Dominique Debanne

What are the mechanisms for analogue and digital signalling in the brain?

Modulation of spike-evoked synaptic transmission: The role of presynaptic calcium and potassium channels.

Homeostatic regulation of h-conductance controls intrinsic excitability and stabilizes the threshold for synaptic modification in CA1 neurons.

Presynaptic hyperpolarization induces a fast analogue modulation of spike-evoked transmission mediated by axonal sodium channels.

The role of axonal Kv1 channels in CA3 pyramidal cell excitability.

How do electrical synapses regulate their strength?

LGI1 tunes intrinsic excitability by regulating the density of axonal Kv1 channels.

Plasticity of intrinsic excitability during LTD is mediated by bidirectional changes in h-channel activity.

Somatic modulation of ectopic action potential initiation in distal axons.

Pre- and postsynaptic effects of LGI1 autoantibodies in a murine model of limbic encephalitis.

Synaptic plasticity rules with physiological calcium levels.

Neural excitability increases with axonal resistance between soma and axon initial segment.

Calcium and Spike Timing-Dependent Plasticity.

Homeostatic regulation of axonal Kv1.1 channels accounts for both synaptic and intrinsic modifications in the hippocampal CA3 circuit.

Patient-derived antibodies reveal the subcellular distribution and heterogeneous interactome of LGI1.

Theta patterns of stimulation induce synaptic and intrinsic potentiation in O-LM interneurons.

A fast Markovian method for modeling channel noise in neurons.

Rescue of Normal Excitability in LGI1-Deficient Epileptic Neurons.

Enhanced Release Probability without Changes in Synaptic Delay during Analogue-Digital Facilitation.

Lipids shape brain function through ion channel and receptor modulations: physiological mechanisms and clinical perspectives.

cAMP reduces action potential amplitude and conduction velocity over long axonal distance.