Department of Pathology,
Division of Infectious Diseases and HIV Medicine,
Department of Medicine,
Division of Infectious Diseases and HIV Medicine, Department of Medicine
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CD40 induces macrophage anti-Toxoplasma gondii activity by triggering autophagy-dependent fusion of pathogen-containing vacuoles and lysosomes.
The Journal of clinical investigation Sep, 2006 | Pubmed ID: 16955139
CD40-TRAF6 and autophagy-dependent anti-microbial activity in macrophages.
Autophagy , 2007 | Pubmed ID: 17224624
Role of CD40-dependent down-regulation of CD154 in impaired induction of CD154 in CD4(+) T cells from HIV-1-infected patients.
Journal of immunology (Baltimore, Md. : 1950) Feb, 2007 | Pubmed ID: 17237414
Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes.
Autophagy Feb, 2008 | Pubmed ID: 18188003
CD40 mediates retinal inflammation and neurovascular degeneration.
Journal of immunology (Baltimore, Md. : 1950) Dec, 2008 | Pubmed ID: 19050292
CD40, autophagy and Toxoplasma gondii.
Memorias do Instituto Oswaldo Cruz Mar, 2009 | Pubmed ID: 19430652
CD40 and the immune response to parasitic infections.
Seminars in immunology Oct, 2009 | Pubmed ID: 19616968
Identification of primary retinal cells and ex vivo detection of proinflammatory molecules using flow cytometry.
Molecular vision Jul, 2009 | Pubmed ID: 19626134
Autophagy as an antimicrobial strategy.
Expert review of anti-infective therapy Aug, 2009 | Pubmed ID: 19681702
Autophagy in immunity against Toxoplasma gondii.
Current topics in microbiology and immunology , 2009 | Pubmed ID: 19802569
HIV-1 inhibits autophagy in bystander macrophage/monocytic cells through Src-Akt and STAT3.
PloS one Jul, 2010 | Pubmed ID: 20661303
Photoreceptor cells constitutively express functional TLR4.
Journal of neuroimmunology Jan, 2011 | Pubmed ID: 20801528
The CD40-autophagy pathway is needed for host protection despite IFN-Γ-dependent immunity and CD40 induces autophagy via control of P21 levels.
PloS one Dec, 2010 | Pubmed ID: 21217818
Chemokine (C-C motif) receptor 5 -2459 genotype in patients receiving highly active antiretroviral therapy: race-specific influence on virologic success.
The Journal of infectious diseases Jul, 2011 | Pubmed ID: 21673041
Review of the series "Disease of the year 2011: toxoplasmosis" pathophysiology of toxoplasmosis.
Ocular immunology and inflammation Oct, 2011 | Pubmed ID: 21970661
CD40 and tumour necrosis factor-α co-operate to up-regulate inducuble nitric oxide synthase expression in macrophages.
Immunology Feb, 2012 | Pubmed ID: 22044243
Guidelines for the use and interpretation of assays for monitoring autophagy.
Autophagy Apr, 2012 | Pubmed ID: 22966490
CD40 induces anti-Toxoplasma gondii activity in nonhematopoietic cells dependent on autophagy proteins.
Infection and immunity Jun, 2013 | Pubmed ID: 23509150
The protein kinase double-stranded RNA-dependent (PKR) enhances protection against disease cause by a non-viral pathogen.
PLoS pathogens , 2013 | Pubmed ID: 23990781
Modulation of retinal Müller cells by complement receptor C5aR.
Investigative ophthalmology & visual science Dec, 2013 | Pubmed ID: 24265019
Toxoplasma gondii-induced activation of EGFR prevents autophagy protein-mediated killing of the parasite.
PLoS pathogens , 2013 | Pubmed ID: 24367261
CD40 promotes the development of early diabetic retinopathy in mice.
Diabetologia Oct, 2014 | Pubmed ID: 25015056
Blockade of CD40-TRAF2,3 or CD40-TRAF6 is sufficient to inhibit pro-inflammatory responses in non-haematopoietic cells.
Immunology Jan, 2015 | Pubmed ID: 25051892
Proinflammatory responses induced by CD40 in retinal endothelial and Müller cells are inhibited by blocking CD40-Traf2,3 or CD40-Traf6 signaling.
Investigative ophthalmology & visual science Dec, 2014 | Pubmed ID: 25477319
Atg5 but not Atg7 in dendritic cells enhances IL-2 and IFN-γ production by Toxoplasma gondii-reactive CD4+ T cells.
Microbes and infection Apr, 2015 | Pubmed ID: 25578385
Di-retinoid-pyridinium-ethanolamine (A2E) Accumulation and the Maintenance of the Visual Cycle Are Independent of Atg7-mediated Autophagy in the Retinal Pigmented Epithelium.
The Journal of biological chemistry Nov, 2015 | Pubmed ID: 26468292
CD40-TRAF Signaling Upregulates CX3CL1 and TNF-α in Human Aortic Endothelial Cells but Not in Retinal Endothelial Cells.
PloS one , 2015 | Pubmed ID: 26710229
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Autophagy Jan, 2016 | Pubmed ID: 26799652
Identification of Signaling Pathways by Which CD40 Stimulates Autophagy and Antimicrobial Activity against Toxoplasma gondii in Macrophages.
Infection and immunity Sep, 2016 | Pubmed ID: 27354443
CD40 in Retinal Müller Cells Induces P2X7-Dependent Cytokine Expression in Macrophages/Microglia in Diabetic Mice and Development of Early Experimental Diabetic Retinopathy.
Diabetes Feb, 2017 | Pubmed ID: 27474370
Ligation of CD40 in Human Müller Cells Induces P2X7 Receptor-Dependent Death of Retinal Endothelial Cells.
Investigative ophthalmology & visual science Nov, 2016 | Pubmed ID: 27893093
Loss of CD40 attenuates experimental diabetes-induced retinal inflammation but does not protect mice from electroretinogram defects.
Visual neuroscience Jan, 2017 | Pubmed ID: 28965505
Toxoplasma gondii induces FAK-Src-STAT3 signaling during infection of host cells that prevents parasite targeting by autophagy.
PLoS pathogens Oct, 2017 | Pubmed ID: 29036202
Epidermal growth factor receptor promotes cerebral and retinal invasion by Toxoplasma gondii.
Scientific reports Jan, 2019 | Pubmed ID: 30679495
CD40 in Endothelial Cells Restricts Neural Tissue Invasion by Toxoplasma gondii.
Infection and immunity Aug, 2019 | Pubmed ID: 31109947
Interplay Between , Autophagy, and Autophagy Proteins.
Frontiers in cellular and infection microbiology , 2019 | Pubmed ID: 31119109
Toxoplasma gondii induces prolonged host epidermal growth factor receptor signalling to prevent parasite elimination by autophagy: Perspectives for in vivo control of the parasite.
Cellular microbiology Oct, 2019 | Pubmed ID: 31290228
CD40, a Novel Inducer of Purinergic Signaling: Implications to the Pathogenesis of Experimental Diabetic Retinopathy.
Vision (Basel, Switzerland) Aug, 2017 | Pubmed ID: 31740645
The CD40-ATP-P2X Receptor Pathway: Cell to Cell Cross-Talk to Promote Inflammation and Programmed Cell Death of Endothelial Cells.
Frontiers in immunology , 2019 | Pubmed ID: 31921199
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition).
Autophagy Feb, 2021 | Pubmed ID: 33634751
A cell-penetrating CD40-TRAF2,3 blocking peptide diminishes inflammation and neuronal loss after ischemia/reperfusion.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology Mar, 2021 | Pubmed ID: 33675257
Recent Advances in the Roles of Autophagy and Autophagy Proteins in Host Cells During Infection and Potential Therapeutic Implications.
Frontiers in cell and developmental biology , 2021 | Pubmed ID: 34179003
CD40 Expressed in Endothelial Cells Promotes Upregulation of ICAM-1 But Not Pro-Inflammatory Cytokines, NOS2 and P2X7 in the Diabetic Retina.
Investigative ophthalmology & visual science Sep, 2021 | Pubmed ID: 34546322
Disruption of retinal inflammation and the development of diabetic retinopathy in mice by a CD40-derived peptide or mutation of CD40 in Müller cells.
Diabetologia Dec, 2022 | Pubmed ID: 35920844
CD40 Upregulation in the Retina of Patients With Diabetic Retinopathy: Association With TRAF2/TRAF6 Upregulation and Inflammatory Molecule Expression.
Investigative ophthalmology & visual science Jun, 2023 | Pubmed ID: 37294707
Animal Models for Toxoplasma gondii Infection.
Current protocols Sep, 2023 | Pubmed ID: 37695167
Advanced Glycation End Products Upregulate CD40 in Human Retinal Endothelial and Müller Cells: Relevance to Diabetic Retinopathy.
Cells Feb, 2024 | Pubmed ID: 38474393
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