152
Effective Removal of Dabigatran by Idarucizumab or Hemodialysis: A Physiologically Based Pharmacokinetic Modeling Analysis.
Clinical pharmacokinetics Jun, 2020 | Pubmed ID: 32020532
Pharmacokinetics and Clinical Pharmacology of Monoclonal Antibodies in Pediatric Patients.
Paediatric drugs Apr, 2020 | Pubmed ID: 32052309
Physiologically-Based Pharmacokinetic (PBPK) Modeling Providing Insights into Fentanyl Pharmacokinetics in Adults and Pediatric Patients.
Pharmaceutics Sep, 2020 | Pubmed ID: 32977559
Pharmacological principles guiding prolonged glucocorticoid treatment in ARDS.
Intensive care medicine Dec, 2020 | Pubmed ID: 33150472
Discovery of -(3,4-Dimethylphenyl)-4-(4-isobutyrylphenyl)-2,3,3a,4,5,9b-hexahydrofuro[3,2-]quinoline-8-sulfonamide as a Potent Dual MDM2/XIAP Inhibitor.
Journal of medicinal chemistry Feb, 2021 | Pubmed ID: 33556244
Use of Real-World Data and Pharmacometric Modeling in Support of Lacosamide Dosing in Pediatric Patients Under 4 Years of Age.
Journal of clinical pharmacology Jul, 2021 | Pubmed ID: 33599301
Drug Clearance in Neonates: A Combination of Population Pharmacokinetic Modelling and Machine Learning Approaches to Improve Individual Prediction.
Clinical pharmacokinetics Nov, 2021 | Pubmed ID: 34041714
Pediatric Dose Selection for Therapeutic Proteins.
Journal of clinical pharmacology Jun, 2021 | Pubmed ID: 34185910
Time to 'Mind the Gap' in novel small molecule drug discovery for direct-acting antivirals for SARS-CoV-2.
Current opinion in virology Oct, 2021 | Pubmed ID: 34256351
X-ray Crystallography-Guided Design, Antitumor Efficacy, and QSAR Analysis of Metabolically Stable Cyclopenta-Pyrimidinyl Dihydroquinoxalinone as a Potent Tubulin Polymerization Inhibitor.
Journal of medicinal chemistry Sep, 2021 | Pubmed ID: 34406768
Preclinical Evaluation of Inhalational Spectinamide-1599 Therapy against Tuberculosis.
ACS infectious diseases Oct, 2021 | Pubmed ID: 34546724
Drug Repurposing to Identify Nilotinib as a Potential SARS-CoV-2 Main Protease Inhibitor: Insights from a Computational and Study.
Journal of chemical information and modeling Nov, 2021 | Pubmed ID: 34666487
Knowledge Gaps in the Pharmacokinetics of Therapeutic Proteins in Pediatric Patients.
Frontiers in pharmacology , 2022 | Pubmed ID: 35222051
Colchicine-Binding Site Agent CH-2-77 as a Potent Tubulin Inhibitor Suppressing Triple-Negative Breast Cancer.
Molecular cancer therapeutics Jul, 2022 | Pubmed ID: 35499388
Alcohol inhibits the metabolism of dimethyl fumarate to the active metabolite responsible for decreasing relapse frequency in the treatment of multiple sclerosis.
PloS one , 2022 | Pubmed ID: 36441753
SB226, an inhibitor of tubulin polymerization, inhibits paclitaxel-resistant melanoma growth and spontaneous metastasis.
Cancer letters Feb, 2023 | Pubmed ID: 36596380
Spray dried tigecycline dry powder aerosols for the treatment of Nontuberculous mycobacterial pulmonary infections.
Tuberculosis (Edinburgh, Scotland) Mar, 2023 | Pubmed ID: 36716525
Barriers to global pharmacometrics: educational challenges and opportunities across the globe.
CPT: pharmacometrics & systems pharmacology Jun, 2023 | Pubmed ID: 36960632
TNX-1500, a crystallizable fragment-modified anti-CD154 antibody, prolongs nonhuman primate renal allograft survival.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons Aug, 2023 | Pubmed ID: 37019335
TNX-1500, a crystallizable fragment-modified anti-CD154 antibody, prolongs nonhuman primate cardiac allograft survival.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons Aug, 2023 | Pubmed ID: 37030662
Efficacy of a brain-penetrant antiviral in lethal Venezuelan and eastern equine encephalitis mouse models.
Science translational medicine Apr, 2023 | Pubmed ID: 37043558
Novel, Brain-Permeable, Cross-Species Benzothiazole Inhibitors of Microsomal Prostaglandin E Synthase-1 (mPGES-1) Dampen Neuroinflammation and .
ACS pharmacology & translational science Apr, 2023 | Pubmed ID: 37082746
Design, Synthesis, and Biological Evaluation of Pyrimidine Dihydroquinoxalinone Derivatives as Tubulin Colchicine Site-Binding Agents That Displayed Potent Anticancer Activity Both In Vitro and In Vivo.
ACS pharmacology & translational science Apr, 2023 | Pubmed ID: 37082747
Characterization of spectinamide 1599 efficacy against different mycobacterial phenotypes.
Tuberculosis (Edinburgh, Scotland) May, 2023 | Pubmed ID: 37120915
Use of Machine Learning for Dosage Individualization of Vancomycin in Neonates.
Clinical pharmacokinetics Aug, 2023 | Pubmed ID: 37300630
Clinical and Translational Pharmacology Considerations for Anti-infectives Approved Under the FDA Animal Rule.
Clinical pharmacokinetics Jul, 2023 | Pubmed ID: 37326917
Development of a Minimalistic Physiologically Based Pharmacokinetic (mPBPK) Model for the Preclinical Development of Spectinamide Antibiotics.
Pharmaceutics Jun, 2023 | Pubmed ID: 37376207
The inducible prostaglandin E synthase (mPGES-1) in neuroinflammatory disorders.
Experimental biology and medicine (Maywood, N.J.) May, 2023 | Pubmed ID: 37515545
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